“Nano-lymphatic” photocatalytic water-splitting for relieving tumor interstitial fluid pressure and achieving hydrodynamic therapy

Cong, Cong; Rao, C. N. R.; Ma, Zhenhe; Yu, Menghan; He, Yaqian; He, Yuchu; Hao, Zining; Li, Chunhui; Li, Hongming; Gao, Dawei

doi:10.1039/d0mh01295e

Cited by 32 publications

(27 citation statements)

References 37 publications

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“…The hypoxia-inducible factor-1α (HIF-1α) was quickly degraded by the intracellular oxygen-dependent ubiquitin-protease degradation pathway in normal oxygenated cells. 13 HIF-1α expression was stable only under hypoxia conditions, so we monitored the expression of HIF-1α to reflect hypoxia in the tumor sites. Tumor tissue showed activation of TPZ by hypoxia, and the oxygen content of normal tissue was much higher than that of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy

Zhang

Liu

2022

Technol Cancer Res Treat

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The tumor microenvironment is complex and changeable, so the design of a nano-delivery system for the tumor microenvironment has attracted wide attention. Based on this, we designed an intelligent nano-reactor for the characteristics of acidic pH and hypoxia in the tumor microenvironment. Firstly, the silver nano-balls were synthesized by the biological template method, which exhibited a good photothermal conversion efficiency and can realize the photothermal treatment of tumor sites. Subsequently, the hypoxic prodrug tirapazamine (TPZ) and polydopamine (PDA) for chemotherapy were self-assembled. After PDA arrived at the tumor site (pH 5.5) from the normal physiological environment (pH 7.4), the hypoxic prodrug TPZ was released in pH response by PDA. Subsequently, TPZ selectively induced obvious cell damage under tumor hypoxia stimulation but had no toxic effect on normal cells under normal oxygen. In addition, the nano-converter was loaded with iRGD on the surface, which enhanced the targeted delivery of the nano-reactor to achieve a highly effective antitumor effect. The nano-reactor was capable of combining photothermal/chemotherapy therapy. Importantly, it can selectively kill tumor cells without damaging normal cells based on the characteristics of the tumor microenvironment, with high bio-safety and clinical transformation potential.

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Section: Discussionmentioning

confidence: 99%

Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy

Zhang

Liu

2022

Technol Cancer Res Treat

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“…This nanomedicine mimics lymphatic in releasing tumor interstitial uid and is termed as "Nano-lymphatic". In the previous report, we have preliminarily showcased the feasibility of the tumor interstitial uid decomposition and decrease of TIFP by photocatalysis 19 .…”

Section: Introductionmentioning

confidence: 99%

“…This nanomedicine mimics lymphatic in releasing tumor interstitial fluid and is termed as “Nano-lymphatic”. In the previous report, we have preliminarily showcased the feasibility of the tumor interstitial fluid decomposition and decrease of TIFP by photocatalysis . Nevertheless, the catalytic nanomedicine system could only be excited by the high-energy ultraviolet–visible (UV-vis) light, which highly restricted its application in vivo , because of the weak tissue penetration of UV-vis light. − Therefore, we proposed an ideal and unexplored strategy to address the problem: reducing TIP by pyroelectric catalysis.…”

Section: Introductionmentioning

confidence: 99%

“…Because the basis of tumor interstitial fluid is water, the decomposition of water can effectively reduce the volume of tumor interstitial fluid, meaning a decrease in TIFP. 19 Our group has designed a photocatalytic nanomedicine system to reduce TIFP, inspired by the catalytic water splitting employed in the field of new energy. 20 This nanomedicine mimics lymphatic in releasing tumor interstitial fluid and is termed as "Nano-lymphatic".…”

Section: Introductionmentioning

confidence: 99%

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Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Cong

et al. 2021

ACS Nano

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Owing to de ciency of lymphatic re ux in the tumor, the retention of tumor interstitial uid causes the aggravation of tumor interstitial pressure (TIP), which leads to unsatisfactory tumor penetration of nanomedicine. It is the main inducement of tumor recurrence and metastasis. Herein, we design a pyroelectric catalysis-based "Nano-lymphatic" to decrease the TIP for enhanced tumor penetration and treatments. It realizes photothermal therapy and decomposition of tumor interstitial uid under NIR-II laser irradiation after reaching the tumor, which reduces the TIP for enhanced tumor penetration.Simultaneously, reactive oxygen species generated during the pyroelectric catalysis can further damage deep tumor stem cells. The results indicate that the "Nano-lymphatic" relieves 52% of TIP, leading to enhanced tumor penetration, which effectively inhibits the tumor proliferation (93.75%) and recurrence.Our nding presents a novel strategy to reduce TIP by pyroelectric catalysis for enhanced tumor penetration and improved treatments, which is of great signi cance for drug delivery.

