Nanocluster-assisted protein-film voltammetry for direct electrochemical signal acquisition

Li, Weihua; Yu, Xiaomei; Huang, Hui

doi:10.1007/s00216-020-03130-5

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…[1][2][3] Hemoglobin (Hb) is a special metalloprotein that is composed of ferroporphyrin as the active center for the redox reactions, metabolic activities, and other biological activities in the human body. [4] Direct electronic communication between Hb and electrode requires suitable conditions for electron transfer. [5] Previous studies have revealed that Hb shows robust adsorption on carbon electrode that does not require the formation of a covalent proteinelectrode surface bond.…”

Section: Introductionmentioning

confidence: 99%

Reduced graphene oxide/titanium carbide MXene nanocomposite‐modified electrode for electrochemical hemoglobin biosensor

Sun

Wang

Ding

et al. 2021

J Chinese Chemical Soc

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In this work, reduced graphene oxide (rGO) and titanium carbide (Ti 3 C 2 T x ) nanocomposite was prepared by the self-assembly method and used for electrode modification. The rGO-Ti 3 C 2 T x nanocomposite was examined by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Then, an electrochemical hemoglobin (Hb) biosensor was prepared on the nanocomposite-modified electrode and used for the determination of trichloroacetic acid (TCA) and hydrogen peroxide (H 2 O 2 ). Direct electrochemistry of Hb on the modified electrode was examined with the calculations of the electron transfer number, electron transfer coefficient, and the reaction rate constant. The presence of the rGO-Ti 3 C 2 T x nanocomposite on the electrode can improve the effective surface area and biocompatibility of the electrode interface, obtaining a higher electron transfer rate. Furthermore, this electrochemical Hb biosensor exhibited excellent stability, reproducibility, and repeatability in TCA and H 2 O 2 analyses.direct electrochemistry, electrocatalysis, electrochemical biosensor, hemoglobin, reduced graphene oxide, Ti 3 C 2 T x

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