Nano-technology in herbal medicines: A review

Chakraborty, Krishnasis; Shivakumar, Arun; Ramachandran, S.

doi:10.22271/flora.2016.v4.i3.05

Cited by 53 publications

(18 citation statements)

References 28 publications

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“…They also allow controlled release and targeting to specific organs or tissues, improving their performance via increasing their bioavailability and reducing their undesirable side effects. The nanosize of these components and their engineered surface helps them pass through the vessels to reach a specific organ [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. Thus, nanocarriers have been extensively used for the encapsulation of different phytochemicals, including NRG or naringin which is its glycosidic form [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ].…”

Section: Introductionmentioning

confidence: 99%

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

et al. 2021

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Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nanoemulsions. These nanomedicine formulations of NRG have been applied as a potential treatment for several diseases, using a wide range of in vitro, ex vivo, and in vivo models and different routes of administration. From this review, it can be concluded that NRG is a potential therapeutic option for the treatment of various diseases such as cancer, neurological disorders, liver diseases, ocular disorders, inflammatory diseases, skin diseases, and diabetes when formulated in the appropriate nanocarriers.

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Section: Introductionmentioning

confidence: 99%

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

et al. 2021

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“…In addition to this it also counteract the limitations of lower absorption and lack of specificity experienced by the available formulation of drugs. Advantages of novel drug delivery system over the presently available drug therapy is that it is specific, has rapid onset of action with faster absorption due to enhanced surface area and lastly nanoparticles provides better penetration in Blood Brain Barrier (BBB) [33].…”

Section: Novel Approaches For Antifungal Plant Components and Their Ementioning

confidence: 99%

Medicinal Plants Having Antifungal Properties

Mishra¹,

Kaur²,

Sahu³

et al. 2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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In the past few decades, a worldwide increase in the incidence of fungal infections has been observed as well as rise in the resistance of some species of fungi to different fungicidal used in medicinal practice. Besides, fungi are the one of the most neglected pathogens as demonstrated by the fact that the amphotericin B and other sold treatments are still used as gold standard as antifungal therapy. The majority of used antifungal treatments have various drawbacks in terms of toxicity, efficacy as well as cost and their frequent use has also led to the emergence of resistant strains. Hence, there is a great demand for developing an antifungal belonging to a wide range of structural classes, selectively acting on new targets with least side effects. Natural products, either as pure phytocompounds or as standardized plant extracts, provide unlimited opportunities for new drug lads because of their having normally matchless chemical diversity. Present chapter focused on the work done in the field of antifungal activities of various plant components and novel approaches which will be the future prospective for the new drug discoveries and providing better antifungal therapy.

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“…At present, health-care costs must also be considered. This reduction in health-care costs is likely to be obtained by increasing nanotherapeutic efficacy, reducing its length hospitalization, reducing personal healthcare costs, and effective treatment of major expensive diseases [26]. Subsequent studies must be conducted to determine the factors that lead to increased delivery efficiency and bioavailability.…”

Section: Characterizations Of Snedds Of Extract Singawalang Leavesmentioning

confidence: 99%

Formulation and Characterizations of Self-Nanoemulsifying Drug Delivery System of Extract Petiveria Alliacea (Singawalang) Leaves

2019

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Objective: Formulation of Singawalang leaves extract should be considered because the extract contains a variety of compounds so that there maybe a competitor in the absorption process and will cause the absorption of active ingredients in the gastrointestinal decline. One way to increase theabsorption and disposition of active ingredients on target organs is to use a nanoparticle formulation. Therefore, this study will conduct research onself-nanoemulsifying drug delivery system (SNEDDS) formulation of Singawalang (Petiveria alliacea) leaves extract.Methods: The systems were developed by investigating the solubility Singawalang leaves extract in various carrier oil, the suitable surfactant,and cosurfactant, construction of SNEDDS of Singawalang leaves extract and characterization of droplet size through particle size analyzer andtransmission electron microscopy.Results: The results of this study indicate that the optimum carrier oils for Singawalang leave extract are miglitol and virgin coconut oil (VCO),the compatible surfactant component is tween 80 and the compatible cosurfactant is propylene glycol (PG). The average droplet size is 13 nm andpolydisperse index 0,004 and 0,006.Conclusion: It can be concluded, the present study demonstrated that the optimum SNEDDS formulations of Singawalang leave extract are themixture of VCO, tween 80, PG at ratio 1:8:1 and miglitol, tween 80, and PG at ratio 2:5:3.

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Nano-technology in herbal medicines: A review

Cited by 53 publications

References 28 publications

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

Medicinal Plants Having Antifungal Properties

Formulation and Characterizations of Self-Nanoemulsifying Drug Delivery System of Extract Petiveria Alliacea (Singawalang) Leaves

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