Myocardial adaptability in young and older-aged sea-level habitants sojourning at Mt Kilimanjaro: are cardiac compensatory limits reached in older trekkers?

Stewart, Glenn M.; Wheatley‐Guy, Courtney M.; Morris, Norman; Coffman, Kirsten E.; Štěpánek, Jan; Carlson, Alex R.; Issa, Amine; Schmidt, Michael A.; Johnson, Bruce D.

doi:10.1007/s00421-020-04319-3

Cited by 3 publications

(34 citation statements)

References 41 publications

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“…Similarly, no changes in RV-FAC were revealed in 9 studies out of 15 (Dedobbeleer et al, 2015;Hilty et al, 2016;Maufrais et al, 2017;Berger et al, 2018;De Boeck et al, 2018;Stembridge et al, 2019;Sareban et al, 2020;Ewalts et al, 2021;Lichtblau et al, 2021). In contrast, in other 6 studies, decreased RV-FAC upon acute high-altitude induction suggested reduced RV systolic function (Stewart et al, 2020;Tian et al, 2020;Yang et al, 2020a,b;He et al, 2021;Yuan et al, 2021). Maintained RV-MPI over the course of high-altitude stay was reported in 3 studies out of 9 (Berger et al, 2018;Sareban et al, 2020;Gaur et al, 2021).…”

Section: Right Ventricular Systolic Functionmentioning

confidence: 94%

“…Frontiers in Physiology | www.frontiersin.org (Stewart et al, 2020) 3 days 3,100 (Stewart et al, 2020) 3 days 3,00…”

Section: Right Ventricular Systolic Functionmentioning

confidence: 99%

“…In addition, three studies reported inconsistent changes in TAPSE values over the course of high-altitude acclimatization (Hilty et al, 2019;Sareban et al, 2020;Gaur et al, 2021). Another frequently evaluated RV systolic function parameter RV-S ′ was reported in 17 studies (Huez et al, 2009;Page et al, 2013;Boos et al, 2014;Stembridge et al, 2014;Dedobbeleer et al, 2015;Maufrais et al, 2017Maufrais et al, , 2019Berger et al, 2018;De Boeck et al, 2018;Sareban et al, 2020;Stewart et al, 2020;Tian et al, 2020;Yang et al, 2020a,b;Gaur et al, 2021;He et al, 2021;Yuan et al, 2021). In 11 studies, RV-S ′ values were maintained up to 21 days of high-altitude sojourn suggesting preserved RV systolic function (Huez et al, 2009;Page et al, 2013;Boos et al, 2014;Stembridge et al, 2014;Dedobbeleer et al, 2015;Maufrais et al, 2017;Tian et al, 2020;Yang et al, 2020a,b;Gaur et al, 2021;He et al, 2021).…”

Section: Right Ventricular Systolic Functionmentioning

confidence: 99%

“…In some studies, RV-EDA and RV-ESA values were indexed to body surface area (Tian et al, 2020;He et al, 2021). In 8 studies out of 13, RV-EDA values remained unchanged upon high-altitude exposure (Stembridge et al, 2014(Stembridge et al, , 2019Hilty et al, 2016;Maufrais et al, 2017;Sareban et al, 2020;Yang et al, 2020b;Ewalts et al, 2021;Yuan et al, 2021), while they were increased in 2 (De Boeck et al, 2018;Stewart et al, 2020) and decreased in 3 studies (Tian et al, 2020;Yang et al, 2020a;He et al, 2021). Similarly, high-altitude induction did not alter RV-ESA values in 10 studies (Stembridge et al, 2014(Stembridge et al, , 2019Maufrais et al, 2017;Sareban et al, 2020;Tian et al, 2020;Yang et al, 2020a,b;Ewalts et al, 2021;He et al, 2021;Yuan et al, 2021) and was associated with increased RV-ESA values in 2 studies (De Boeck et al, 2018;Stewart et al, 2020).…”

Section: Right Ventricular Morphologymentioning

confidence: 99%

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Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review

et al. 2022

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Background: Acute hypoxia exposure is associated with an elevation of pulmonary artery pressure (PAP), resulting in an increased hemodynamic load on the right ventricle (RV). In addition, hypoxia may exert direct effects on the RV. However, the RV responses to such challenges are not fully characterized. The aim of this systematic review was to describe the effects of acute hypoxia on the RV in healthy lowland adults.Methods: We systematically reviewed PubMed and Web of Science and article references from 2005 until May 2021 for prospective studies evaluating echocardiographic RV function and morphology in healthy lowland adults at sea level and upon exposure to simulated altitude or high-altitude.Results: We included 37 studies in this systematic review, 12 of which used simulated altitude and 25 were conducted in high-altitude field conditions. Eligible studies reported at least one of the RV variables, which were all based on transthoracic echocardiography assessing RV systolic and diastolic function and RV morphology. The design of these studies significantly differed in terms of mode of ascent to high-altitude, altitude level, duration of high-altitude stay, and timing of measurements. In the majority of the studies, echocardiographic examinations were performed within the first 10 days of high-altitude induction. Studies also differed widely by selectively reporting only a part of multiple RV parameters. Despite consistent increase in PAP documented in all studies, reports on the changes of RV function and morphology greatly differed between studies.Conclusion: This systematic review revealed that the study reports on the effects of acute hypoxia on the RV are controversial and inconclusive. This may be the result of significantly different study designs, non-compliance with international guidelines on RV function assessment and limited statistical power due to small sample sizes. Moreover, the potential impact of other factors such as gender, age, ethnicity, physical activity, mode of ascent and environmental factors such as temperature and humidity on RV responses to hypoxia remained unexplored. Thus, this comprehensive overview will promote reproducible research with improved study designs and methods for the future large-scale prospective studies, which eventually may provide important insights into the RV response to acute hypoxia exposure.

