Myricetin 3′-rhamnoside-3-galactoside from Buchanania lanzan (anacardiaceae)

Nasim, Kh. Takrimullah; Arya, Rekha; Babu, Vikas; Ilyas, M.

doi:10.1016/0031-9422(92)83334-u

Cited by 19 publications

(4 citation statements)

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“…[ 12 ] Myricetin 3’-rhamnoside-3-galactoside, celidoniol, vomicine, and pinitol are reported. [ 13 ] Immunostimulant properties for B. lanzan with a capacity to enhanced macrophage migration index, hemagglutinating antibody titers, plaque-forming cell counts as parameters of humoral immunity was observed and efficacy against cyclophosphamide induced genotoxicity and oxidative stress in mice has been reported. [ 14 ] Earlier studies report on the use of methanolic extract of leaves,[ 12 ] kernel,[ 15 ] and roots[ 16 ] with anti-inflammatory, antioxidant and analgesic properties using in vivo rat paw edema model is available.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of reactive oxygen/nitrogen species with suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by bark extract of Buchanania lanzan

Sekhar

Sampathkumara²,

Niranjana

et al. 2015

Phcog Mag

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Background:Oxidative stress is one of the most critical factors implicated in disease conditions. Buchanania lanzan Spr. (Anacardiaceae) bark powder preparation has been reported for treating an inflammatory condition in the Ayurvedic Pharmacopoeia of India.Objective:In the present study, we investigate the effect of the bark methanol extract (BLM) on reactive oxygen/nitrogen species (ROS/RNS), the expression of protein and mRNA of inducible nitric oxide synthase (iNOS) in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) and sodium nitroprusside (SNP) to provide scientific validation of the above said medicinal property.Materials and Methods:The capacity to quench ROS and RNS was evaluated by 5-(and-6) chloromethyl-20,70-dichlorodihydrofluorescein diacetate acetyl ester fluorescence and nitrite estimations in LPS/SNP-stimulated macrophages respectively. The protein and transcript expression of iNOS was evaluated through Western Blot and reverse transcription-polymerase chain reaction (RT-PCR) analysis respectively.Results:Macrophages pretreated with BLM (>100 μg/mL) for 24 h, stimulated with LPS for the last 18 h of experimental duration recorded a significantly (P < 0.05) reduced levels of ROS (3.45-fold) against LPS-stimulated conditions (5.7-fold). SNP-stimulation resulted in increased NO accumulation (17-fold) which was neutralized by BLM at >100 μg/ml (1.6-fold) credited to a reduced protein and mRNA expression of iNOS as recorded by Western blots and RT-PCR results respectively. The reversed-phase liquid chromatography-diode array detection analysis identified the presence of 4-hydroxybenzoic acid, quercetin and p-coumaric acid (Rt values 5.444, 5.569 and 9.580 respectively).Conclusions:The potential of BLM inhibiting ROS/RNS production validates the medical use of bark, could find beneficial application under conditions of immune stimulation and/or bacterial infection.

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Section: Introductionmentioning

confidence: 99%

Attenuation of reactive oxygen/nitrogen species with suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by bark extract of Buchanania lanzan

Sekhar

Sampathkumara²,

Niranjana

et al. 2015

Phcog Mag

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“…This finding is in accordance with the structure proposed for the ion m/ z 609, which has 2 rhamnosyl groups bonded to the myricetin aglycone. The literature reports a structure for myricetin-3′- O -rhamnose-3- O -galactoside [46]; therefore, a similar structure carrying two rhamnosyl groups in positions 3 and 3′ of the aglycone was proposed: myricetin-3- O -rhamnose-3′- O -rhamnoside. No reports on the identification of compounds II, III, VI, VII, IX, XII, XIV, XV, XVI, or XVII in the Inga species have been found.…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves

