Nanoliposome encapsulated anesthetics for local anesthesia application

Kahroba

Artificial Cells, Nanomedicine, and Biotechnology

et al. 2019

Labour is considered to be one of the most painful procedures in human experience. The most effective technique for pain relief during labour is neuraxial labour analgesia which provides analgesia without maternal or fetal sedation. Genetic predisposition may be of importance for pain perception and women experience varying degrees of pain in labour. Genetic variations in opioid receptor (OPR) genes may influence the response to epidural opioid analgesia during labour. The single-nucleotide polymorphism, A118G of the mu opioid receptor gene (oprm1), has been associated with altered pain perception. Targeted drug delivery reduces toxic side effects. Liposomes, nano-particles, nanofibres hydrogel, have been suggested to deliver anaesthetic drugs.

Section: Nano-carriers For Pain Therapymentioning

confidence: 99%

Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

Kahroba

Artificial Cells, Nanomedicine, and Biotechnology

et al. 2019

“…Nanotechnology-based drug delivery system (DDS) potentially represents such a disruptive technology for the controlled release of an anesthetic drug and reducing systemic toxicity. 8,9 Among various nanocarriers, highly successful results have been recorded for liposomes in pain control and quick patient recovery, such as liposomal bupivacaine in form of DepoFoam bupivacaine. 10,11 Liposomes have superior biocompatibility and favorable pharmacokinetics profile.…”

Section: Introductionmentioning

confidence: 99%

<p>An efficient and long-acting local anesthetic: ropivacaine-loaded lipid-polymer hybrid nanoparticles for the control of pain</p>

Li¹,

Yang²,

Xin³

et al. 2019

IJN

PurposeLocal anesthetics are used clinically for the control of pain following operation (including gastrointestinal surgery) or for the management of other acute and chronic pain. This study aimed to develop a kind of lipid-polymer hybrid nanoparticles (LPNs), which were constructed using poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) as the hydrophilic lipid shell and poly-ε-caprolactone (PCL) as the hydrophobic polymeric core.MethodsRopivacaine (RPV) was entrapped in the LPNs (RPV-LPNs) and the physicochemical and biochemical properties such as size, zeta potential, drug release, and cytotoxicity were studied. The long-lasting effects and safety aspects of the LPNs were evaluated in vitro and in vivo.ResultsThe particle size and zeta potential of RPV-LPNs were 112.3±2.6 nm and −33.2±3.2 mV, with an entrapment efficiency (EE) of 90.2%±3.7%. Ex vivo permeation efficiency of LPNs was better than the drug solution. The RPV-LPNs exhibited a long-lasting in vivo anesthesia effect in both rats and mice.ConclusionConsidering the low cytotoxicity, the LPNs prepared here could be used as an efficient local anesthetic for the control of pain.

Colloids and Surfaces B: Biointerfaces

“…In the last years, among the different types of particulate carriers, liposomes have received a great attention [14] and have been used as delivery systems of different bioactive agents. The list of actives incorporated in nanoliposomes is huge, ranging from pharmaceutical to cosmetics and nutraceuticals substances (opiods, curcumin, resveratrol, quercetin, silibinin, glycyrrhizic acid, vitamin C, and others) [15,16,17,18,19,20,21]. In general, these systems are able to enhance the performance of the incorporated bioactive agents by improving their solubility and bioavailability, their in vitro and in vivo stability, as well as preventing their unwanted interactions with other molecules [22,23].…”

Section: Introductionmentioning

confidence: 99%

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

Pleguezuelos-Villa

Mir-Palomo

Dı́ez-Sales

et al. 2018

The article has 4636 words including ackwonledgment and references. The abstract has 127 words. There are 5 figures and 2 tables. Highlights Nanovesicles were small in size and monodispersed independently of the NA concentration. No citotoxity effects were observed in 3T3 fibroblasts treated with ultradeformable liposomes. Ultradeformable liposomes have the ability to reduce skin inflammation. Graphical abstract AbstractUltradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3, 6 and 9 mg/mL). Nanovesicles were small size (~100 nm), regardless of the NA concentration used, and monodisperse (PI < 0.30). All formulations showed a high entrapment efficiency (~88%) and a highly negative zeta potential (around -30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts.In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (~ 10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher effectiveness of ultradeformable liposomes respect to betamethasone cream and NA dispersion in reducing skin inflammation in mice. Overall, it can conclude that NA ultradeformable liposomes can be considered as a promising formulation for the treatment of skin inflammatory diseases.