Nano-TiO2 enhances the toxicity of copper in natural water to Daphnia magna

Fan, Wenhong; Cui, Minming; Liu, Hong; Wang, Chuan; Shi, Zhiwei; Tan, Cheng; Yang, Xiuping

doi:10.1016/j.envpol.2010.11.030

Cited by 160 publications

(103 citation statements)

References 34 publications

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“…Rainbow trout treated with 1 mg/L of TNPs for 14 days showed pathologic alterations in the gills (edema and thickening of gill lamellae) as well as oxidative stress, dose/timedependent inhibition of growth, and changes in Cu and Zn levels in tissues [85]. Further, TNPs have a stronger adsorptive capacity for metal ions (e.g., Cu, Cd) than do sediment particles [86,87]. In carp, for example, the presence of TNPs significantly enhanced accumulation of toxic metal ions in the viscera and gills [87].…”

Section: Tnp Toxicity To Organisms In the Ecosystemmentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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Section: Tnp Toxicity To Organisms In the Ecosystemmentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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“…Overexposure, especially a sublethal dose exposure of Cu, could induce immunotoxicity in mice, including cell-cycle arrest and cell death in the spleen and thymus. 34 Fan et al 35 found that TiO 2 NPs (at a concentration generally considered to be safe in the environment) remarkably enhanced the toxicity of Cu on Daphnia magna by increasing the bioaccumulation of Cu. In addition, they found that the Cu was adsorbed on to the TiO 2 NPs when ingested and was accumulated in the animals, thereby causing an increase in toxic effects.…”

Section: Effects Of Tio 2 Np Interaction With Metals and Their Compoundsmentioning

confidence: 99%

Toxic effects of the interaction of titanium dioxide nanoparticles with chemicals or physical factors

Liu

Lin²,

Zhao

2013

IJN

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Due to their chemical stability and nonallergic, nonirritant, and ultraviolet protective properties, titanium dioxide (TiO 2 ) nanoparticles (NPs) have been widely used in industries such as electronics, optics, and material sciences, as well as architecture, medicine, and pharmacology. However, increasing concerns have been raised in regards to its ecotoxicity and toxicity on the aquatic environment as well as to humans. Although insights have been gained into the effects of TiO 2 NPs on susceptible biological systems, there is still much ground to be covered, particularly in respect of our knowledge of the effects of the interaction of TiO 2 NPs with other chemicals or physical factors. Studies suggest that interactions of TiO 2 NPs with other chemicals or physical factors may result in an increase in toxicity or adverse effects. This review highlights recent progress in the study of the interactive effects of TiO 2 NPs with other chemicals or physical factors.

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“…Prior to the assay, the daphnids were selected according to their size and kept in fresh water under continuous aeration. The bioassay was performed according to the method described in the study by Fan et al (38) with some modifications (39). Ten daphnids were inserted in 10 ml graduated test tubes, and the plant extracts were added in synthetic media in order to obtain solutions of 1,000, 1,500, 2,000, 2,500 and 3,000 µg extract/ml.…”

Section: Assessment Of Toxicitymentioning

confidence: 99%

Anticancer potential of selected Fallopia Adans species

et al. 2015

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Abstract. The aim of the present study was to determine the anticancer potential of three species belonging to the Fallopia genus (Polygonaceae): Fallopia convolvulus (F. convolvulus, Fallopia dumetorum (F. dumetorum) and Fallopia aubertii (F. aubertii). For this purpose, crude extracts were obtained and characterized for their phenolic and flavonoid total content and examined for their anticancer activity on three tumor cell lines: breast cancer (MCF7), colon carcinoma (Caco-2) and cervical cancer (HeLa) cells. The cytotoxic potential of the three species was assessed by MTT assay, cell cycle analysis and by the evaluation of mitochondrial membrane potential (MMP). The acute toxicity of the extracts was evaluated using one in vitro cell model (Vero cells, an African Green monkey kidney cell line) and two invertebrate in vivo models (Daphnia magna and Artemia salina). The highest total phenolic and flavonoid content was found in the F. aubertii flower extracts. The cytotoxic effects of the extracts from F. aubertii and F. convolvulus on all three cell lines were examined at concentrations ranging from 3 to 300 µg/ml. G2/M cell cycle arrest was induced by all the extracts, and a significant increase in the subG1 cell population was observed. The hydroethanolic extract from the flowers of F. aubertii induced cell apoptosis more rapidly than the other extracts. The MMP indicates the involvement of the mitochondria in the induction of apoptosis. A positive correlation between the total phenolic content of the extracts and the IC 50 values against the HeLa cells was also noted. None of the extracts exhibited significantly toxic effects. Considering the antitumor potential of F. aubertii and F. convolvulus, these two species may represent a good source of plant extracts with anticancer properties. IntroductionCancer is the main cause of mortality and morbidity in Europe following cardiovascular diseases and represents the uncontrolled growth and spread of cells that arises from a change in one single cell (1). Each year, millions of individuals are diagnosed with cancer. The disease accounts for the death of approximately 3.5 million individuals annually worldwide (2). It was estimated that only in Europe, in 2012, 3.45 million new cases of cancer were noted, excluding non-melanoma skin cancer, and 1.75 million deaths occurred from cancer (3).Throughout history, plant extracts and their purified active components have been the backbone of cancer chemotherapeutics (4). Additionally, structural analogues have been obtained by molecular modifications of the natural compounds and have reinforced the anticancer arsenal (5). It is estimated that over 70% of anticancer compounds are either natural products, or natural product-derived substances (6). The rich diversity of the chemical structures provided by natural resources offers valuable templates for exploring novel molecular scaffolds and is the most significant source of new drug developments (7).Over the past two decades, flavonoid-rich plant extracts and isolated flav...

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Nano-TiO2 enhances the toxicity of copper in natural water to Daphnia magna

Cited by 160 publications

References 34 publications

The potential health risk of titania nanoparticles

The potential health risk of titania nanoparticles

Toxic effects of the interaction of titanium dioxide nanoparticles with chemicals or physical factors

Anticancer potential of selected Fallopia Adans species

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