n-3 versus n-6 polyunsaturated fatty acids in critical illness

Tashiro, Tsuguhiko; Yamamori, Hideo; Takagi, Kazuya; Hayashi, Naganori; Furukawa, Katsunori; Nakajima, Nobuyuki

doi:10.1016/s0899-9007(98)00048-3

Cited by 61 publications

(35 citation statements)

References 13 publications

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“…Higher 18:33 intake significantly reduced total fatty acid accumulation in NSW pig livers, mostly by lowering 6 PUFA, (Table 4), an effect consistent with reports showing that raised intake of 20:53 inhibits fatty acid accumulation in the liver of rats infused with lipopolysaccharide and Escherichia coli (23,24).…”

Section: Discussionsupporting

confidence: 88%

“…The 40% higher total fatty acid content of the liver in NSW pigs on the control (low 18:33) diet is consistent with other animal models of infection (23,24). Higher 18:33 intake significantly reduced total fatty acid accumulation in NSW pig livers, mostly by lowering 6 PUFA, (Table 4), an effect consistent with reports showing that raised intake of 20:53 inhibits fatty acid accumulation in the liver of rats infused with lipopolysaccharide and Escherichia coli (23,24).…”

Section: Discussionsupporting

confidence: 87%

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Whole-body β-oxidation of 18:2ω6 and 18:3ω3 in the pig varies markedly with weaning strategy and dietary 18:3ω3

Bazinet

McMillan

Seebaransingh

et al. 2003

Journal of Lipid Research

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

Whole-body β-oxidation of 18:2ω6 and 18:3ω3 in the pig varies markedly with weaning strategy and dietary 18:3ω3

Bazinet

McMillan

Seebaransingh

et al. 2003

Journal of Lipid Research

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“…This observation might be linked to better survival of fish oil-fed animals when exposed to endotoxin (for references, see Calder, 2001). Fish oil-containing parenteral nutrition decreased serum TNF-a, IL-6 and IL-8 concentrations in burned rats compared with n-6 PUFA-rich parenteral nutrition Tashiro et al 1998). Likewise, surgical patients infused with a fish oil-rich emulsion showed lower TNF-a concentrations in the bloodstream at some time points compared with patients receiving a control infusion (Wachtler et al 1997).…”

Section: Inflammation In Atherosclerosismentioning

confidence: 99%

Fatty acids and the immune system: from basic science to clinical applications

Yaqoob

2004

Proc. Nutr. Soc.

119

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Over the last 25 years, the effects of fatty acids on the immune system have been characterized usingin vitro, animal and human studies. Advances in fatty acid biochemistry and molecular techniques have recently suggested new mechanisms by which fatty acids could potentially modify immune responses, including modification of the organization of cellular lipids and interaction with nuclear receptors. Possibilities for the clinical applications ofn-3 PUFA are now developing. The present review focuses on the hypothesis that the anti-inflammatory properties ofn-3 PUFA in the arterial wall may contribute to the protective effects ofn-3 PUFA in CVD, as suggested by epidemiological and secondary prevention studies. Studies are just beginning to show that dietaryn-3 PUFA can be incorporated into plaque lipid in human subjects, where they may influence the morphology and stability of the atherosclerotic lesion.

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“…It is well known that EPA has an anti-inflammatory effect decreasing proinflammatory cytokines (Tashiro et al 1998, Zhao et al 2004) and both cyclooxygenase-2 activity and expression (Hurst et al 2009). Furthermore, EPA is able to decrease joint inflammation in rheumatoid arthritis patients (James & Cleland 1997, Simopoulos 2002) and in arthritic rats (Leslie et al 1985, Volker et al 2000, Castillero et al 2009b.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of the n-3 polyunsaturated fatty acid eicosapentaenoic and fenofibrate on the inhibitory effect of arthritis on IGF1

Castillero

López-Menduiña²,

Martín³

et al. 2011

Journal of Endocrinology

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Adjuvant-induced arthritis is a chronic inflammatory illness that induces muscle wasting and decreases circulating IGF1. Eicosapentaenoic acid (EPA) and fenofibrate, a peroxisome proliferator-activated receptors a agonist, have anti-inflammatory actions and ameliorate muscle wasting in arthritic rats. The aim of this work was to elucidate whether EPA and fenofibrate administration are able to prevent the effect of arthritis on the IGF1-IGFBP system. On day 4 after adjuvant injection control, arthritic rats were gavaged with EPA (1 g/kg) or fenofibrate (300 mg/kg) until day 15 when all rats were killed. Arthritis decreased body weight gain, serum IGF1, and liver Igf1 mRNA, whereas it increased gastrocnemius Igfbp3 mRNA. EPA, but not fenofibrate, administration prevented arthritis-induced decrease in serum IGF1 and liver Igf1 mRNA. In the rats treated with EPA arthritis increased Igfbp5 mRNA in the gastrocnemius. Fenofibrate treatment decreased IGF1 and Igf1 mRNA in the liver and gastrocnemius. In arthritic rats, fenofibrate increased body weight gain and decreased gastrocnemius Igfbp3 and Igfbp5 mRNA. These data suggest that the mechanisms through which EPA and fenofibrate act on the IGF1 system and ameliorate muscle wasting in arthritic rats are different. EPA administration increased circulating levels of IGF1, whereas fenofibrate decreased the Igfbp3 and Igfbp5 in the gastrocnemius muscle.

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n-3 versus n-6 polyunsaturated fatty acids in critical illness

Cited by 61 publications

References 13 publications

Whole-body β-oxidation of 18:2ω6 and 18:3ω3 in the pig varies markedly with weaning strategy and dietary 18:3ω3

Whole-body β-oxidation of 18:2ω6 and 18:3ω3 in the pig varies markedly with weaning strategy and dietary 18:3ω3

Fatty acids and the immune system: from basic science to clinical applications

Comparison of the effects of the n-3 polyunsaturated fatty acid eicosapentaenoic and fenofibrate on the inhibitory effect of arthritis on IGF1

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