Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

Liu, Tengfei; Lü, Yifei; Zhan, Rong; Qian, Wei; Luo, Gaoxing

doi:10.1016/j.addr.2022.114670

Cited by 74 publications

(31 citation statements)

References 257 publications

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“…Hence, researchers, clinicians, engineers, and policymakers should collaborate to overcome the abovementioned challenges of skin tissue engineering scaffolds to promote their practical clinical application. 264…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Designing biomimetic scaffolds for skin tissue engineering

et al. 2023

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Designing biomimetic scaffolds for skin tissue engineering

et al. 2023

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“…As the first physiological barrier of the human body, with the role of protection, excretion, regulation of body temperature, and sensing external stimuli, the skin is in direct contact with the external environment, and it is more susceptible to serious damage. , Wound healing is accomplished by a complex and highly coordinated series of processes in which bacterial infections are especially likely to occur, in particular, infections caused by Staphylococcus aureus (S. aureus), leading to serious complications and prolonged wound healing time. − Therefore, the elimination of bacterial infection is essential for better recovery of wound tissue.…”

Section: Introductionmentioning

confidence: 99%

Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing

Gao

et al. 2023

ACS Appl. Mater. Interfaces

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Bacterial infection and excess reactive oxygen species are key factors that lead to slow or substantially delayed wound healing. It is crucial to design and develop new nanomaterials with antibacterial and antioxidative capabilities for wound healing. Here, positively charged carbon dots (CDs) are rationally designed and synthesized from p-phenylenediamine and polyethyleneimine by a facile one-pot solvothermal method, which show good biocompatibility in in vitro cytotoxicity, hemolysis assays, and in vivo toxicity evaluation. The positively charged CDs show superior antimicrobial effect against Staphylococcus aureus (S. aureus) at very low concentrations, reducing the risk of wound infection. At the same time, CDs with surface defects and unpaired electrons can effectively scavenge excess free radicals to reduce oxidative stress damage, accelerate wound inflammation−proliferation transition, and promote wound healing. The mouse model of skin infection demonstrates that CDs can effectively promote the wound healing of skin infection without obvious side effects by simply dropping or spraying onto the wound. We believe that the prepared CDs have satisfactory biocompatibility, antioxidant capacity, and excellent antibacterial activity and have great application potential in wound healing.

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“…7,8 The integration of the hydrogels with drugs, bioactive factors, cells, and/or specific genes that can accelerate skin regeneration is more simple and convenient. 9 Specially, the injectable in-situ moldable hydrogels that can be directly applied to irregular wounds have received much attention. 10 Although hydrogel-based wound dressings have inherent advantages, there are also some aspects that need to be further improved.…”

Section: Introductionmentioning

confidence: 99%

Construction of injectable collagen-microgel/tannic acid/nano-hydroxyapatite granular hydrogel and evaluation of its potential in wound healing

Bai

Ren

et al. 2023

Journal of Bioactive and Compatible Polymers

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Granular hydrogel is a kind of hydrogel assembled from micro-particles, possessing micro-porous structure that advanced in terms of exudate absorption, mass exchange and cell migration during wound healing. The present study fabricated an injectable granular hydrogel based on tannic acid (TA) connected collagen (COL)-microparticles and hydroxyapatite nanoparticles (nHA). Through the coordination of calcium and phenolic hydroxyl groups, TA was bound on nHA surface to form TA modified nano-hydroxyapatite, TA@nHA. The content of TA bound on nHA surface was as high as 30%. TA@nHA as high as 20% was used as giant crosslinking component to connect COL microgels (COLmg) via hydrogen bond, forming COLmg@TA@nHA granular hydrogel. The size of COL microgels could be controlled via adjusting stirring speed. The larger COL microgels assembled granular hydrogel possessed higher porosity. While the smaller COL microgels assembled granular hydrogel was more stable, showing better self-healing ability in rheological test. Due to the dynamically reversible interactions, COLmg@TA@nHA granular hydrogel was injectable, which could be applied to the skin wound, exhibiting the ability to inhibit inflammatory response, while enhance α-SMA expression, promoting wound healing. The method to fabricate granular hydrogel introduced in this study has a broad scalability toward repairing various tissues.

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Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

Cited by 74 publications

References 257 publications

Designing biomimetic scaffolds for skin tissue engineering

Designing biomimetic scaffolds for skin tissue engineering

Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing

Construction of injectable collagen-microgel/tannic acid/nano-hydroxyapatite granular hydrogel and evaluation of its potential in wound healing

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