N-Acetyl Cysteine in Combination with Vitamin C Enhances the Antioxidant Status of a Lung Carcinoma Cell Line in Vitro.

Vanisree, Arambakkam Janardhanam; Ramamurthy, Narayan; Shyamaladevi, Chennam Srinivasulu

doi:10.3164/jcbn.26.1

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…52) In the present study, the elevated activity of 5Ј-ND was observed in cancer bearing animals and upon administration of quercetin to lung cancer bearing animals the activity of 5Ј-ND was brought down to near normal values indicating its antitumour and/or antiproliferative effect on lung cancer.…”

Section: Discussionmentioning

confidence: 73%

The Effects of Quercetin on Antioxidant Status and Tumor Markers in the Lung and Serum of Mice Treated with Benzo(a)pyrene

Kamaraj

Vinodhkumar

Anandakumar

et al. 2007

Biological & Pharmaceutical Bulletin

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Chemoprevention has emerged as a very effective preventive measure against carcinogenesis. Several bioactive compounds present in fruits and vegetables have revealed their cancer curative potential on benzo(a)pyrene (B(a)P) induced carcinogenesis. In the present study, the efficacy of quercetin on the level of lipid peroxides, activities of antioxidant enzymes and tumor marker enzymes in B(a)P induced experimental lung carcinogenesis in Swiss albino mice was assessed. In lung cancer bearing animals there was an increase in lung weight, lipid peroxidation and marker enzymes such as aryl hydrocarbon hydroxylase, gamma glutamyl transpeptidase, 5-nucleotidase, lactate dehydrogenase and adenosine deaminase with subsequent decrease in body weight and antioxidant enzymes-superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, reduced glutathione, vitamin E and vitamin C. Quercetin supplementation (25 mg/kg body weight) attenuated all these alterations, which indicates the anticancer effect that was further confirmed by histopathological analysis. Overall, the above data shows that the anticancer effect of quercetin is more pronounced when used as an chemopreventive agent rather than as a chemotherapeutic agent against B(a)P induced lung carcinogenesis.

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Section: Discussionmentioning

confidence: 73%

The Effects of Quercetin on Antioxidant Status and Tumor Markers in the Lung and Serum of Mice Treated with Benzo(a)pyrene

Kamaraj

Vinodhkumar

Anandakumar

et al. 2007

Biological & Pharmaceutical Bulletin

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show abstract

“…Unpredictably, 100 mg/kg PCA pretreatment could not reverse the elevated γ-GT caused by DMN. This might be due to the induction of γ-GT synthesis in the presence of chemical carcinogens (Vanisree and Shyamala, 1999;Lee et al, 2004).…”

Section: Evaluation Of Phase 1 Drug Metabolizing Enzymesmentioning

confidence: 99%

Protocatechuic acid modulates hepatic oxidative stress and inflammation linked to DMN exposure in rat

Asejeje,

Etim,

Asejeje

et al. 2023

NJPS

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Dimethyl nitrosamine (DMN), a potent hepatotoxin, exerts carcinogenic effects and induces hepatic necrosis in experimental animals via CYP2E1 metabolic activation, and generation of reactive oxygen species (ROS). Protocatechuic acid (PCA), a plant-based simple phenolic compound and potent antioxidant, has been shown to affect the development of neoplasia in the rat liver and inhibit the initiation or progression phases of most cancers. In this study, the modulatory effects of PCA on DMN-induced hepatotoxicity, oxidative stress, inflammation, and selected phase I xenobiotic metabolizing enzymes were investigated in male Wistar rats. This study assessed biomarkers of hepatic injury (alanine transaminase, aspartate aminotransferase, alkaline phosphatase, and gamma- glutamyl transferase); oxidative stress (hydrogen peroxide concentration, lipid peroxidation, and reduced glutathione levels); measured activities of antioxidant enzymes (catalase, sodium dismutase, glutathione peroxidase, glutathione S-transferase); and inflammation (Tumor necrosis factor (TNF)-α, interleukin-1-Beta (IL-1β) and iNOS). The results of our investigation demonstrated that pretreatment with PCA at 50 and 100 mg/kg body weight p.o. reduced DMN (20 mg/kg bw) i.p. mediated hepatic injury, oxidative stress, and inflammation in a dose-dependent manner. In addition, the activities of phase I metabolizing enzymes were significantly induced except for aminopyrine-N-demethylase in the DMN-treated rats when compared with the DMN alone control group. This induction was also reversed by pre-treatment with PCA. The result of this study suggests that PCA is hepatoprotective against DMN-induced hepatic damage by its ability to suppress oxidative stress, inflammation, and modulate the activities of the selected phase I drug metabolizing enzymes. Thus, PCA may prove useful in combating DMN-induced hepatic damage

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The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells — In vitro

Vanisree

Shyamaladevi

2006

Life Sciences

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N-Acetyl Cysteine in Combination with Vitamin C Enhances the Antioxidant Status of a Lung Carcinoma Cell Line in Vitro.

Cited by 3 publications

References 27 publications

The Effects of Quercetin on Antioxidant Status and Tumor Markers in the Lung and Serum of Mice Treated with Benzo(a)pyrene

The Effects of Quercetin on Antioxidant Status and Tumor Markers in the Lung and Serum of Mice Treated with Benzo(a)pyrene

Protocatechuic acid modulates hepatic oxidative stress and inflammation linked to DMN exposure in rat

The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells — In vitro

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