Nano-biocomposite scaffolds of chitosan, carboxymethyl cellulose and silver nanoparticle modified cellulose nanowhiskers for bone tissue engineering applications

Hasan, Abshar; Waibhaw, Gyan; Saxena, Varun; Pandey, Lalit M.

doi:10.1016/j.ijbiomac.2018.01.089

Cited by 201 publications

(86 citation statements)

References 63 publications

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“…The bionanocomposite scaffold exhibited excellent antimicrobial activity also supported MG63 cells adhesion and proliferation. The incorporation of carboxymethyl cellulose also improved bio‐mineralization for bone growth . Carbon dots conjugated carboxymethyl cellulose hydroxyapatite nanocomposite was synthesized by a one‐pot synthesis for multiple applications like metal ion sensing, osteogenic activity, bio‐imaging, and drug carrier.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Amalraj¹,

Gopi²,

Thomas

et al. 2018

Macromolecular Symposia

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Nanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made various nanocomposite materials an intriguing prospect for different application in the biomedical, food, and nutraceutical industries. In this review, we have discussed and provided a summary of the recent researches in the utilization of cellulosic nanomaterials in applications related to food packaging, bone tissue engineering, wound dressing, drug delivery, and nutraceutical research area and industries.

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Section: Introductionmentioning

confidence: 99%

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Amalraj¹,

Gopi²,

Thomas

et al. 2018

Macromolecular Symposia

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“…The highly porous scaffolds exhibited good protein adsorption and antibacterial activity against E. coli and E. hirae. Incorporation of AgNP improved mechanical strength and showed no negative influence on MG-63 cell compatibility tests [146]. Comparable results are found for AgNPs incorporated together with HA in an alginate-chitlac (lactose-derivatized chitosan) matrix, as the resulting microbeads show bactericidal effects against S. aureus, P. aeruginosa, and S. epidermis, while preserving biocompatibility towards osteoblast-like cells [147].…”

Section: Miscellaneous Additivesmentioning

confidence: 84%

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

et al. 2019

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Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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“…The coated composite enhanced the osteoconductivity and biocompatibility of the implant and can be used as an effective treatment for diabetic‐induced impaired osteointegration . The sustained release of Ag particles embedded in CS/Hap‐coated NiTi alloy has been shown to inhibit bacterial growth …”

Section: Cs As a Surface Modifier In Btementioning

confidence: 99%

Chitosan in Surface Modification for Bone Tissue Engineering Applications

Abinaya

Prasith

Ashwin

et al. 2019

Biotechnology Journal

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Traditional methods of bone defect repair include autografts, allografts, surgical reconstruction, and metal implants that have several disadvantages such as donor site morbidity, rejection, risk of disease transmission, and repetitive surgery. Biomaterial‐based bone reconstructions can, therefore, be an efficient alternative due to the inherent properties of the materials. Chitosan (CS), the deacetylated form of chitin, is a biopolymer having a wide array of applicability in regenerative tissue applications owing to its biocompatible, in vitro degradative and bioresorbable nature. Extensive studies are being carried out using CS to augment the properties of the already existing methods and to also improve the applicability of CS‐based biocomposites in bone tissue repair. In this review, the suitability of CS as a surface modifier has been discussed in detail for the already existing implants, surface modifications of CS‐based natural biocomposites for bone tissue regeneration, and the wide range of techniques that can introduce these modifications. CS, being a natural polymer, possesses advantageous properties including surface modifier that makes it a suitable candidate for bone regeneration, and further research to investigate its osteogenic potential in vivo along with the molecular and signaling mechanisms involved in bone regeneration can aid in expanding its applicability in clinical trials.

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Nano-biocomposite scaffolds of chitosan, carboxymethyl cellulose and silver nanoparticle modified cellulose nanowhiskers for bone tissue engineering applications

Cited by 201 publications

References 63 publications

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

Chitosan in Surface Modification for Bone Tissue Engineering Applications

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