Mycobacterial biofilms: Understanding the genetic factors playing significant role in pathogenesis, resistance and diagnosis

Patel, Ritu Raj; Arun, Pandey Priya; Singh, Sudhir Kumar; Singh, Meenakshi

doi:10.1016/j.lfs.2024.122778

Life Sciences

2024

DOI: 10.1016/j.lfs.2024.122778

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Mycobacterial biofilms: Understanding the genetic factors playing significant role in pathogenesis, resistance and diagnosis

Ritu Raj Patel,

Pandey Priya Arun,

Sudhir Kumar Singh

et al.

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2024

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Cited by 2 publications

References 140 publications

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Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M. Smegmatis

Sarangi,

Das,

Pahuja

et al. 2024

Arch Microbiol

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Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M. Smegmatis

Sarangi,

Das,

Pahuja

et al. 2024

Arch Microbiol

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Mycobacterial Biofilm: Mechanisms, Clinical Problems, and Treatments

Liu,

Hu,

Wang

et al. 2024

IJMS

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Tuberculosis (TB) remains a threat to human health worldwide. Mycobacterium tuberculosis (Mtb) and other nontuberculous mycobacteria (NTM) can form biofilms, and in vitro and animal experiments have shown that biofilms cause serious drug resistance and mycobacterial persistence. Deeper investigations into the mechanisms of mycobacterial biofilm formation and, consequently, the exploration of appropriate antibiofilm treatments to improve the efficiency of current anti-TB drugs will be useful for curing TB. In this review, the genes and molecules that have been recently reported to be involved in mycobacterial biofilm development, such as ABC transporter, Pks1, PpiB, GroEL1, MprB, (p)ppGpp, poly(P), and c-di-GMP, are summarized. Biofilm-induced clinical problems, including biofilm-related infections and enhanced virulence, as well as their possible mechanisms, are also discussed in detail. Moreover, we also illustrate newly synthesized anti-TB agents that target mycobacterial biofilm, as well as some assistant methods with high efficiency in reducing biofilms in hosts, such as the use of nanoparticles.

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Mycobacterial biofilms: Understanding the genetic factors playing significant role in pathogenesis, resistance and diagnosis

Cited by 2 publications

References 140 publications

Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M. Smegmatis

Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M. Smegmatis

Mycobacterial Biofilm: Mechanisms, Clinical Problems, and Treatments

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