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Section: Right Ventricular Systolic Functionmentioning

confidence: 94%

“…Frontiers in Physiology | www.frontiersin.org (Stewart et al, 2020) 3 days 3,100 (Stewart et al, 2020) 3 days 3,00…”

Section: Right Ventricular Systolic Functionmentioning

confidence: 99%

Section: Right Ventricular Systolic Functionmentioning

confidence: 99%

Section: Right Ventricular Morphologymentioning

confidence: 99%

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Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review

et al. 2022

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“…Масса сердца животных групп О-1 и О-2 возросла к моменту окончания эксперимента на 62,4 и 38,4 % соответственно (p<0,05), что свидетельствует в пользу выраженных адаптивных перестроек организма, связанных со снабжением систем организма кислородом, что соотносится с литературными данными [7,8]. Но в условиях жесткой модели адаптации эти изменения более значительны.…”

Section: оригинальные исследованияunclassified

Bone mineral density of female rats in the process of adaptation to simulated durative intermittent hypobaric hypoxia

Belyaev¹,

Rzhepakovsky²,

Piskov³

et al. 2020

Medical news of the North Caucasus

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Bone mineral densiTY of female raTs in The process of adapTaTion To simulaTed duraTiVe inTermiTTenT hYpoBaric hYpoXia Belyaev n. g., rzhepakovsky i. V., piskov s. i., plyuiko V. V. north-caucasus federal university, stavropol, russian federation Представлена оценка минеральной плотности бедренной кости методом рентгеновской компьютерной микротомографии и показателей адаптивных процессов самок крыс при моделировании хронической прерывистой гипобарической гипоксии. Увеличение массы сердца и надпочечников, повышение количества эритроцитов и гемоглобина явились маркерами компенсаторных процессов. Полученные результаты указывают на то, что длительное прерывистое воздействие гипобарической гипоксии как в условиях жесткой адаптации, так и с постепенным наращиванием стресс-фактора служит фактором, способствующим остеопоротическим изменениям в костной ткани. Ключевые слова: гипоксическая гипоксия, гипобарическая хроническая гипоксия, минеральная плотность костной ткани, самки крыс, адаптация The estimation of femoral mineral density by Х-ray computer microtomography and indicators of adaptive processes in female rats in the simulation of chronic intermittent hypobaric hypoxia is presented. An increase in heart and adrenal mass, an increase in the number of red blood cells and hemoglobin were markers of compensatory processes. The obtained results indicate that long-term intermittent exposure to hypobaric hypoxia, both in conditions of severe adaptation, and with a gradual build-up of the stress factor, can lead to osteoporotic changes in the bone tissue.

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Hypoxia and the Aging Cardiovascular System

Raberin¹,

Burtscher²,

Burtscher³

et al. 2023

Aging and disease

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Older individuals represent a growing population, in industrialized countries, particularly those with cardiovascular diseases, which remain the leading cause of death in western societies. Aging constitutes one of the largest risks for cardiovascular diseases. On the other hand, oxygen consumption is the foundation of cardiorespiratory fitness, which in turn is linearly related to mortality, quality of life and numerous morbidities. Therefore, hypoxia is a stressor that induces beneficial or harmful adaptations, depending on the dose. While severe hypoxia can exert detrimental effects, such as high-altitude illnesses, moderate and controlled oxygen exposure can potentially be used therapeutically. It can improve numerous pathological conditions, including vascular abnormalities, and potentially slows down the progression of various age-related disorders. Hypoxia can exert beneficial effects on inflammation, oxidative stress, mitochondrial functions, and cell survival, which are all increased with age and have been discussed as main promotors of aging. This narrative review discusses specificities of the aging cardiovascular system in hypoxia. It draws upon an extensive literature search on the effects of hypoxia/altitude interventions (acute, prolonged, or intermittent exposure) on the cardiovascular system in older individuals (over 50 years old). Special attention is directed toward the use of hypoxia exposure to improve cardiovascular health in older individuals.

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Myocardial adaptability in young and older-aged sea-level habitants sojourning at Mt Kilimanjaro: are cardiac compensatory limits reached in older trekkers?

Cited by 3 publications

References 41 publications

Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review

Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review

Bone mineral density of female rats in the process of adaptation to simulated durative intermittent hypobaric hypoxia

Hypoxia and the Aging Cardiovascular System

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