Formulation and Characterizations of Self-Nanoemulsifying Drug Delivery System of Extract Petiveria Alliacea (Singawalang) Leaves

Abstract

Objective: Formulation of Singawalang leaves extract should be considered because the extract contains a variety of compounds so that there maybe a competitor in the absorption process and will cause the absorption of active ingredients in the gastrointestinal decline. One way to increase theabsorption and disposition of active ingredients on target organs is to use a nanoparticle formulation. Therefore, this study will conduct research onself-nanoemulsifying drug delivery system (SNEDDS) formulation of Singawalang (Petiveria alliacea) leaves extract.Methods: The systems were developed by investigating the solubility Singawalang leaves extract in various carrier oil, the suitable surfactant,and cosurfactant, construction of SNEDDS of Singawalang leaves extract and characterization of droplet size through particle size analyzer andtransmission electron microscopy.Results: The results of this study indicate that the optimum carrier oils for Singawalang leave extract are miglitol and virgin coconut oil (VCO),the compatible surfactant component is tween 80 and the compatible cosurfactant is propylene glycol (PG). The average droplet size is 13 nm andpolydisperse index 0,004 and 0,006.Conclusion: It can be concluded, the present study demonstrated that the optimum SNEDDS formulations of Singawalang leave extract are themixture of VCO, tween 80, PG at ratio 1:8:1 and miglitol, tween 80, and PG at ratio 2:5:3.

Design and Characterization of Nanospray With Self-Nanoemulsifying Drug Delivery System Using Sinergistic Combination of Melastoma Malabathricum L. Fraction and Gentamicin

“…Propylene glycol as cosurfactant had a major influence on emulsification time. Mustika et al (2019) showed that the dispersion ability of propylene glycol±15 s was included in category A [18], capable to produce a nanoemulsion quickly in about 1 min [19] with a clear nanoemulsion display. This is in accordance with the results obtained in this study.…”

The self-nanoemulsifying drug delivery system of Petiveria alliacea extract reduced the homeostatic model assessment-insulin resistance value, interleukin-6, and tumor necrosis factor-α level in diabetic rat models

“…The SNEDDS formulation was formed from virgin coconut oil, Tween 80, and propylene glycol. The SNEDDS of P. alliacea leaf extract was made by adding P. alliacea leaf extract to the SNEDDS formulation [21].…”

“…One of the disadvantages of P. alliacea leaf extract is that it contains complex active compounds, which may compete in the absorption process, resulting in a decline in the absorption of active compounds in the gastrointestinal tract [19,20]. Therefore, to overcome this problem, P. alliacea extract formulated in the form of a self-emulsifying drug delivery system (SNEDDS) is made [21]. The evaluation of the SNEDDS formulation of P. alliacea leaf extract on the diabetes treatment has not yet been clearly elucidated.…”