Nanoenabled Tumor Oxygenation Strategies for Overcoming Hypoxia-Associated Immunosuppression

Zhang, Chao; Yan, Qinglong; Zhu, Ying

doi:10.1021/acsabm.0c01328

Cited by 8 publications

(6 citation statements)

References 140 publications

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“…Unlike PFCs, Hb is chemically reversible to combine with O 2 . [66][67][68] However, free Hb has the disadvantages of poor stability and short blood circulation time, and the Hb tetramer will decompose into dimer and monomer inducing potential toxic and side effects and limiting its O 2 transport into organisms. [11] To reduce the disadvantages of free Hb, researchers modified it through various methods and constructed biocompatible Hb O 2 delivery nanoplatforms.…”

Section: Hemoglobin Direct O 2 Delivery Nanoplatformmentioning

confidence: 99%

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Shen

Chen

Zhao

et al. 2023

Adv Healthcare Materials

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Hypoxia is a typical feature of most solid tumors and has important effects on tumor cells' proliferation, invasion, and metastasis. This is the key factor that leads to poor efficacy of different kinds of therapy including chemotherapy, radiotherapy, photodynamic therapy, etc. In recent years, the construction of hypoxia‐relieving functional nanoplatforms through nanotechnology has become a new strategy to reverse the current situation of tumor microenvironment hypoxia and improve the effectiveness of tumor treatment. Here, the main strategies and recent progress in constructing nanoplatforms are focused on to directly carry oxygen, generate oxygen in situ, inhibit mitochondrial respiration, and enhance blood perfusion to alleviate tumor hypoxia. The advantages and disadvantages of these nanoplatforms are compared. Meanwhile, nanoplatforms based on organic and inorganic substances are also summarized and classified. Through the comprehensive overview, it is hoped that the summary of these nanoplatforms for alleviating hypoxia could provide new enlightenment and prospects for the construction of nanomaterials in this field.

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Section: Hemoglobin Direct O 2 Delivery Nanoplatformmentioning

confidence: 99%

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Shen

Chen

Zhao

et al. 2023

Adv Healthcare Materials

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“…[80] At present, a variety of commonly used treatments, such as chloroquine, recombinant human endostatin (rhES), epidermal growth factor receptor (EGFR) inhibitors, rapamycin, ursolic acid, and anti-vascular endothelial growth factor (VEGF) siRNA, can play a role in many levels to improve tumor blood perfusion and relieve tumor hypoxia. [81][82][83][84] Therefore, the fabrication of a suitable nano platform based on small molecule photosensitizer combined with tumor vascular system normalizers to regulate angiogenesis to alleviate hypoxia and reverse the TIM induced by abnormal tumor blood vessels is of great significance for PDT. [45,85] Given this, Xu et al constructed a new type of drug-loaded SA-PEG-MPDA with indocyanine green (ICG) and PFKFB3 inhibitor (3PO), further modified salicylic acid (SA) on its surface to target E-selectin overexpressed on inflammatory tumor endothelial cells to achieve targeted PDT and photothermal therapy (PTT) based on tumor vascular normalization (Figure 2a).…”

Section: Normalizing Blood Vesselsmentioning

confidence: 99%

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

Yu,

Li,

Wang

et al. 2023

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Photodynamic therapy (PDT) has recently been considered a potential tumor therapy due to its time‐space specificity and non‐invasive advantages. PDT can not only directly kill tumor cells by using cytotoxic reactive oxygen species but also induce an anti‐tumor immune response by causing immunogenic cell death of tumor cells. Although it exhibits a promising prospect in treating tumors, there are still many problems to be solved in its practical application. Tumor hypoxia and immunosuppressive microenvironment seriously affect the efficacy of PDT. The hypoxic and immunosuppressive microenvironment is mainly due to the abnormal vascular matrix around the tumor, its abnormal metabolism, and the influence of various immunosuppressive‐related cells and their expressed molecules. Thus, reprogramming the tumor microenvironment (TME) is of great significance for rejuvenating PDT. This article reviews the latest strategies for rejuvenating PDT, from regulating tumor vascular matrix, interfering with tumor cell metabolism, and reprogramming immunosuppressive related cells and factors to reverse tumor hypoxia and immunosuppressive microenvironment. These strategies provide valuable information for a better understanding of the significance of TME in PDT and also guide the development of the next‐generation multifunctional nanoplatforms for PDT.

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“…It implies the necessity of increasing the supply of oxygen to immune cells to enhance anti-tumor immunity by targeting the OXPHOS complexes and mitochondrial respiration. Nowadays, the supply of oxygen using nanomaterials are getting attention to mitigate the effects of immunosuppressive TME ( 135 ).…”

Section: Therapeutic Prospects Of Targeting Heme and Mitochondrial Re...mentioning

confidence: 99%

The promise of targeting heme and mitochondrial respiration in normalizing tumor microenvironment and potentiating immunotherapy

et al. 2023

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Cancer immunotherapy shows durable treatment responses and therapeutic benefits compared to other cancer treatment modalities, but many cancer patients display primary and acquired resistance to immunotherapeutics. Immunosuppressive tumor microenvironment (TME) is a major barrier to cancer immunotherapy. Notably, cancer cells depend on high mitochondrial bioenergetics accompanied with the supply of heme for their growth, proliferation, progression, and metastasis. This excessive mitochondrial respiration increases tumor cells oxygen consumption, which triggers hypoxia and irregular blood vessels formation in various regions of TME, resulting in an immunosuppressive TME, evasion of anti-tumor immunity, and resistance to immunotherapeutic agents. In this review, we discuss the role of heme, heme catabolism, and mitochondrial respiration on mediating immunosuppressive TME by promoting hypoxia, angiogenesis, and leaky tumor vasculature. Moreover, we discuss the therapeutic prospects of targeting heme and mitochondrial respiration in alleviating tumor hypoxia, normalizing tumor vasculature, and TME to restore anti-tumor immunity and resensitize cancer cells to immunotherapy.

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Nanoenabled Tumor Oxygenation Strategies for Overcoming Hypoxia-Associated Immunosuppression

Cited by 8 publications

References 140 publications

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

The promise of targeting heme and mitochondrial respiration in normalizing tumor microenvironment and potentiating immunotherapy

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