Nanocarrier: A potential tool for future antioxidant therapy

Du, Libo; Li, J; Chen, C; Liu, Y

doi:10.3109/10715762.2014.924625

Cited by 22 publications

(12 citation statements)

References 69 publications

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“…Nevertheless, the traditional antioxidants still face some challenges such as poor stability, high toxicity, and low bioavailability. [ 40–42 ] In recent years, with the development of nanotechnology and nanoscience, novel antioxidant strategies based on multifunctional nanomaterials are widely applied in the construction of ROS scavengers, providing a new opportunity for the development of traditional antioxidant therapy to overcome oxidative stress injuries. Currently, great efforts in ROS‐scavenging nanomedicines have been devoted ( Table 1 ).…”

Section: Ros‐associated Nanomedicines For Disease Treatmentsmentioning

confidence: 99%

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

et al. 2020

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Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving the topics in ROS‐regulating therapy such as antioxidant therapy triggered by ROS scavengers and ROS‐induced toxic therapy mediated by ROS‐elevation agents. Benefiting from the remarkable advances of nanotechnology, a large number of nanomaterials with the ROS‐regulating ability are developed to seek new and effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements have been made in ROS‐based nanomedicines for disease treatments, some fundamental but key questions such as the rational design principle for ROS‐related nanomaterials are held in low regard. Here, the design principle can serve as the initial framework for scientists and technicians to design and optimize the ROS‐regulating nanomedicines, thereby minimizing the gap of nanomedicines for biomedical application during the design stage. Herein, an overview of the current progress of ROS‐associated nanomedicines in disease treatments is summarized. And then, by particularly addressing these known strategies in ROS‐associated therapy, several fundamental and key principles for the design of ROS‐associated nanomedicines are presented. Finally, future perspectives are also discussed in depth for the development of ROS‐associated nanomedicines.

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Section: Ros‐associated Nanomedicines For Disease Treatmentsmentioning

confidence: 99%

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

et al. 2020

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“…Moreover, natural polymers, such as proteins, polysaccharides, chitosans, gum arabic, and polypeptide polymers are also used for the encapsulation of various antioxidant molecules effectively and exert some competitive advantages in terms of biocompatibility, bioavailability, and biosafety over synthetic polymers (Table 2). However, the synthesis procedure of natural polymeric nanoparticles involves complex steps compared to synthetic one, and may offer an alternative for the preparation of nanocarriers [76]. Furthermore, natural polymers are less commonly used due to their inconsistent purity, and b) the requirement of crosslinking step, which can adversely affect the encapsulated materials [77] and fast release of encapsulated therapeutic agents compared to synthetic polymers.…”

Section: Nanoparticles Mediated Antioxidant Encapsulation and Deliverymentioning

confidence: 99%

“…Moreover, liposomes, spherical vesicles of artificially-prepared phospholipid bilayers, are also being used as antioxidant delivery vehicles (Table 2). Both lipophilic and hydrophilic antioxidants can be loaded into it due to its amphiphilic structure (liposomal bilayer and aqueous core) and are mostly favored for the encapsulation of water insoluble antioxidants, as well as water soluble antioxidants and antioxidants enzymes [76,79]. In this section, we have discussed the nanoparticle aided antioxidant delivery in respect to different nanoparticles/combination of nanoparticles, as well as nanoencapsulation approaches.…”

Section: Nanoparticles Mediated Antioxidant Encapsulation and Deliverymentioning

confidence: 99%

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

et al. 2019

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Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

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“…Some nanomaterials have been found to be able to exhibit enzyme-like antioxidant properties by being capable to scavenge ROS and other free radicals, thereby reducing oxidative injury (Lushchak et al, 2018). Such nanomaterials are generally referred to as "nano-antioxidants" (Watal et al, 2013;Du et al, 2014;Sandhir et al, 2015). Nano-antioxidants include non-organic nanoparticles such as metallic nanoparticles with intrinsic antioxidant properties (Lushchak et al, 2018) as well as nanoparticles functionalized with antioxidant enzymes or natural antioxidants (Sandhir et al, 2015).…”

Section: Nano-antioxidantsmentioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

147

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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Nanocarrier: A potential tool for future antioxidant therapy

Cited by 22 publications

References 69 publications

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

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