Mushroom polysaccharides from Ganoderma lucidum and Poria cocos reveal prebiotic functions

Khan, Imran; Huang, Guoxin; Li, Xiaoang; Leong, Waikit; Xia, Wenrui; Hsiao, W.L. Wendy

doi:10.1016/j.jff.2017.12.046

Cited by 115 publications

(56 citation statements)

References 79 publications

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“…In another study, normal C57BL/6 mice were intragastrically administered with Poria cocos polysaccharide for 15 consecutive days, followed by 16S rRNA gene sequencing of their feces (Khan, Huang, Li, Leong, Xia & Hsiao, 2018). Poria cocos polysaccharide significantly promoted the growth of Akkermansia muciniphila, a beneficial bacterium that enhances host immunity (de Vos, 2017), whereas the abundances of pro-inflammatory bacteria, including Alistipes massiliensis, Robinsoniella peoriensis and…”

Section: Regulation Of Population Balance Of Gut Microbiotamentioning

confidence: 99%

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Cao

et al. 2020

Carbohydrate Polymers

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Highlights: COVID-19 has become a Public Health Emergency of International Concern (PHEIC) and a worldwide pandemic  The Lung Cleansing and Detoxifying Decoction has shown definite therapeutic effects on COVID-19 patients  Bioactive polysaccharides in the decoction appear to involve immunomodulatory activity, antiinflammatory activity, anti-oxidative activity and regulation of gut microbiota balance  Producing COVID-19 vaccines with polysaccharides as the adjuvants is an innovative strategy Abstract J o u r n a l P r e -p r o o f 2The new coronavirus pneumonia, named COVID-19 by the World Health Organization, has become a pandemic. It is highly pathogenic and reproduces quickly. There are currently no specific drugs to prevent the reproduction and spread of COVID-19. Some traditional Chinese medicines, especially the Lung Cleansing and Detoxifying Decoction (Qing Fei Pai Du Tang), have shown therapeutic effects on mild and ordinary COVID-19 patients. Polysaccharides are important ingredients in this decoction. This review summarizes the potential pharmacological activities of polysaccharides isolated by hot water extraction from Lung Cleansing and Detoxifying Decoction, which is consistent with its production method, to provide the theoretical basis for ongoing research on its application.

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Section: Regulation Of Population Balance Of Gut Microbiotamentioning

confidence: 99%

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Cao

et al. 2020

Carbohydrate Polymers

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“…Polysaccharides from Pleurotus eryngii have the ability to improve gut dysbiosis by altering the concentration of SCFAs and composition of gut microbiota (Ma et al, 2017). Ganoderma lucidum polysaccharides can alleviate intestinal disorders and reduce obesity-related metabolic disorders (Chang et al, 2015;Khan et al, 2018).…”

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confidence: 99%

Characteristic of polysaccharides from Flammulina velutipes in vitro digestion under salivary, simulated gastric and small intestinal conditions and fermentation by human gut microbiota

Xie

et al. 2019

Int J of Food Sci Tech

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Summary In this study, in vitro digestion and fermentation of Flammulina velutipes ‐derived polysaccharides (FVP) were investigated. It was found that FVP mainly consisted of 48.45% glucose, 15.40% mannose, 14.60% xylose, 11.80% fucose and 9.90% galactose. The ‐human saliva, simulated gastric and small intestinal juices conditions did not break down the FVP. Based on in vitro fermentation tests, FVP modulated the composition of gut microbiota by elevating the amounts of Bifidobacteriaceae and Bacteroidaceae and reducing the numbers of genera Lachnospiraceae and Enterococcaceae. Meanwhile, FVP affected the synthesis of short‐chain fatty acids derived from gut microbiota.

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“…It also has reported that G. lucidum can produce a lot of chemicals like Ganoderma lucidum Polysaccharide, Ganodenic acid etc., having the ability of anti-tumor, anti-aging and detoxification [1][2][3] . Recent studies have found that G. lucidum polysaccharides produce anti-inflammatory, anti-obesity and anti-diabetes effects by modulating gut microbiota composition in mice 54,55 . These may help explain soil and microbial differences after Ling Zhi cultivation in some degree.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma lucidum cultivation affect microbial community structure of soil, wood segments and tree roots

Ren

Zhang

et al. 2020

Sci Rep

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The popular medicinal mushroom Ganoderma lucidum (Fr.) Karst. [Ling Zhi] has been widely used for the general promotion of health and longevity in Asian countries. Continuous cultivation may affect soil microbe and soil properties. However, the effect of G. lucidum cultivation on related wood segments, soil and tree roots microbial communities and soil properties is remain unknown. In our study, the microbial communities of soils, wood segments, and tree roots before and after G. lucidum cultivation were investigated by Illumina Miseq sequencing of both ITS and 16S rDNA, and taxonomic composition of eukaryotic and prokaryotic microorganisms were observed. Indices of microbial richness, diversity and evenness significantly differed between before and after G. lucidum cultivation. Each of the investigated sampling type harbored a distinctive microbial community and differed remarkably before and after G. lucidum cultivation. Ascomycota and Basidiomycota (fungi), Proteobacteria and Actinobacteria (bacteria) showed significant differences after Ling Zhi cultivation. The soil property values also changed after cultivation. The redundancy analysis (RDA) showed that both the fungal and bacterial community structure significantly correlated with soil humus, pH, nitrogen, carbon and trace elements (Fe, Zn, Mn, Cu) contents. The results indicated that G. lucidum cultivation may have significant differed the associated microbial community structures and soil properties. The study will provide useful information for G. lucidum cultivation and under-forest economic development.

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Mushroom polysaccharides from Ganoderma lucidum and Poria cocos reveal prebiotic functions

Cited by 115 publications

References 79 publications

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

Characteristic of polysaccharides from Flammulina velutipes in vitro digestion under salivary, simulated gastric and small intestinal conditions and fermentation by human gut microbiota

Ganoderma lucidum cultivation affect microbial community structure of soil, wood segments and tree roots

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