Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Domitrović, Robert; Rashed, Khaled; Cvijanović, Olga; Vladimir‐Knežević, Sanda; Škoda, Marko; Višnić, Alenka

doi:10.1016/j.cbi.2015.01.030

Cited by 180 publications

(123 citation statements)

References 42 publications

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“…However, few studies have reported the impact of hyperglycemia on Akt signaling in H9c2 cells. Consistent with previous reports [16], our results showed that myricitrin increased HO-1 and NQO-1 expression, activated Akt, as a classical signaling pathway, has been reported to be tightly related to cell apoptosis, the latter of which has been confirmed to regulate Nrf2 activation [18,21]. However, few studies have reported the impact of hyperglycemia on Akt signaling in H9c2 cells.…”

Section: Discussionsupporting

confidence: 92%

“…Collectively, myricitrin exerted its anti-apoptotic effect by eliminating ROS production and restoring MMP. Akt, as a classical signaling pathway, has been reported to be tightly related to cell apoptosis, the latter of which has been confirmed to regulate Nrf2 activation [21,18]. However, few studies have reported the impact of hyperglycemia on Akt signaling in H9c2 cells.…”

Section: Discussionmentioning

confidence: 99%

“…Our laboratory previously demonstrated that myricitrin can attenuate endothelial cell apoptosis via PI3K/Akt signaling activation [17]. In addition, myricitrin reportedly possesses effective antioxidant, anti-inflammatory and antifibrotic activity [18]. Nevertheless, the potential role of myricitrin in diabetic cardiomyopathy remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes

et al. 2016

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Hyperglycemia, as well as diabetes mellitus, has been shown to trigger cardiac cell apoptosis. We have previously demonstrated that myricitrin prevents endothelial cell apoptosis. However, whether myricitrin can attenuate H9c2 cell apoptosis remains unknown. In this study, we established an experiment model in H9c2 cells exposed to high glucose. We tested the hypothesis that myricitrin may inhibit high glucose (HG)-induced cardiac cell apoptosis as determined by TUNEL staining. Furthermore, myricitrin promoted antioxidative enzyme production, suppressed high glucose-induced reactive oxygen species (ROS) production and decreased mitochondrial membrane potential (MMP) in H9c2 cells. This agent significantly inhibited apoptotic protein expression, activated Akt and facilitated the transcription of NF-E2-related factor 2 (Nrf2)-mediated protein (heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1) expression as determined by Western blotting. Significantly, an Akt inhibitor (LY294002) or HO-1 inhibitor (ZnPP) not only inhibited myricitrin-induced HO-1/NQO-1 upregulation but also alleviated its anti-apoptotic effects. In summary, these observations demonstrate that myricitrin activates Nrf2-mediated anti-oxidant signaling and attenuates H9c2 cell apoptosis induced by high glucose via activation of Akt signaling.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes

et al. 2016

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“…Pro-inflammatory cytokines initiate an inflammatory cascade and promote the migration of neutrophils into the alveoli. In this present study, myricetin obviously decreased the production of these cytokines both in vitro and in vivo (Domitrovic et al, 2015;Jung et al, 2017;Jung et al, 2008;Walker et al, 2000).…”

Section: Discussionsupporting

confidence: 60%

“…Myricetin (3,3′,4′,5,5′, is an abundant flavonoid compound extracted from natural ingredients such as berries, herbs and vegetables (Salvamani et al, 2014). It contributes to the prevention and/or delay of various pathological processes including cancer, neurodegenerative diseases, and inflammatory disorders (Choi et al, 2017;Domitrovic et al, 2015). However, little is concerned about its preventive response on LPS-induced lung injury.…”

Section: Introductionmentioning

confidence: 99%

Myricetin Attenuates LPS-induced Inflammation in RAW 264.7 Macrophages and Mouse Models

Hou

et al. 2018

Preprint

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Validation of stability‐indicating LC method, degradation study, and impact on antioxidant and antifungal activities of Eugenia uniflora leaves extract

Santos

Lima

Machado

et al. 2023

Biomedical Chromatography

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The aim of this study is to demonstrate the stability‐indicating capacity of an analytical method for Eugenia uniflora, enhance understanding of the stability of myricitrin, and assess the effect of degradation of spray‐dried extract (SDE) on antioxidant and antifungal activities. Validation of the stability‐indicating method was carried out through a forced degradation study of SDE and standard myricitrin. The antioxidant and antifungal activities of SDE were evaluated both before and after degradation. The quantification method described was found to be both accurate and precise in measuring myricitrin levels in SDE from E. uniflora, with excellent selectivity that confirmed its stability‐indicating capability. The forced degradation study revealed that the marker myricitrin is sensitive to hydrolysis, but generally stable under other stress conditions. By contrast, the standard myricitrin displayed greater susceptibility to degradation under forced degradation conditions. Analysis of the antioxidant activity of SDE before and after degradation showed a negative impact in this activity due to degradation, while no significant effect was observed on antifungal activity. The method described can be a valuable tool in the quality control of E. uniflora, and the findings can assist in determining the optimal conditions and storage of products derived from this species.

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Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Cited by 180 publications

References 42 publications

Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes

Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes

Myricetin Attenuates LPS-induced Inflammation in RAW 264.7 Macrophages and Mouse Models

Validation of stability‐indicating LC method, degradation study, and impact on antioxidant and antifungal activities of Eugenia uniflora leaves extract

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