Nanocomposite Containing Bioactive Peptides Promote Endothelialisation by Circulating Progenitor Cells: An In vitro Evaluation

Alobaid, Nasser; Salacinski, Henryk J.; Sales, Kevin M.; Ramesh, Bala; Kannan, Ruben Y.; Hamilton, George; Seifalian, Alexander M.

doi:10.1016/j.ejvs.2005.11.034

Cited by 69 publications

(49 citation statements)

References 38 publications

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“…19 It was also observed that POSS-PCU and uncoated culture dishes produced significantly fewer colonies than POSS-PCU-RGD. These results help us to conclude that ECs are capable of morphogenesis and have the ability to proliferate well.…”

mentioning

confidence: 79%

“…When the endothelialization is implemented on the luminal surface of bypass grafts, it improves the lifetime and clinical results of the grafts. 19 The clinical studies done by researchers depict the benefits of lining PTFE vascular grafts with endothelial …”

Section: Nanocomposites To Improve Endothelialization Of Graftmentioning

confidence: 99%

“…In order to circumvent the problems associated with the blood compatibility of bypass grafts, as well as stents and their failure due to lack of mechanical strength and infection, various studies were done incorporating nanocomposites. [17][18][19][20][21][22][23] Despite many studies having been done using nanocomposites for cardiovascular implants, all the works need to be reviewed extensively for the development of a viable heart implant. The prime motive of this review work is to summarize various studies done on nanocomposite cardiovascular applications especially for bypass grafts and stents.…”

Section: Introductionmentioning

confidence: 99%

“…The result of this analysis showed that the quality of cell adhesion and proliferation on POSS-PCU was outstanding. 19 Meanwhile, the qualitative analysis done through scanning electron microscopy (SEM) elucidated the optimum cell-polymer interactions with formation of more filopodia on its surface, flattened ECs, and absence of rounded cells. Flow cytometry results showed that 1%-2% of PBMC (1.5×10 7 ±7×10…”

mentioning

confidence: 99%

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Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Vellayappan¹,

Balaji²,

Subramanian³

et al. 2015

IJN

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Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease.

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mentioning

confidence: 79%

Section: Nanocomposites To Improve Endothelialization Of Graftmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Vellayappan¹,

Balaji²,

Subramanian³

et al. 2015

IJN

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show abstract

“…In particular, the improvement of the endothelialization of the luminal surface of bypass grafts, potentially improve their patency rate and overall clinical outcomes. 48 Studies have shown the clinical benefit of lining polytetrafluoroethylene (PTFE) vascular grafts with endothelial cells, particularly in lower limb arterial bypass grafts, 49 unlike native, uncoated polyethylene terephthalate grafts. In an in-vitro study using human umbilical vein endothelial cells (HUVECs), we assessed whether this nanocomposite is safe and compatible with in vitro cell cultures.…”

Section: Endothelialization Propertymentioning

confidence: 99%

Cardiovascular application of polyhedral oligomeric silsesquioxane nanomaterials: a glimpse into prospective horizons

Ghanbari

Mel²,

Seifalian

2011

IJN

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Revolutionary advances in nanotechnology propose novel materials with superior properties for biomedical application. One of the most promising nanomaterials for biomedical application is polyhedral oligomeric silsesquioxane (POSS), an amazing nanocage consisting of an inner inorganic framework of silicon and oxygen atoms and an outer shell of organic groups. The unique properties of this nanoparticle has led to the development of a wide range of nanostructured copolymers with significantly enhanced properties including improved mechanical, chemical, and physical characteristics. Since POSS nanomaterials are highly biocompatible, biomedical application of POSS nanostructures has been intensely explored. One of the most promising areas of application of POSS nanomaterials is the development of cardiovascular implants. The incorporation of POSS into biocompatible polymers has resulted in advanced nanocomposite materials with improved hemocompatibility, antithrombogenicity, enhanced mechanical and surface properties, calcification resistance, and reduced inflammatory response, which make these materials the material of choice for cardiovascular implants. These highly versatile POSS derivatives have opened new horizons to the field of cardiovascular implant. Currently, application of POSS containing polymers in the development of new generation cardiovascular implants including heart valve prostheses, bypass grafts, and coronary stents is under intensive investigation, with encouraging outcomes.

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Nanocomposite Materials: Polyhedral Silsesquioxanes

Seifalian¹,

Kannan²,

Ghanbari³

et al. 2005

Encyclopedia of Inorganic Chemistry

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The unique properties of nanocomposites have revolutionized the field of materials science. Polyhedral oligomeric silsesquioxane (POSS) is one of the widely used nanostructured materials for the synthesis of hybrid nanocomposites. POSS nanocrystals have been incorporated as building blocks of controllable shapes into polymers to form hybrid materials exhibiting improved properties. A variety of polymerization techniques have been used in the preparation of POSS‐containing hybrids. Incorporation of POSS into polymers can result in substantial improvement in physical properties of the polymers, such as low dielectric constants, increased glass‐transition temperatures, low coefficient of thermal expansion, enhanced thermal stability, mechanical strength, as well as improved oxidation resistance and reduction in flammability, oxygen permeability, heat evolution, and viscosity during processing. The most interesting POSS‐polymer has been the development of POSS–poly(carbonate‐urea)urethane that is used in medical applications owing to its enhanced biocompatibility and antithrombogenesity. These composites are materials of choice in the fabrication of various cardiovascular devices, such as artificial heart valves, stent‐grafts, bypass grafts, microvascular beds, and other biomedical devices including breast implants, and as scaffolds for tissue engineering.

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Nanocomposite Containing Bioactive Peptides Promote Endothelialisation by Circulating Progenitor Cells: An In vitro Evaluation

Abstract: We report a new nanocomposite based biomaterial that has been demonstrated, in vitro, to promote endothelialisation from PBMCs containing EPCs.

Cited by 69 publications

References 38 publications

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Multifaceted prospects of nanocomposites for cardiovascular grafts and stents

Cardiovascular application of polyhedral oligomeric silsesquioxane nanomaterials: a glimpse into prospective horizons

Nanocomposite Materials: Polyhedral Silsesquioxanes

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