USHROOM farming is the practice of growing and cultivating various species of mushrooms for food, medicinal, or industrial purposes. It involves creating the ideal environment and conditions for the mushrooms to grow and thrive, such as providing a substrate (a nutrient-rich material on which mushrooms grow), controlling temperature and humidity, and ensuring proper ventilation and lighting.Several innovative applications of mushrooms can be noticed in their farming and cultivation. These applications mainly focus on the medicinal and prebiotic attributes, besides their role in producing food and energy. This review is an attempt to highlight the cultivation of mushrooms and their requirements under different kinds of farming. These farming types may include mushroom-worm system, mushroom-bee farming, smart mushroom farming, forest-mushrooms farming, urban mushroom farming, and mushroom-livestock farming. In this study the condition of cultivation of several mushroom species and their edibility is included. Edible/medicinal mushrooms are well-known for their high content of many beneficial bioactive ingredients for human health such as antioxidants, ergosterols, lectins, phenolics/polyphenolics, polysaccharides, and terpenoids. These bioactives of mushrooms have the potential capability to treat and/or prevent several chronic diseases. The medicinal and prebiotic attributes of mushrooms still need more investigation, and this topic of "mushrooms in medicine" still has several open questions are needed to be answered in the future.