Nahrungsfolate — Eine aktuelle Übersicht Stabilität, Physiologische Bedeutung, Bioverfügbarkeit, analytische Bestimmungsmethoden, Einfluß der Lebensmittelbehandlung

Abstract

Because of the unequal and, in some instances, low stability of different folate vitamers against extreme conditions the analytical determination of folate and the estimation of folate losses in food processing and preparation cause considerable difficulties. HPLC allows determination of the native folate derivative patterns. As the bioavailability of folates is influenced by a variety of factors and different methods were employed for assessing bioavailability there is a considerable inconsistency in the results of these studies. Folates labeled with radioactive or stable isotopes provide new approaches to metabolic and bioavailability studies.

Effect of Type of Heat Treatment of Breastmilk on Folate Content and Pattern

“…37,38 H 4 folate is known to be less stable than 5-CH 3 -H 4 folate. In agreement with the literature, 3 losses during heat treatment in the present trial were mainly attributable to degradation of H 4 folate. Hence, the relative proportion of 5-CH 3 -H 4 folate increased.…”

“…The vitamers are susceptible to degradation by light, oxygen, or heat and can be split into compounds without any vitamin activity. [1][2][3] Progress in neonatal intensive care has led to improved survival of preterm infants. For infants born preterm, breastmilk, as compared with formula, has been shown to reduce the risk of necrotizing enterocolitis 4 and to be associated with higher IQ at school age.…”

Effect of Ionizing Radiation on Folates in Food

“…It is also noteworthy that the bioavailability of monoglutamates is much higher than that of polyglutamates (12). The tendency toward some conversion of polyglutamates to monoglutamates indicated by our results, most clearly seen in the case of Brussels sprouts (Fig.…”

“…Biological activity is attributed to a large number of compounds, of which 5,6,7,8-tetrahydrofolic acid (THF) and its 5-formyl and 5-methylderivatives are the principal ones. There are several other folic acid vitamers, and each of these can occur with one or more (up to eight) glutamate molecules attached by peptide bond to the basic structure (12). The folic acid derivatives can be separated by high performance liquid chromatography (HPLC) (13).…”

Solubility Determination of Active Pharmaceutical Ingredients Which Have Been Recently Added to the List of Essential Medicines in the Context of the Biopharmaceutics Classification System–Biowaiver

“…Degradation rates of folic acid and rifabutin at acidic pH values observed in this study are in accordance with results of degradation studies found in the literature. 22,[78][79][80][81] Succimer dissolved directly after immersion in the different buffers, but a large amount had sedimented after the 24-h incubation. Immediately after adding the media, hydrogen sulfide was detected organoleptically, especially with the more acidic media.…”