Naloxone Microinjected into the Arcuate Nucleus Has Differential Effects on Ventilation in Male and Female Rats

Schlenker, Evelyn H.; Martin, Doug; Lin, Xue; Egland, M.C.

doi:10.1016/s0031-9384(97)80330-7

Cited by 15 publications

(10 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study observed higher p-opioid receptor binding among women (Zubieta, Dannals, & Frost, 1999), suggesting that the observed increase in cortisol in the present study was a result of greater antagonism of the central opioid system stemming from increased naltrexone binding in women. These results add to an increasing body of literature on sex differences in opioid sensitivity and opioid-hormone interactions in humans and animals (e.g., Barbarino et al, 1987;Crowley, 1988;Fernandez et al, 1999;Klein, Popke, & Grunberg, 1998;Kreek, Schluger, Borg, Gunduz, & Ho, 1999;Schlenker, Martin, Lin, & Egland, 1997;Zubieta et al, 1999). Interestingly, there are no published reports on sex differences in the pharmacokinetics of naltrexone per se, and the naltrexone manufacturer, DuPont Pharma (Wilmington, DE), reports no indication of gender differences in the pharmacokinetics of naltrexone in company records (L. Lupo, personal communication, November 14,2000).…”

Section: Discussionsupporting

confidence: 55%

“…Although pharmacologically similar to naloxone, naltrexone is two to eight times more potent than naloxone (Blumberg & Dayton, 1973;Verebely & Mule, 1975), and naltrexone's actions last hours longer than do naloxone's actions (Martin, Jasinski, & Mansky, 1973). These results add to an increasing body of literature on sex differences in opioid sensitivity and opioid-hormone interactions in humans and animals (e.g., Barbarino et al, 1987;Crowley, 1988;Fernandez et al, 1999;Klein, Popke, & Grunberg, 1998;Kreek, Schluger, Borg, Gunduz, & Ho, 1999;Schlenker, Martin, Lin, & Egland, 1997;Zubieta et al, 1999). A recent study observed higher p-opioid receptor binding among women (Zubieta, Dannals, & Frost, 1999), suggesting that the observed increase in cortisol in the present study was a result of greater antagonism of the central opioid system stemming from increased naltrexone binding in women.…”

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

Sex Differences in Salivary Cortisol Levels Following Naltrexone Administration1

Klein

Jamner

Alberts

et al. 2000

J Appl Biobehavioral Res

View full text Add to dashboard Cite

Effects of endogenous opioid peptide blockade by naltrexone on salivary Cortisol levels were examined in healthy men (n= 8) and women (n= 6). Participants received naltrexone (100 mg) during one laboratory session and a placebo pill during another session. Drug order was counterbalanced across participants. Saliva samples were collected 24 hr after each pill was administered. Among women, salivary Cortisol levels significantly increased following naltrexone administration compared with a placebo pill. Naltrexone administration did not alter salivary Cortisol levels in men. Results suggest sex differences in neuroendocrine sensitivity to opioid blockade, a finding that may hold significance with regard to the treatment of alcohol addiction with naltrexone.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 65%

Sex Differences in Salivary Cortisol Levels Following Naltrexone Administration1

Klein

Jamner

Alberts

et al. 2000

J Appl Biobehavioral Res

View full text Add to dashboard Cite

show abstract

“…*Significantly different from morphine-treated females, P≤0.05, SNK test sant effects in male than in female rats. We are not aware of any previous studies indicating sex differences in respiratory depressant effects of morphine; however, endogenous opioids appear to modulate ventilation in a sexually dimorphic manner, with males being more sensitive than females to the hypoventilatory effects of naloxone microinjected into the arcuate nucleus of the hypothalamus (Schlenker et al 1997). Additionally, we have observed previously that morphine produces more sedation in males than in females responding in operant procedures (Stratmann and Craft 1997;Craft et al 1998), and on a locomotor activity assay (Boyer et al 1998).…”

