N-Methylimidazolium anion-exchange stationary phase for high-performance liquid chromatography

Qiu, Hongdeng; Jiang, Shengxiang; Liu, Xia

doi:10.1016/j.chroma.2005.11.035

Cited by 203 publications

(97 citation statements)

References 33 publications

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“…Effective separation of anions using tartaric acid or o-phthalic acid as eluent was achieved while relative strong unwanted matrix effect was also observed. By immobilizing N-methylimidazolium ionic liquid onto silica gel, Liu et al prepared an anion exchanger for the separation of anions [8]. They demonstrated good separation of organic anions and inorganic anions and multimode retention mechanism were observed.…”

Section: Introductionmentioning

confidence: 99%

A polar-copolymerized method to prepare silica-based anion exchanger for ion chromatography

Zhang

Guo

et al. 2011

Talanta

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Section: Introductionmentioning

confidence: 99%

A polar-copolymerized method to prepare silica-based anion exchanger for ion chromatography

Zhang

Guo

et al. 2011

Talanta

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“…German) and it was activated by the following procedure [37,39]: 100.0 g silica was stirred with nitric acid/water (50:50, v/v) at room temperature for 2 h and refluxed for 8 h. Then the activated silica was filtered and washed thoroughly with distilled water and acetone. The aim of pretreatment is to enhance the content of silanol groups on the silica surface and to eliminate metal oxide and nitrogenous impurity.…”

Section: Preparation Of Ionic Liquid-based Silicamentioning

confidence: 99%

“…Some kinds of ionic liquid-based silica particles were synthesized and used as a HPLC stationary phase to separate some inorganic ions and familiar organic compounds [36][37][38]. However, there are relatively few reports on its application as a selective sorbent in the extraction of certain active components directly from natural plants.…”

Section: Introductionmentioning

confidence: 99%

Solid‐phase extraction of liquiritin and glycyrrhizic acid from licorice using ionic liquid‐based silica sorbent

Tian

Row

2009

J of Separation Science

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A new ionic liquid-based silica sorbent was developed by a process involving surface chemical modification of commercial silica using a synthesized ionic liquid. The obtained particles were successfully used as a special sorbent in a solid-phase extraction process to isolate liquiritin and glycyrrhizic acid from licorice. Different washing and elution solvents, such as water, methanol/water (v/v), and pure methanol were evaluated. Ionic liquid-based silica sorbent was compared with traditional C 18 sorbent and it exhibited higher selectivity. Quantitative analysis was carried out by using a C 18 column. Good linearities of two compounds were obtained from 5 Â 10 À4 to 0.2 mg/mL (r 2 40.99) with the relative standard deviations o1.0%. The target compounds in commercial herbal medicines containing licorice were determined, and the bound rates between the target compounds and protein were obtained by this sorbent.

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“…35 First, the silica was immersed in hydrochloric acid for 24 h and then washed with deionized water and dried under vacuum for 8 h at 120 ºC. The activated silica (5.0 g) was suspended in 60 mL of dry toluene and then an excess of 3-chloropropyltrimethoxysilane (5.0 g) was added, followed by adding 0.5 mL of hydrochloric acid as a catalyst.…”

Section: Synthesis Of the N-methylimidazolium-grafted Silica Stationamentioning

confidence: 99%

“…The preparation procedure of Mim-Sil was modified from the literature 35 for the ClPr-Sil synthesis step. We used hydrochloric acid as the catalyst instead of triethylamine because we found that it was much easier to purify the ClPr-Sil when acid was used as the catalyst.…”

Section: Preparation and Characterization Of Mim-silmentioning

confidence: 99%

Study on the Mixed-Mode HPLC Separation of Shuang-Huang-Lian and Xue‑Bi‑Jing Injections Based on an Ionic Liquid Column

Yang¹,

Zhang²,

Zhang³

et al. 2018

J. Braz. Chem. Soc.

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Both Shuang-Huang-Lian and Xue-Bi-Jing injections are clinically proven efficient and low cost medicines. However, the studies of their chromatographic separation are limited. In this study, a column based on ionic liquid stationary phase was applied for the first time for the analysis of these two injections. For Shuang-Huang-Lian injection, U-shaped plots of retention factors vs. mobile phase constitutions were obtained. This unique kind of separation behavior allowed a flexible adjustment of retention by tuning the mobile phase constituents. Then acids group was analyzed with hydrophilic chromatography mode, while glycosides group was analyzed with reversed phase chromatography mode. Similarly, constituents in Xue-Bi-Jing injection were analyzed with mixed mode high performance liquid chromatography (HPLC). Higher, medium and lower polarity groups were analyzed with hydrophilic interaction, reversed phase and normal phase liquid chromatography modes, respectively. Results from this work provided valuable information for the separation of complicated systems such as traditional Chinese medicine injections.Keywords: ionic liquid stationary phase, mixed-mode chromatography, Shuang-Huang-Lian injection, Xue-Bi-Jing injection IntroductionThe formulations of traditional Chinese medicines (TCMs) are becoming increasingly popular worldwide, mainly because of their high efficiency and low cost. However, TCM formulations are usually based on a whole plant and/or combination of several herbs, which contain more than dozens to hundreds of components. 1 Therefore, in order to ensure both the safety and efficacy of TCM formulations, it is necessary to establish simple and effective methods to determine as many constituents as possible.2,3 Liquid chromatography (LC) has been applied as a rapid and economic method for the determination of multi-component in TCMs. 4 Among the liquid chromatography analytical methods, high performance liquid chromatography (HPLC) is the most popular one, due to its easy operation, wide suitability and high accuracy for the qualitative and quantitative analysis of TCMs. [5][6][7] However, in practice, some factors, such as efficiency, selectivity and sensitivity have been found to affect the analysis of complicated systems with HPLC. 8Chromatographic stationary phase is the core of HPLC system. Therefore, the development of novel stationary phases with high separation efficiency and excellent selectivity has always been the focus point of improving the separating ability of HPLC. Accordingly, in this work novel ionic liquid (IL) bonded stationary phase has been studied. IL is a kind of novel material composed of ions and at the same time remains in liquid state at a temperature below 100 °C.9 ILs have demonstrated the versatility and tuneability in separation science. 10 Many types of ILs were immobilized on a support like silica or monolith as stationary phases for liquid chromatography. 11,12 Due to the designable character of the IL molecule, multi interactions between the IL stationary phas...

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N-Methylimidazolium anion-exchange stationary phase for high-performance liquid chromatography

Cited by 203 publications

References 33 publications

A polar-copolymerized method to prepare silica-based anion exchanger for ion chromatography

A polar-copolymerized method to prepare silica-based anion exchanger for ion chromatography

Solid‐phase extraction of liquiritin and glycyrrhizic acid from licorice using ionic liquid‐based silica sorbent

Study on the Mixed-Mode HPLC Separation of Shuang-Huang-Lian and Xue‑Bi‑Jing Injections Based on an Ionic Liquid Column

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