Mutagenicity testing of the pyrethroid insecticide cypermethrin in Drosophila

Batiste-Alentorn, M.; Xamena, N.; Velázquez, Antonia; Creus, A.; Marcos, Ricard

doi:10.1093/mutage/1.5.343

Cited by 19 publications

(5 citation statements)

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“…Cypermethrin crosses placental barrier and produces harmful effects in embryo even at very low concentrations. Exposure to cypermethrin reduces DNA content and may lead to mutation, especially germline mutation leading to teratological deformities [32, 38, 39]. Cypermethrin produces mutagenicity and genotoxicity by interacting with DNA metabolic processes, sister chromatid exchange and free radical generation machinery [40, 41].…”

Section: Dna Damagementioning

confidence: 99%

A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration

Singh

Tiwari²,

Prakash³

et al. 2012

144

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Cypermethrin, a class II pyrethroid pesticide, is used to control insects in the household and agricultural fields. Despite beneficial roles, its uncontrolled and repetitive applications lead to unintended effects in non-target organisms. Cypermethrin crosses the blood-brain barrier and induces neurotoxicity and motor deficits. Cypermethrin prolongs the opening of sodium channel, a major site of its action, leading to hyper-excitation of the central nervous system. In addition to sodium channel, cypermethrin modulates chloride, voltage-gated calcium and potassium channels, alters the activity of glutamate and acetylcholine receptors and adenosine triphosphatases and induces DNA damage and oxidative stress in the neuronal cells. Cypermethrin also modulates the level of neurotransmitters, including gamma-aminobutyric acid and dopamine. It is one of the most commonly used pesticides in neurotoxicology research not only because of its variable responses depending upon the doses, time and routes of exposure and strain, age, gender and species of animals used across multiple studies but also owing to its ability to induce the nigrostriatal dopaminergic neurodegeneration. This article describes the effect of acute, chronic, developmental and adulthood exposures to cypermethrin in experimental animals. The article sheds light on cypermethrin-induced changes in the central nervous system, including its contribution in the onset of specific features, which are associated with the nigrostriatal dopaminergic neurodegeneration. Resemblances and dissimilarities of cypermethrin-induced nigrostriatal dopaminergic neurodegeneration with sporadic and chemicals-induced disease models along with its advantages and pitfalls are also discussed.

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Section: Dna Damagementioning

confidence: 99%

A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration

Singh

Tiwari²,

Prakash³

et al. 2012

144

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“…Surrallés et al (1990) also described a strong inhibition of cell cycle progression and an increased frequency of micronuclei induced by fenvalerate in cultured human lymphocytes, indicating its clastogenic and/or aneugenic activity. On the other hand, reports suggesting no genotoxic effects of fenvalerate have also been published (Hadnagy et al, 1999;Batiste-Alentorn et al, 1986;Herrera and Laborda, 1988).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic effects on human spermatozoa among pesticide factory workers exposed to fenvalerate

Xia

Bian

et al. 2004

Toxicology

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“…Cypermethrin has been reported to induce gene mutations in male germ cells of Drosophila (Batiste-Alentorn et al, 1986) and genotoxicity and sperm abnormality in mice (Bhunya and Pati, 1988). Surrallés et al (1995b), studying whole blood and isolated human lymphocyte cultures, reported that cypermethrin has a weak genotoxic activity in vitro.…”

Section: Introductionmentioning

confidence: 99%

Induction of sister chromatid exchanges by cypermethrin and carbosulfan in bone marrow cells of mice in vivo

Giri

Giri²,

Sharma³

et al. 2003

Mutagenesis

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The public health effects of pesticides cannot be denied. However, the undesired effects of chemical pesticides have been recognized as a serious public health concern during the past decades. The present study describes the genotoxic effects of two pesticides, namely cypermethrin and carbosulfan, in a murine test system in vivo. The test parameter used was analysis of sister chromatid exchanges (SCE) in bone marrow cells. Both cypermethrin (5, 10 and 20 mg/kg) and carbosulfan (1.25, 2.5 and 5 mg/kg) induced significant increases in the frequency of SCEs (P < 0.001). However, no significant dose-response correlation could be found for either of the pesticides. Carbosulfan induced a cell cycle delay, as evidenced by an increase in average generation time accompanied by accumulation of cells in the first division cycle, but cypermethrin did not induce any such response. The present study indicates that carbosulfan has a higher potential to cause genetic alterations than cypermethrin in mice and may also pose a mutagenic risk to human beings.

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Mutagenicity testing of the pyrethroid insecticide cypermethrin in Drosophila

Cited by 19 publications

References 0 publications

A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration

A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration

Genotoxic effects on human spermatozoa among pesticide factory workers exposed to fenvalerate

Induction of sister chromatid exchanges by cypermethrin and carbosulfan in bone marrow cells of mice in vivo

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