Section: Figmentioning

confidence: 94%

Sex differences in development of morphine tolerance and dependence in the rat

Craft¹,

Stratmann²,

Bartok³

et al. 1999

Psychopharmacology

168

View full text Add to dashboard Cite

show abstract

“…With the use of Boyle's law, the pressure changes were calibrated with a glass syringe attached to the chamber by injection of a known volume of gas into the chamber. This barometric method to evaluate ventilation has been used previously in our laboratory (33,34). Ventilatory parameters included tidal volume, frequency of breathing, and minute ventilation.…”

Section: Animalsmentioning

confidence: 99%

Gender-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats

Schlenker

Tamura²,

Gerdes³

2003

Journal of Applied Physiology

View full text Add to dashboard Cite

der-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats. J Appl Physiol 95: 2292-2298, 2003. First published August 8, 2003 10.1152/japplphysiol. 00594.2003.-Spontaneously hypertensive heart failure (SHHF) rats develop hypertension and heart failure. We hypothesized that induction of hyperthyroidism should accelerate development of heart failure in male SHHF rats. Male and female SHHF rats received diets containing desiccated thyroid glands (DTG) or a control diet for 8 wk. Male and female Wistar-Kyoto rats were used as normotensive controls. DTG treatment reduced body weight in male, but not female, SHHF rats but increased body temperature and heart weight-to-body weight ratio in both genders. In DTGtreated male SHHF rats, serum triiodothyronine levels doubled relative to SHHF controls, whereas O2 consumption increased in DTG-treated SHHF rats. Frequency of breathing in air increased in DTG-treated female rats, and ventilation increased in DTG-treated male rats. Ventilatory equivalents exhibited gender differences in SHHF rats, were decreased in both genders by DTG treatment, and reached levels similar to those of Wistar-Kyoto rats. DTG increased heart rate, right ventricular pressure, and contractility in both genders and increased left ventricular pressure in SHHF male rats. These results refute our hypothesis and suggest that cardiopulmonary function of SHHF male rats may be improved by DTG treatment.hypertension; sick euthryoid syndrome; hyperthyroidism SPONTANEOUSLY HYPERTENSIVE heart failure (SHHF) rats were originally derived from a cross between the spontaneously hypertensive rat (SHR) and the Koletsky obese rat. Subsequently, these animals were bred with SHR-N (an SHR colony at the National Institutes of Health) (27). Lean male SHHF rats die between 15 and 20 mo of age, and lean females die between 22 and 26 mo of age. Although gender differences in the development of heart failure and hypertension have been examined in this strain (11,12,18,28,36), control of breathing has not been investigated.An additional stressor on the cardiopulmonary system is thyroid hormone dysfunction. For example, hyperthyroidism increases the metabolic demands of the body and stresses the cardiovascular and respiratory systems (22,29). In contrast, patients with heart failure can actually exhibit a "sick euthryoid" syndrome, characterized by decreased or normal levels of triiodothyronine (T 3 ) and increased levels of reverse T 3 (9, 23, 35). The possibility of using thyroid hormone replacement as a therapeutic measure has been approached in patients with heart failure (13, 23). Thus, increasing thyroid levels in SHHF rats may actually improve their cardiopulmonary status.In this study, we investigated the effects of experimentally induced hyperthyroidism in male and female SHHF rats on control of breathing and cardiac function. Gender-matched Wistar-Kyoto (WKY) rats were used as normotensive, euthryoid controls. We hypothesized that the combined effects of hyperthyroidism and hypertension would ...

show abstract

Naloxone Microinjected into the Arcuate Nucleus Has Differential Effects on Ventilation in Male and Female Rats

Cited by 15 publications

References 27 publications

Sex Differences in Salivary Cortisol Levels Following Naltrexone Administration1

Sex Differences in Salivary Cortisol Levels Following Naltrexone Administration1

Sex differences in development of morphine tolerance and dependence in the rat

Gender-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats

Contact Info

Product

Resources

About