Nanocapsule-mediated sustained H2 release in the gut ameliorates metabolic dysfunction-associated fatty liver disease

Jin, Zhaokui; Sun, Yuan; Tian, Yang; Tan, Liwen; Lv, Peixun; Xu, Qingqing; Tao, Geru; Qin, Shucun; Lu, Xifeng; He, Qianjun

doi:10.1016/j.biomaterials.2021.121030

Cited by 31 publications

(23 citation statements)

References 46 publications

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“…Qiu et al showed that saturated hydrogen saline treatment could modulate the abundance of Bacteroides , Bifidobacteria , and Lactobacillus in feces, which may responsible for the improvement of lipid metabolism disorders in high-fat diet mice 34 . Jin et al reported that sustained H 2 release in the gut by hydrogen nanocapsule could increase the abundance of Akkermansia muciniphila and attenuate metabolic dysfunction-associated fatty liver disease 35 . In this study, HRW intake induced significant changes in the structure of gut microbiota, while no marked bacterial community differences was observed in HI group.…”

Section: Discussionmentioning

confidence: 99%

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Xie

Jiang

et al. 2022

Sci Rep

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The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochemical parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen consumption, the plasma metabolome and gut microbiota were investigated in this study. Compared with the control group, 14 and 10 differential metabolites (DMs) were identified in hydrogen-rich water (HRW) and hydrogen inhalation (HI) group, respectively. Pathway enrichment analysis showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. 16S rRNA gene sequencing showed that HRW intake induced significant changes in the structure of gut microbiota, while no marked bacterial community differences was observed in HI group. HRW intake mainly induced significant increase in the abundance of Lactobacillus, Ruminococcus, Clostridium XI, and decrease in Bacteroides. HI mainly induced decreased abundances of Blautia and Paraprevotella. The metabolic function was determined by metabolic cage analysis and showed that HI decreased the voluntary intake and excretions of rats, while HRW intake did not. The results of this study provide basic data for further research on hydrogen medicine. Determination of the effects of hydrogen intervention on microbiota profiles could also shed light on identification of mechanism underlying the biological effects of molecular hydrogen.

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Section: Discussionmentioning

confidence: 99%

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Xie

Jiang

et al. 2022

Sci Rep

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“…An oral H 2 nanocapsule (AB@hMSN@PEG) was synthesized via loading ammonia borane (AB) into hMSN, which was further modified with PEG (Figure 6C‐i). [ 133 ] The nanocapsules achieved a super high H 2 ‐loading capacity for effective H 2 delivery (50 mg AB@hMSN@PEG equals 3.9 L H 2 ‐rich water). After injection of AB@hMSN@PEG into the fatty liver mice model, H 2 was continuously released in response to the gastric acid and significantly reduced fat content without influencing the bodyweight of mice.…”

Section: H2‐generating Ggnsmentioning

confidence: 99%

“…For example, O 2 and H 2 are measured in vitro utilizing a dissolved O 2 meter and needle-type H 2 sensor. [30,51,52,[60][61][62]128,131,133] In addition, H 2 content in vivo can also be detected by a needle-type H 2 sensor, which can provide a concentration reference range for future H 2 therapy. [128] These methods were convenient and can directly read the amount of gas generated.…”

Section: Gas Production Detection Of Ggnsmentioning

confidence: 99%

“…Ischemia− reperfusion injury therapy [128] AB@hMSN@PEG 41.72% 10 × 10 −6 m (1.2 mg mL −1 of AB@hMSN@PEG) 120 mg kg −1 of AB@hMSN@PEG (intragastric administration, 6 × 10 −6 m H 2 in blood) Fatty liver disease therapy [133] H 2 S 0.11 × 10 −3 m 0.36 × 10 −6 m gas inhalation concentration MnS@BSA / 92% (5.5 × 10 −3 m of MnS@BSA)…”

Section: Introductionmentioning

confidence: 99%

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The Advancement of Gas‐Generating Nanoplatforms in Biomedical Fields: Current Frontiers and Future Perspectives

et al. 2022

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Diverse gases (NO, CO, H2S, H2, etc.) have been widely applied in the medical intervention of various diseases, including cancer, cardiovascular disease, ischemia‐reperfusion injury, bacterial infection, etc., attributing to their inherent biomedical activities. Although many gases have many biomedical activities, their clinical use is still limited due to the rapid and free diffusion behavior of these gases molecules, which may cause potential side effects and/or ineffective treatment. Gas‐generating nanoplatforms (GGNs) are effective strategies to address the aforementioned challenges of gas therapy by preventing gas production or release at nonspecific sites, enhancing GGNs accumulation at targeted sites, and controlling gas release in response to exogenous (UV, NIR, US, etc.) or endogenous (H2O2, GSH, pH, etc.) stimuli at the lesion site, further maintaining gas concentration within the effective range and achieving the purpose of disease treatment. This review comprehensively summarizes the advancements of “state‐of‐the‐art” GGNs in the recent three years, with emphasis on the composition, structure, preparation process, and gas release mechanism of the nanocarriers. Furthermore, the therapeutic effects and limitations of GGNs in preclinical studies using cell/animal models are discussed. Overall, this review enlightens the further development of this field and promotes the clinical transformation of gas therapy.

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“…Molecular hydrogen is both a clean and green energy source and a well-proven biosafe and effective medical gas, demonstrating a NO-similar wide-spectrum therapeutic effect in a variety of oxidative stress (OS)-related diseases such as ischemic tissue injury, cardiovascular disease, metabolic syndrome, cancer and so on, [1][2][3][4][5][6][7][8] owing to its selective anti-oxidation ability. [2] In addition, molecular hydrogen also is a green and efficient agricultural gas that has significant anti-OS biological effects in enhancement of various tolerances (drug, drought, heavy metals, and salt stress), increase crop yields and freshness preservation.…”

Section: Introductionmentioning

confidence: 99%

An Activity‐Based Ratiometric Fluorescent Probe for In Vivo Real‐Time Imaging of Hydrogen Molecules

et al. 2022

Self Cite

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To reveal the biomedical effects and mechanisms of hydrogen molecules urgently needs hydrogen molecular imaging probes as an imperative tool, but the development of these probes is extremely challenging. A catalytic hydrogenation strategy is proposed to design and synthesize a ratiometric fluorescent probe by encapsulating Pd nanoparticles and conjugating azido-/coumarin-modified fluorophore into mesoporous silica nanoparticles, realizing in vitro and in vivo fluorescence imaging of hydrogen molecules. The developed hydrogen probe exhibits high sensitivity, rapid responsivity, high selectivity and low detection limit, enabling rapid and real-time detection of hydrogen molecules both in cells and in the body of animal and plant. By application of the developed fluorescent probe, we have directly observed the super-high transmembrane and ultrafast transport abilities of hydrogen molecules in cells, animals and plants, and discovered in vivo high diffusion of hydrogen molecules.

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Nanocapsule-mediated sustained H2 release in the gut ameliorates metabolic dysfunction-associated fatty liver disease

Cited by 31 publications

References 46 publications

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status

The Advancement of Gas‐Generating Nanoplatforms in Biomedical Fields: Current Frontiers and Future Perspectives

An Activity‐Based Ratiometric Fluorescent Probe for In Vivo Real‐Time Imaging of Hydrogen Molecules

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