N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs

Skander, Myriem; Retailleau, Pascal; Bourrié, Bernard; Schio, Laurent; Mailliet, Patrick; Marinetti, Angéla

doi:10.1021/jm901693m

Cited by 164 publications

(109 citation statements)

References 54 publications

(52 reference statements)

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“…近些年来, 有关金络合物超分子抗癌作用的研究主要集中在金的唑类氮杂环卡宾(NHC)方面 [70,71] . 金属氮杂环卡宾能够抑制硫氧还蛋白还原酶(Thioredoxin reductase, TrxR)和其它蛋白质的活性导致癌细胞死亡 [72] , 因此, 构建基于氮杂环卡宾的金属超分子对抗癌药物的研发有重要意义.…”

Section: 金类唑超分子作为抗癌药物unclassified

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Cheng¹,

Wang²,

Addla³

et al. 2016

Chin. J. Org. Chem.

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Noncovalent bond forces-based supramolecular chemistry grows quite rapidly and has been revealed to have extensively potential applications and huge development values in chemistry, physics, materials and information science, medicine and so on. Azole compounds such as imidazoles, thiazoles, oxazoles, pyrazoles, triazoles, tetrazoles and carbazoles containing special nitrogen aromatic heterocyclic structure, can exert non-covalent forces to form supramolecular complexes with inorganic and/or organic compounds and exhibit broad biological activity. In recent years, heterocyclic azole-based supramolecular complexes have been expeditiously expanding in the field of medicine, and have become a quite hot topic. Combined with our work and referring to other literature in recent 5 years, this paper systematically reviews the researches and applications of azole-based supermolecules as medicinal agents including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, anti-inflammatory drugs and other ones. Finally, the perspectives of the future development of azole-based supermolecules as medicinal agents are also presented.

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Section: 金类唑超分子作为抗癌药物unclassified

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Cheng¹,

Wang²,

Addla³

et al. 2016

Chin. J. Org. Chem.

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“…The primary goal of MCRs research is to synthesize heterocyclic compounds, which make up the majority of pharmaceuticals, agrochemicals, natural products, and drug-like molecules [4,5]. In a true sense, these reactions are environmentally friendly processes by reducing the number of steps, energy consumption, and waste output [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…CH 3 ),5.93 (s, 1H, CH),6.74 (d, J = 8 Hz, 1H, ArH), 6.8 (t, J = 7.2 Hz, 1H, ArH), 7.02 (t, J = 7.6 Hz, 1H, ArH), 7.24 (d, J = 7.2 Hz, 1H, ArH), 7.33 (t, J = 7.6 Hz 1H, ArH), 7.41 (d, J = 7.6 Hz, 2H, ArH), 7.72 (t, J = 8 Hz, 2H, ArH),8.29 (d, J = 8.4 Hz, 1H, ArH) ppm;13 C NMR (100 MHz, CDCl 3 ): d 15.00, 20.64, 27.95, 30.91, 37.29, 63.87, 112.12, 114.7, 118.28, 120.44, 124.22, 126.72, 127.78, 128.41, 131.40, 132.04, 132.99, 147.88, 156.31, 165.96, 197.15 ppm; Anal. calcd.…”

mentioning

confidence: 99%

Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies

2014

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An efficient one-pot synthesis of xanthene and chromene derivatives by three-component reactions of aryl aldehydes, cyclic 1,3-diketones, and 2-naphthol/ 4-hydroxy coumarin catalyzed by ionic liquid (IL) [bmim] [PF 6 ] under microwave irradiation is described. The present scheme provides several advantages such as short reaction time, mild reaction conditions, good yields, convenient operation, and reuse of IL. In vitro antioxidant activity was evaluated for the synthesized compounds by DPPH method. Compounds 6a, 6h, 6c, 6b, 4k, and 4a showed the highest antioxidant potency.

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“…The well-known anticancer drug cisplatin has serious side effects, and its effectiveness is reduced by acquired drug resistance [5,6]. This provides the impetus to search for other metal-based drugs.…”

Section: Introductionmentioning

confidence: 99%

DNA-binding and photocleavage, cytotoxicity, apoptosis and antioxidant activity studies of ruthenium(II) complexes

Xie

Zhong

et al. 2012

Transition Met Chem

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Two ruthenium(II) polypyridyl complexes, namely [Ru(phen) 2 (DMDPPZ)](ClO 4 ) 2 1 (phen = 1,10-phenanthroline, DMDPPZ = 3,6-dimethyldipyrido[3,2-a: 2 0 ,3 0 -c]phenazine) and [Ru(dmp) 2 (DMDPPZ)](ClO 4 ) 2 2 (dmp = 2,9-dimethyl-1,10-phenanthroline), have been synthesized and characterized. The DNA-binding properties of the complexes were investigated by spectrophotometric methods, viscosity measurements, and photoactivated cleavage studies. The DNA-binding constants for complexes 1 and 2 have been determined as 8.78 (±0.94) 9 10 5 M -1 (s = 3.02) and 1.26 (±0.35) 9 10 5 M -1 (s = 1.69), respectively. The results suggest that these complexes bind to calf thymus DNA through intercalation. When irradiated at 365 nm, the complexes promote the photocleavage of pBR322 DNA, and complex 1 cleaves DNA more effectively than complex 2 under comparable experimental conditions. The cytotoxicities of complexes 1 and 2 have been evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method. Complex 2 shows higher anticancer potency than complex 1 against four tumor cell lines. The apoptosis-inducing activity was assessed by acridine orange/ethidium bromide staining assay, and the antioxidant activities of these complexes against hydroxyl radical were also explored.

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N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs

Cited by 164 publications

References 54 publications

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies

DNA-binding and photocleavage, cytotoxicity, apoptosis and antioxidant activity studies of ruthenium(II) complexes

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