Nanoemulsion-based delivery systems for nutraceuticals: Influence of carrier oil type on bioavailability of pterostilbene

High carotenoid bioaccessibility through linseed oil nanoemulsions with enhanced physical and oxidative stability

“…The carrier linseed oil used in the nanoemulsion determined the bioavailability of carotenoids (astaxanthin and lycopene) due to their digestibility and micellization rates. Our results mirror those of Sun et al (2015) for droplet aggregation in the mouth and stomach, but contrast with those in the small intestine phase of linseed oil nanoemulsion encapsulating pterostilbene.…”

“…sions (100 MPa) with the fastest rate of free fatty acid release suggest high lipase saturation attributed to the low water dispersibility of the long chain fatty acids (a-linolenic acid) (McClements & Xiao, 2012). Similar partial digestion (66%) for linseed oil nanoemulsion has been reported (Sun et al, 2015) resulting in low free fatty acid release. The carrier linseed oil used in the nanoemulsion determined the bioavailability of carotenoids (astaxanthin and lycopene) due to their digestibility and micellization rates.…”

“…Nutraceutical, including carotenoid, bioavailability from emulsions depends on the delivery system, carrier oil/emulsifier type and processing, environmental and storage conditions (Sun et al, 2015;Yuan, Gao, Zhao, & Mao, 2008). Therefore, environmental factors (pH, ionic strength, and temperature) encountered during food processing have been evaluated and found to considerably affect b-carotene-enriched nanoemulsion stability (Qian, Decker, Xiao, & McClements, 2012a).…”

Designing emulsion droplets of foods and beverages to enhance delivery of lipophilic bioactive components – a review of recent advances

“…Similar but not identical results were reported for emulsion-based delivery systems containing encapsulated curcumin as a functional ingredient (Ahmed et al, 2012). Sun et al (2015) calculated the percentage of FFAs released from flaxseed and oil olive nanoemulsions using an in vitro digestion model. This effect was attributed to the amount of FFA available to from mixed micelles after the digestion process, in which case the digestion extent followed the order MCT > SCT > LCT.…”

Studies on the curcumin phospholipid complex solidified with Soluplus®

“…Thus, when administered orally, the drug was not directly exposed to the gastrointestinal environment. The delivery system could protect it from chemical degradation during passage throughout gastrointestinal tract . The drug uptake of orally drug is largely influenced by drug solubility and dissolution.…”