Nano-hydroxyapatite/polyacrylamide composite hydrogels with high mechanical strengths and cell adhesion properties

Li, Zhiyong; Mi, Wenying; Wang, Huiliang; Su, Yunlan; He, Changcheng

doi:10.1016/j.colsurfb.2014.10.050

Cited by 54 publications

(32 citation statements)

References 29 publications

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“…Several studies have combined polymers and nHap to create composite hydrogels, merging the desirable properties of the different organic and inorganic phases in order to achieve a synergistic effect in the resultant composite properties including the enhancement of the mechanical properties. Li et al developed nHap/polyacrylamide composite hydrogels that presented higher fracture tensile stress, higher extensibility, and higher compressive strength (35.8 MPa with 15% nHap vs. 22 MPa for pure gel) in comparison to the parent hydrogels; furthermore, these composites showed excellent shape recovery [52]. The authors justified the enhanced mechanical properties as the result of the chelating effect and the hydrogen bonding between the polymer chains and nHap particles.…”

Section: Hydrogels As Scaffolds and Delivery Platformsmentioning

confidence: 99%

Composite Hydrogels for Bone Regeneration

et al. 2016

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Over the past few decades, bone related disorders have constantly increased. Among all pathological conditions, osteoporosis is one of the most common and often leads to bone fractures. This is a massive burden and it affects an estimated 3 million people only in the UK. Furthermore, as the population ages, numbers are due to increase. In this context, novel biomaterials for bone fracture regeneration are constantly under development. Typically, these materials aim at favoring optimal bone integration in the scaffold, up to complete bone regeneration; this approach to regenerative medicine is also known as tissue engineering (TE). Hydrogels are among the most promising biomaterials in TE applications: they are very flexible materials that allow a number of different properties to be targeted for different applications, through appropriate chemical modifications. The present review will focus on the strategies that have been developed for formulating hydrogels with ideal properties for bone regeneration applications. In particular, aspects related to the improvement of hydrogels’ mechanical competence, controlled delivery of drugs and growth factors are treated in detail. It is hoped that this review can provide an exhaustive compendium of the main aspects in hydrogel related research and, therefore, stimulate future biomaterial development and applications.

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Section: Hydrogels As Scaffolds and Delivery Platformsmentioning

confidence: 99%

Composite Hydrogels for Bone Regeneration

et al. 2016

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“…Recently, a few approaches have focused on engineering bioactive hydrogels by combining nHAp with hydrophilic polymers such as poly(ethylene glycol) (PEG), polyacrylamide (PAAm), poly(vinyl alcohol) (PVA), alginate, carrageenan, gelatin, and collagen . This variety of polymers has expanded the use of nHAp in nanocomposite hydrogels, allowing for tailored functionality .…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinkable and elastomeric hydrogels for bone regeneration

Thakur

Xavier

Cross

et al. 2016

J Biomedical Materials Res

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Nanocomposite biomaterials are extensively investigated for cell and tissue engineering applications due their unique physical, chemical and biological characteristics. Here, we investigated the mechanical, rheological, and degradation properties of photocrosslinkable and elastomeric nanocomposite hydrogels from nanohydroxyapatite (nHAp) and gelatin methacryloyl (GelMA). The addition of nHAp resulted in a significant increase in mechanical stiffness and physiological stability. Cells readily adhere and proliferate on the nanocomposite surfaces. Cyclic stretching of cells on the elastomeric nanocomposites revealed that nHAp elicited a stronger alignment response in the direction of strain. In vitro studies highlight enhanced bioactivity of nanocomposites as determined by alkaline phosphate (ALP) activity. Overall, the elastomeric and photocrosslinkable nanocomposite hydrogels can be used for minimally invasive therapy for bone regeneration.

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“…Patches from hydrogels, however, cannot be applied in high motion areas because they have low mechanical properties. There have been many attempts to improve their mechanical properties, such as chemical modification of the hydrogel structure, synthesis of new hydrogels or blending with other polymers …”

Section: Introductionmentioning

confidence: 99%

Hybrid transdermal drug delivery patch made from poly(p‐phenylene vinylene)/natural rubber latex and controlled by an electric field

Niamlang

Paradee

Sirivat

2018

Polymer International

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A flexible, natural rubber (NR) patch was developed for electrically controllable transdermal drug delivery. NR latex was crosslinked at various crosslinking ratios under the UV curing method. Ibuprofen (Ibu) was the model drug and was used as the dopant for poly(p‐phenylene vinylene) (PPV) acting as the drug encapsulating host. For the pristine Ibu‐loaded NR patch, the amount of Ibu permeation increased with decreasing crosslink density and increasing electrical potential. For the Ibu‐doped PPV/NR patch, the amount of Ibu release−permeation also increased with increasing electrical potential and was higher than that of the pristine NR matrices. Without an applied electric field, the drug remained attached to the PPV during an initial period of 6 h. Under an applied electric field, the oxidation state of the conductive polymer was altered, the iontophoretic effect, pore formation in the NR matrix, expansion of the pore size in hair follicles and PPV chain expansion combined to increase the Ibu release−permeation amount. Thus, the flexible PPV/NR transdermal drug delivery patch was demonstrated to be effective in drug release−permeation based on the strength of the electrical potential, the crosslinking density and the presence of PPV as the encapsulation host. © 2018 Society of Chemical Industry

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Nano-hydroxyapatite/polyacrylamide composite hydrogels with high mechanical strengths and cell adhesion properties

Cited by 54 publications

References 29 publications

Composite Hydrogels for Bone Regeneration

Composite Hydrogels for Bone Regeneration

Photocrosslinkable and elastomeric hydrogels for bone regeneration

Hybrid transdermal drug delivery patch made from poly(p‐phenylene vinylene)/natural rubber latex and controlled by an electric field

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