Nanoemulsion delivery systems for enhanced efficacy of antimicrobials and essential oils

Garcia, Céline; Malik, Muhammad H.; Biswas, Sujit; Tam, Vincent H.; Rumbaugh, Kendra P.; Li, Wei; Liu, Xinli

doi:10.1039/d1bm01537k

Cited by 51 publications

(22 citation statements)

References 112 publications

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“…CSO can be investigated as a possible candidate for skin diseases based on its profile of high-value chemicals and nutrients. Recently, the NE formulations of various essential oils, such as clove oil, niaouli essential oil, cinnamon oil, lavender oil, and nutmeg oil have been investigated in literature [11,12,[14][15][16][17]. However, the NE formulations of CSO or its biomarker molecules have not been explored in the literature, to the best of the author's knowledge.…”

Section: Introductionmentioning

confidence: 99%

Product Development Studies of Cranberry Seed Oil Nanoemulsion

et al. 2022

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Cranberry seed oil (CSO) can be used in various skin diseases, perhaps due to the presence of ω-3, ω-6, and ω-9 fatty acids. In addition, tocotrienols (vitamin E) has demonstrated powerful antioxidant activity. The combined application of CSO nanoemulsions open a promising avenue for skin conditions. The goal of this work was to create a nanoemulsion (NE) containing CSO and test its stability and in vitro release. To make NE formulations (CNE1-CNE6), the aqueous titration method was used. Following the creation of NE formulations, we selected the CNE4 formulation, which had a mean droplet size of around 110 nm, a narrow size distribution (PDI < 0.2), a steady zeta potential (−34.21 mV), and a high percentage transmittance (>99%). Furthermore, electron microscopy imaging revealed nanosized spherical droplets without any aggregation in the CNE4 formulation, which showed high entrapment efficiency (>80%). Densitometry analysis confirmed linoleic acid (RF 0.62) as a major component of CSO using toluene–acetone–glacial acetic acid (90:9:1 v/v/v) as a mobile phase. Nanogel had a three-fold greater cumulative drug permeation through the skin than neat CSO. This study shows that a unique CSO delivery technique can be used to treat skin diseases.

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Section: Introductionmentioning

confidence: 99%

Product Development Studies of Cranberry Seed Oil Nanoemulsion

et al. 2022

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“…NE have been identified as a promising means of antimicrobial delivery due to their intrinsic antimicrobial properties, ability to increase drug solubility, stability, bioavailability, organ and cellular targeting potentials, capability of targeting biofilms, and potential to overcome antimicrobial resistance. NE can be administered through multiple different routes (oral, parenteral, dermal, transdermal, pulmonary, nasal, ocular, and rectal) [ 123 ].…”

Section: Antimicrobial Nanomedicine Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Antimicrobial Nano-Drug Delivery Systems

et al. 2022

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Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the dissemination of multidrug resistant bacteria. According to a recent report by the World Health Organization, antibacterial (ATB) drug resistance has been one of the biggest challenges, as well as the development of effective long-term ATBs. Since pathogens quickly adapt and evolve through several strategies, regular ATBs usually may result in temporary or noneffective treatments. Therefore, the demand for new therapies methods, such as nano-drug delivery systems (NDDS), has aroused huge interest due to its potentialities to improve the drug bioavailability and targeting efficiency, including liposomes, nanoemulsions, solid lipid nanoparticles, polymeric nanoparticles, metal nanoparticles, and others. Given the relevance of this subject, this review aims to summarize the progress of recent research in antibacterial therapeutic drugs supported by nanobiotechnological tools.

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“…The application of nanoemulsion-based therapeutics has been recently reported in diabetic wound healing approaches. 96 Chakraborty et al synthesized a topical gel formulation made up of homogenized Aloe vera gel incorporated with an insulin-loaded nanoemulsion using oleic acid, polyethylene glycol 400 and Tween 80 to obtain nanodroplet-sized particles. The physicochemical properties of the gel-based formulations indicated good permeation, spreadability and stability.…”

Section: Nanomaterial-based Therapies For Diabetic Foot Ulcersmentioning

confidence: 99%