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“…Photo‐activated metal complexes have been suggested to have remarkable potential for cancer treatment. [ 5–8 ] For instance, photocatalysis induces water splitting and thereby decreases the volume of tumor interstitial fluid, [ 9 ] while generating abundant reactive oxygen species (ROS) and O 2 to create a redox imbalance intracellularly. [ 10 ] Therefore, a combination of PTT and photocatalytic therapy may be effective in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets

Duo

Luo

et al. 2021

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Photothermal therapy (PTT) and photocatalytic therapy using near-infrared (NIR) laser radiation, which provide high specificity and efficiency, have gained extensive attention as noninvasive treatments for tumor destruction. PTT uses photo-absorbers with high photothermal conversion efficiency to convert light into heat and kill cancer cells via an increase in temperature. PTT requires temperatures over 50 °C to effectively destroy cancer cells. [2] Although such high temperatures may also cause thermal damage to healthy neighboring tissues owing to laser-induced nonspecific heat diffusion, [3] and high temperatures also cause cancer cells to release intracellular molecules that promote immunosuppression, which allows tumor immune escape, metastasis, invasion, and so on, [4] PTT is still an efficient method for obliterating cancer cells thoroughly. However, PTT is combined with other therapeutic approaches could achieve better therapeutic effects.As a novel photo-activated treatment, catalytic medicine has attracted increased attention in recent years for the management of many diseases. This technique allows specific bio-imaging and the administration of versatile therapies through physicochemical effects such as catalytic activity and energy conversion. Photo-activated metal complexes have been suggested to have remarkable potential for cancer treatment. [5][6][7][8] For instance, photocatalysis induces water Nanomaterial-based photothermal and photocatalytic therapies are effective against various types of cancers. However, combining two or more materials is considered necessary to achieve the synergistic anticancer effects of photothermal and photocatalytic therapy, which made the preparation process complicated. Herein, the authors describe simple 2D titanium diselenide (TiSe 2 ) nanosheets (NSs) that can couple photothermal therapy with photocatalytic therapy. The TiSe 2 NSs are prepared using a liquid exfoliation method. They show a layered structure and possess high photothermal conversion efficiency (65.58%) and good biocompatibility. Notably, upon near-infrared irradiation, these NSs exhibit good photocatalytic properties with enhanced reactive oxygen species generation and H 2 O 2 decomposition in vitro. They can also achieve high temperatures, with heat improving their catalytic ability to further amplify oxidative stress and glutathione depletion in cancer cells. Furthermore, molecular mechanism studies reveal that the synergistic effects of photothermal and enhanced photocatalytic therapy can simultaneously lead to apoptosis and necrosis in cancer cells via the HSP90/JAK3/NF-κB/IKB-α/ Caspase-3 pathway. Systemic exploration reveals that the TiSe 2 NSs has an appreciable degradation rate and accumulates passively in tumor tissue, where they facilitate photothermal and photocatalytic effects without obvious toxicity. Their study thus indicates the high potential of biodegradable TiSe 2 NSs in synergistic phototherapy for cancer treatment.

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“Nano-lymphatic” photocatalytic water-splitting for relieving tumor interstitial fluid pressure and achieving hydrodynamic therapy

Abstract: The advance of anti-tumor nanomedicines is restricted in the delivery efficiency owing to a lack of insight into the intratumoral delivery mechanism, especially traversing biological barriers. Herein, we explore a...

Cited by 32 publications

References 37 publications

Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy

Highly Active Nano-Reactor for Responding Tumor Microenvironment and Antitumor Therapy

Pyroelectric Catalysis-Based “Nano-Lymphatic” Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets

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