Mussel-inspired degradable antibacterial polydopamine/silica nanoparticle for rapid hemostasis

Liu, Chunyu; Yao, Weihe; Tian, Meng; Wei, Junnan; Song, Qiling; Qiao, Weihong

doi:10.1016/j.biomaterials.2018.06.037

Cited by 203 publications

(159 citation statements)

References 49 publications

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“…Therefore, nanosilica forms new composite materials with graphene, polydopamine, selenium, zinc oxide, silver, and other materials that have antibacterial effects 78‐80 . These materials have achieved satisfactory results in areas such as food preservation and clothing that needs to inhibit bacteria 81‐83 . In the development of medical materials for local hemostasis, a porous network structure that contains hydroxyl groups and amino groups was prepared by coating polydopamine on the surface of nanosilica particles.…”

Section: Antibacterial Application Of Silica Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial applications and safety issues of silica‐based materials: A review

Tian

Liu

2020

Int J Applied Ceramic Tech

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As the problem of bacterial contamination continues to grow in its significance, researchers have reported many antibacterial materials that are based on inorganic compounds. Of these, materials that are based on silica and its derivatives have been widely used in engineering, medicine, and food. This paper reviews the advantages, safety issues, and applications of silica and its derivatives, as reported in recent years. The information provided highlights the preparation, application, and antimicrobial efficiency of materials that are based on silica and have different structure/size. We outline the possible antimicrobial mechanisms of silica‐based materials and the potential challenges that researchers may face. With a focus on increasing concerns regarding bacterial contamination in the food and medical industries, we have also proposed corresponding antibacterial material preparation strategies.

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Section: Antibacterial Application Of Silica Materialsmentioning

confidence: 99%

“…Compared to commercial Celox in vitro hemostasis (for which clotting time is shortened by 150 seconds), it is important that new materials inhibit E coli for up to 208 hours. The study laid a solid foundation for practical applications of pharmaceutical materials 81 …”

Section: Antibacterial Application Of Silica Materialsmentioning

confidence: 99%

Antibacterial applications and safety issues of silica‐based materials: A review

Tian

Liu

2020

Int J Applied Ceramic Tech

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“…The material has phenolic hydroxyl groups and amino groups. Studies have shown that this material has obvious hemostatic effect, low exotherm, and good antibacterial effect …”

Section: Hemostasis At Nanoscalementioning

confidence: 99%

Recent Advances in Hemostasis at the Nanoscale

Wang

Liu

Sui

et al. 2019

Adv Healthcare Materials

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Rapid and effective hemostatic materials have received wide attention not only in the battlefield but also in hospitals and clinics. Traditional hemostasis relies on materials with little designability which has many limitations. Nanohemostasis has been proposed since the use of peptides in hemostasis. Nanomaterials exhibit excellent adhesion, versatility, and designability compared to traditional materials, laying a good foundation for future hemostatic materials. This review first summarizes current hemostatic methods and materials, and then introduces several cutting‐edge designs and applications of nanohemostatic materials such as polypeptide assembly, electrospinning of cyanoacrylate, and nanochitosan. Particularly, their advantages and working mechanisms are introduced. Finally, the challenges and prospects of nanohemostasis are discussed.

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“…Given these criteria, hemostats based on fluid or micro-/nanoparticles have shown potential applicability for the therapy of perforating and irregular hemorrhage, [10][11][12] as their transformable feature facilitates easy access to bleeding aisles and contact with hidden hemorrhagic sites. [13] Gelatin, [14] chitosan, [15] starch, [16] silica, [17] and kaolin [10] have been widely evaluated as raw or base materials for hemostats due to their rapid blood absorption and/or coagulation cascade capabilities. [18][19][20] Nevertheless, these materials require external force to travel against the blood flow to ultimately reach the deep bleeding sites, leading to coagulation at the superficial wound layers only.…”

Section: Introductionmentioning

confidence: 99%

Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

et al. 2020

Adv Funct Materials

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Achieving rapid and safe control of perforating and irregular hemorrhage, defined as bleeding wounds with irregular external and internal wound shape, located deep within complex and covert hemorrhage sites, is vital to decrease the risk of mortality during prehospital treatments and surgical procedures. However, current hemostatic materials do not control hemorrhage effectively as their ability to access the bleeding source and coagulate blood is limited. Here, a biphasic Janus self-propelled hemostatic particle (MSS@CaCO 3) is prepared via uniaxial growth of flower-like calcium carbonate crystal (CaCO 3) on negatively-modified-microporous starch (MSS). The as-synthesized hemostatic particle (MSS@CaCO 3 T) is loaded with thrombin and powered by the internal component CaCO 3, with the collaborative use of protonated tranexamic acid. These particles are capable of traveling against the blood flow allowing them to access deep bleeding sites, inducing synergistic blood coagulation effects to effectively halt hemorrhaging. The self-propelling Janus hemostatic particle is sufficiently available in the deep bleeding sites of liver and femoral artery hemorrhage models, wherein the hemorrhage is rapidly controlled in ≈50 s and ≈3 min, respectively. To the authors' knowledge, this is the first attempt of controlling hemorrhage using Janus hemostatic particles with a self-propelling property.

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Mussel-inspired degradable antibacterial polydopamine/silica nanoparticle for rapid hemostasis

Cited by 203 publications

References 49 publications

Antibacterial applications and safety issues of silica‐based materials: A review

Antibacterial applications and safety issues of silica‐based materials: A review

Recent Advances in Hemostasis at the Nanoscale

Self‐Propelling Janus Particles for Hemostasis in Perforating and Irregular Wounds with Massive Hemorrhage

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