Nano-scale modification of titanium implant surfaces to enhance osseointegration

Souza, Júlio C. M.; Sordi, Mariane Beatriz; Kanazawa, M; Ravindran, Sriram; Henriques, Bruno; Silva, Filipe; Aparicio, Conrado; Cooper, Lyndon F.

doi:10.1016/j.actbio.2019.05.045

Cited by 412 publications

(320 citation statements)

References 231 publications

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“…Surface treatments, leaving unaltered the chemical-physical features of optimized devices, is presently the most deeply investigated aspect. Despite the extensively described correlation between micro/nano-scale features and osseointegration, the implant failure induced by microbial adhesion and biofilm accumulation is still an open question [44]. It is proven that titanium surfaces do not prevent bacterial adhesion by themselves [45] and their coating, either physical or covalent, with antimicrobial actives is a thriving and challenging field of research [28].…”

Section: Titanium Functionalization and Prevention Of Bacteria Adhesionmentioning

confidence: 99%

Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives

Piras

Esin

Benedetti

et al. 2019

IJMS

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In the era of antimicrobial resistance, the identification of new antimicrobials is a research priority at the global level. In this regard, the attention towards functional antimicrobial polymers, with biomedical/pharmaceutical grade, and exerting anti-infective properties has recently grown. The aim of this study was to evaluate the antibacterial, antibiofilm, and antiadhesive properties of a number of quaternized chitosan derivatives that have displayed significant muco-adhesive properties and wound healing promotion features in previous studies. Low (QAL) and high (QAH) molecular weight quaternized chitosan derivatives were synthetized and further modified with thiol moieties or pendant cyclodextrin, and their antibacterial activity evaluated as minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC). The ability of the derivatives to prevent biofilm formation was assessed by crystal violet staining. Both QAL and QAH derivatives exerted a bactericidal and/or inhibitory activity on the growth of P. aeruginosa and S. epidermidis. The same compounds also showed marked dose-dependent anti-biofilm activity. Furthermore, the high molecular weight derivative (QAH) was used to functionalize titanium plates. The successful functionalization, demonstrated by electron microscopy, was able to partially inhibit the adhesion of S. epidermidis at 6 h of incubation. The shown ability of the chitosan derivatives tested to both inhibit bacterial growth and/or biofilm formation of clinically relevant bacterial species reveals their potential as multifunctional molecules against bacterial infections.

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Section: Titanium Functionalization and Prevention Of Bacteria Adhesionmentioning

confidence: 99%

Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives

Piras

Esin

Benedetti

et al. 2019

IJMS

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“…For laser ablation, an implant whose collar, or neck area, was treated by laser micromachining to generate nano-channels is used (Laser-Lok, BioHorizons, Birmingham, AL, USA) [124,125]. Laser ablation is also able to produce micro-scale patterns by controlling laser processing parameters [126]. This approach was intended to promote not only fast osseointegration, but also connective tissue attachment [124,127].…”

Section: Laser Ablationmentioning

confidence: 99%

Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

2019

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This review paper describes several recent modification methods for biocompatible titanium dental implant surfaces. The micro-roughened surfaces reviewed in the literature are sandblasted, large-grit, acid-etched, and anodically oxidized. These globally-used surfaces have been clinically investigated, showing survival rates higher than 95%. In the past, dental clinicians believed that eukaryotic cells for osteogenesis did not recognize the changes of the nanostructures of dental implant surfaces. However, research findings have recently shown that osteogenic cells respond to chemical and morphological changes at a nanoscale on the surfaces, including titanium dioxide nanotube arrangements, functional peptide coatings, fluoride treatments, calcium–phosphorus applications, and ultraviolet photofunctionalization. Some of the nano-level modifications have not yet been clinically evaluated. However, these modified dental implant surfaces at the nanoscale have shown excellent in vitro and in vivo results, and thus promising potential future clinical use.

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“…Surface characteristics of implants-one of the principal factors affecting the process of osseointegration [10]-have been a topic of growing interest for decades. Various titanium surfaces with different micro-scale topography have been developed and studied [11][12][13][14]; however, many challenges remain, including difficulties in determining whether one particular implant surface is better than the others [15].…”

Section: Introductionmentioning

confidence: 99%

“…It is unclear whether and to what extent the nano-surface improves the osteoconductive and osseointegrative ability of biomaterials [30]; more importantly, nano-scale features have yet to be successfully formed on titanium materials or commercial implant products [31,32]. Although reports exist on the creation of nano-scale titanium surfaces [14,33,34], the nano-features did not present distinct or defined appearance. In addition, it is technically difficult to control nano-scale structure, prompting the need for further studies.…”

Section: Introductionmentioning

confidence: 99%

A Newly Created Meso-, Micro-, and Nano-Scale Rough Titanium Surface Promotes Bone-Implant Integration

Hasegawa

Saruta

Hirota

et al. 2020

IJMS

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Titanium implants are the standard therapeutic option when restoring missing teeth and reconstructing fractured and/or diseased bone. However, in the 30 years since the advent of micro-rough surfaces, titanium’s ability to integrate with bone has not improved significantly. We developed a method to create a unique titanium surface with distinct roughness features at meso-, micro-, and nano-scales. We sought to determine the biological ability of the surface and optimize it for better osseointegration. Commercially pure titanium was acid-etched with sulfuric acid at different temperatures (120, 130, 140, and 150 °C). Although only the typical micro-scale compartmental structure was formed during acid-etching at 120 and 130 °C, meso-scale spikes (20–50 μm wide) and nano-scale polymorphic structures as well as micro-scale compartmental structures formed exclusively at 140 and 150 °C. The average surface roughness (Ra) of the three-scale rough surface was 6–12 times greater than that with micro-roughness only, and did not compromise the initial attachment and spreading of osteoblasts despite its considerably increased surface roughness. The new surface promoted osteoblast differentiation and in vivo osseointegration significantly; regression analysis between osteoconductivity and surface variables revealed these effects were highly correlated with the size and density of meso-scale spikes. The overall strength of osseointegration was the greatest when the acid-etching was performed at 140 °C. Thus, we demonstrated that our meso-, micro-, and nano-scale rough titanium surface generates substantially increased osteoconductive and osseointegrative ability over the well-established micro-rough titanium surface. This novel surface is expected to be utilized in dental and various types of orthopedic surgical implants, as well as titanium-based bone engineering scaffolds.

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Nano-scale modification of titanium implant surfaces to enhance osseointegration

Cited by 412 publications

References 231 publications

Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives

Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives

Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

A Newly Created Meso-, Micro-, and Nano-Scale Rough Titanium Surface Promotes Bone-Implant Integration

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