Martins

Morais

Martins

et al. 2019

The Scientific World Journal

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The species Inga laurina is native to the Brazilian Cerrado. There are no studies about the chemical composition and biological activities of extracts of this endangered species. The ethanolic extract and its successive fractions are rich in phenolic compounds and presented good antifungal activities. HPLC/MS-MS/MS and H1/C13 analysis led to the identification of seventeen compounds, most of which are gallic acid derivatives, myricetin and quercetin glycosides. The ethyl acetate fraction (EAF) contained high levels of total phenolics, expressed in milligrams of gallic acid equivalents per gram of extract (475.3 ± 1.9 mg GAE gextract-1) and flavonoids expressed in milligrams of quercetin equivalents per gram of extract (359.3 ± 10.6 mg QE gextract-1). This fraction was active against fungi of the Candida genus. The EAF showed MIC value 11.7 μg mL−1 against C. glabrata and a selectivity index of 1.6 against Vero cells. The flavonol glycoside myricetin-3-O-rhamnoside was isolated for the first time from the Inga laurina. These results make I. laurina a promising plant as a source of pharmaceutical and biological active antifungal compounds.

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“…Of late, researchers are focusing their attention on various forest plants including Chironji. The leaves are reported to contain tannins, triterpenoids, saponins, flavonoids, kaempferol-7-o'glucosides, quercetin-3rahmnoglucoside, quercetin, gallic acid, kaemferol, and reducing sugars, including a new glycoside, and myricetin-3'-rhmnoside-3-galactoside (Nasim et al, 1992;Mehta et al,2010). The bark contains tannins, alkaloids, and saponins.…”

Section: Phytochemical Profilementioning

confidence: 99%

Chironji (Buchanania lanzan) Wonder Tree: Nutritional and Therapeutic Values

Neeraj¹,

Bisht²,

Purwar³

2020

Int.J.Curr.Microbiol.App.Sci

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Chironji (Buchanania lanzan Spreng.) is a member of the family Anacardiaceae and it is originated in the Indian sub-continent, is an excellent multipurpose tree species. Traditional indigenous knowledge reveals the immense value of almost all parts of the plant i.e. roots, leaves, fruits, seeds and gum for various medicinal uses. Chironji (Buchanania lanzan) is an important non-wood tree species found in deciduous forests throughout the greater part of India. It is a multipurpose tree and very important plant for rural and tribal economy. It is used as a fuel, fodder, alternative host for Kusmi lac insect, and also used in cosmetic items and soaps. Seeds/ kernel are nutritional, palatable and used as a substitute of almonds in confectionery. It is widely used by Indian tribes for treating various diseases. Three major chemical constituents of potent medicinal value, namely celidoniol, vomicine, epinitol have been characterized from an organic extract of leaves. Such extracts mainly exhibit antidiabetic, anti hyperlipidemic, antioxidant, antiinflammatory, wound healing, antidiarrheal, antivenom activity including a host of other curative properties. Very recently, unique biomaterials and biofilms are being extracted from seeds, which promise to become a major contributor in pharmaceutical industry. At present, it is growing under forest condition as an under exploited fruit and gives monitory reward to tribal community of the country. The tree is natural wild growth in the tropical deciduous forests of Northern, Western and Central India, mostly in the States of Chhattisgarh, Jharkhand, Madhya Pradesh and in Varanasi and Mirzapur districts and Bundelkhand region of Uttar Pradesh. Chironji is a vulnerable medicinal plant, is included in the Red Data Book published by International Union for Conservation of Nature and Natural Resources. In this background, there is compelling need for developing a suitable technology facilitating easy multiplication, regeneration and conservation of the species, simultaneously imparting and disseminating proper knowledge and education to the tribal population. K e y w o r d sDeciduous forests tribal community knowledge and education

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Myricetin 3′-rhamnoside-3-galactoside from Buchanania lanzan (anacardiaceae)

Cited by 19 publications

References 4 publications

Attenuation of reactive oxygen/nitrogen species with suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by bark extract of Buchanania lanzan

Attenuation of reactive oxygen/nitrogen species with suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by bark extract of Buchanania lanzan

Chemical Composition, Antifungal, and Cytotoxicity Activities of Inga laurina (Sw.) Willd Leaves

Chironji (Buchanania lanzan) Wonder Tree: Nutritional and Therapeutic Values

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