Myogene Larynxtumoren

Leiomyosarcoma of the larynx

“…The extent of excision depends on the anatomic site and degree of differentiation. In poorly to moderately differentiated LMS, Kleinsasser and Glanz [15] recommend radical surgery involving laryngectomy and neck dissection. Since well-differentiated LMS grows very slowly, surgery that retains laryngeal function is preferred.…”

“…If sonography of cervical lymph nodes is negative, formal neck dissection is not necessary [20]. LMS of the larynx, like that in other sites, does not respond to radiotherapy or chemotherapy, although such treatment modalities can be applied as palliative measures in inoperable cases [15,20].…”

“…Several authors have emphasized the difficulty of distinguishing LMS from other spindle cell tumors, especially rhabdomyosarcomas and fibrosarcomas [2,15]. Precise histologic characterization of an LMS requires both histochemical and immunocytochemical analyses.…”

“…Since mitotic activity can vary widely within a single lesion, a malignant tumor can appear benign in some areas. Since this can lead to false diagnoses, especially if only small tissue specimens are examined, tumor material must be subjected to histologic examination in serial sections [15].…”

Das primäre pleomorphe Rhabdomyosarkom des Kehlkopfs

“…Bis 1976 lag die Zahl der beschriebenen Fälle von RMS des Kehlkopfs bei nur 24 Fällen [2]. Dreizehn zusätzliche Einzelfallbeschreibungen folgten bis zum heutigen Tage [3][4][5][6][7][8][9][10], Bei der Mehrzahl der gut dokumentierten Fälle handelte es sich um die embryonale Form des RMS (etwa 70%). Neben 2 Fällen eines alveolären RMS [4,6] wurden insgesamt nur 7 Fälle des pleomorphen Typs dokumentiert [3,4,[11][12][13][14] …”