Myasthenia gravis with diffuse alopecia areata and pemphigus foliaceus

Izumi, Yasumori; Kinoshita, Ikuo; Kita, Yoshiko; Toriyama, Fumi; Taniguchi, Hideki; Motomura, Masakatsu; Yoshimura, Tsuyoshi

doi:10.1007/s00415-002-0821-2

Cited by 7 publications

(4 citation statements)

References 6 publications

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“…Although pemphigus foliaceus and myasthenia gravis are both relatively common antibody-mediated autoimmune disorders, they have only rarely been noted to occur together. In some reported cases, patients have had pemphigus foliaceus in addition to both myasthenia gravis and a thymoma [10,11,12,13,14]. However, like several other cases reported, our patient did not have a thymoma [15,16,17,18].…”

Section: Discussionsupporting

confidence: 57%

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Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis

Liebman

Lieberman²,

Burris³

2016

Dermatology Online Journal

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Pemphigus foliaceus (PF) is a sporadic autoimmune blistering disease of unknown etiology. The production of immunoglobulin G4 antibodies against desmoglein-1 is responsible for the clinical manifestation of PF. We present a case of a woman with a recent diagnosis of myasthenia gravis (MG), who was also recently treated with radiation therapy for breast cancer. The clinical exam, supported by biopsy and direct immunofluorescence, were consistent with PF. We present this case to increase the awareness of the potential exacerbation or induction of PF with radiation, and of the association of PF and myasthenia gravis. Only five prior cases of radiation-exacerbated or radiation-induced PF have been reported in the literature to date. Furthermore, the co-existence of the autoimmune entities of myasthenia gravis and PF has been reported in the literature in only 9 cases and was also noted in this patient.

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Section: Discussionsupporting

confidence: 57%

“…To the best of our knowledge, only 9 cases of pemphigus foliaceus coexisting with myasthenia gravis have been reported in the literature [7,8,10,11,12,13,14,15,16]. Although pemphigus foliaceus and myasthenia gravis are both relatively common antibody-mediated autoimmune disorders, they have only rarely been noted to occur together.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus foliaceus exacerbated by radiation, in association with myasthenia gravis

Liebman

Lieberman²,

Burris³

2016

Dermatology Online Journal

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“…A total of 29 cases with alopecia and myasthenia gravis including our case have been reported (Table 1). 5–21 Twenty‐two cases (75.9%) were Asian population, indicating a possibility of the race different conditions to cause the comorbidity.…”

Section: Discussionmentioning

confidence: 99%

“…4 A total of 29 cases with alopecia and myasthenia gravis including our case have been reported (Table 1). [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Twenty-two cases (75.9%)…”

Section: Ta B L Ementioning

confidence: 99%

A case of myasthenia gravis following alopecia areata

Sasaki,

Sawada

2023

J Cutaneous Imm & Allergy

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We present a case of myasthenia gravis that occurred after alopecia areata and evaluate the literature on the comorbidity of alopecia and myasthenia gravis. A 41‐year‐old male noticed hair loss on his scalp 4 months ago, and his hair loss progressed with drooping of both upper eyelids and diplopia. Physical and laboratory examination identified the comorbidity of myasthenia gravis and alopecia areata. Prednisolone 10 mg/day and tacrolimus 3 mg/day were administered for 7 days following hospitalization, which served to improve diplopia and ptosis. Following methylprednisolone therapy, hair loss in alopecia areata improved without the enlargement of bald areas. Based on the literature review, a total of 29 cases with alopecia and myasthenia gravis including our case have been reported. Among them, seven cases of myasthenia gravis developed after alopecia. The average time for the onset of myasthenia gravis after alopecia was 16.6 months. Four cases showed other autoimmune disease comorbidity, such as vitiligo, lichen planus, cutaneous lupus erythematosus, and pemphigus foliaceus, suggesting the involvement of Th1‐significant immunological states in these patients.

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