Nanomaterials-Based Colorimetric Immunoassays

Liu, Lin; Hao, Yuanqiang; Deng, Dehua; Xia, Ning

doi:10.3390/nano9030316

Cited by 72 publications

(41 citation statements)

References 178 publications

(239 reference statements)

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“…Furthermore, the biosensor was highly selective towards IFN-γ or IL-10 with negligible crossreactivity with each other and similar cytokines (i.e, IL-6). Therefore, this example is an interesting example in term of application of glyconanomaterials which can be extended to other current diagnosis systems based on antibody-methods [16] for the indirect detection of different viruses such as HIV, coronavirus, or even other diseases [25]. A graphene-nitrocellulose ink was printed on a flexible polyimide film (Kapton) in an IDE pattern by aerosolizing graphene and depositing the aerosol mist in highly focused lines.…”

Section: Proteins Immobilized In Nanomaterialsmentioning

confidence: 99%

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Glyconanomaterials for Human Virus Detection and Inhibition

et al. 2021

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Viruses are among the most infectious pathogens, responsible for the highest death toll around the world. Lack of effective clinical drugs for most viral diseases emphasizes the need for speedy and accurate diagnosis at early stages of infection to prevent rapid spread of the pathogens. Glycans are important molecules which are involved in different biological recognition processes, especially in the spread of infection by mediating virus interaction with endothelial cells. Thus, novel strategies based on nanotechnology have been developed for identifying and inhibiting viruses in a fast, selective, and precise way. The nanosized nature of nanomaterials and their exclusive optical, electronic, magnetic, and mechanical features can improve patient care through using sensors with minimal invasiveness and extreme sensitivity. This review provides an overview of the latest advances of functionalized glyconanomaterials, for rapid and selective biosensing detection of molecules as biomarkers or specific glycoproteins and as novel promising antiviral agents for different kinds of serious viruses, such as the Dengue virus, Ebola virus, influenza virus, human immunodeficiency virus (HIV), influenza virus, Zika virus, or coronavirus SARS-CoV-2 (COVID-19).

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Section: Proteins Immobilized In Nanomaterialsmentioning

confidence: 99%

“…Different sections will be focused on proteins, oligosaccharide-functionalized nanomaterials, and glyconanoparticles as biosensors for virus detection and glyconanoconjugates for virus inhibition ( Figure 1 ). Another important kind of virus detection method namely antibody-based was described in a recent review article [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Glyconanomaterials for Human Virus Detection and Inhibition

et al. 2021

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“…), nanozymes offer greater advantages than the conventional artificial enzymes and are potentially being used in the applications of biosensing, immunoassays, therapeutics, in recent times [24]- [26]. Nanozymes-based immunoassays are not only accurate and effective but also more robust even in harsh environments, in comparison to natural and other artificial enzymes [25]. Figure 4 lists, though not extensively, various aspects of typical nanozymes.…”

Section: Nanozymesmentioning

confidence: 99%

“…a. Electrochemical biosensor: These are the most commonly used biosensors and are generally comprised of immobilized enzyme and a transducer, which measure the changes in electronic current, ionic, or conductance on the medium, Various aspects of nanozymes [25], [29].…”

Section: ) Classifications Of Biosensorsmentioning

confidence: 99%

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Pramanik

Solanki

Debnath³

et al. 2020

IEEE Access

122

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Healthcare sector is probably the most benefited from the applications of nanotechnology. The nanotechnology, in the forms of nanomedicine, nanoimplants, nanobiosensors along with the internet of nano things (IoNT), has the potential to bring a revolutionizing advancement in the field of medicine and healthcare services. The primary aim of this paper is to explore the clinical and medical possibilities of these different implementations of nanotechnology. This paper provides a comprehensive overview of nanotechnology, biosensors, nanobiosensors, and IoNT. Furthermore, multilevel taxonomies of nanotechnology, nanoparticles, biosensors, nanobiosensors, and nanozymes are presented. The potential medical and clinical applications of these technologies are discussed in details with several examples. This paper specifically focuses on IoNT and its role in healthcare. In addition to describing a general architecture of IoNT for healthcare, the communication architecture of the IoNT is also explained. The challenges in the successful realization of IoNT are also discussed critically, along with a special discussion on internet of bio-nano things (IoBNT) and its potential in making IoNT more compatible to human body.

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“…Furthermore, some ultrasensitive detection techniques such as digital PCR and single molecule analysis can be combined with nanotechnology to further improve the sensitivity (Cohen and Walt, 2017;Sreejith et al, 2018). Moreover, some nanomaterials such as Fe 3 O 4 , palladium and platinum nanoparticles have very high catalytic activity so they can be directly used as reporters for signal generation (Liu et al, 2019).…”

Section: Remaining Challenges and Future Directionsmentioning

confidence: 99%

Recent Trends in Nanomaterial-Based Biosensors for Point-of-Care Testing

Wang¹,

Guo

2020

Front. Chem.

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In recent years, nanomaterials of different shape, size, and composition have been prepared and characterized, such as gold and silver nanoparticles, quantum dots, mesoporous silica nanoparticles, carbon nanomaterials, and hybrid nanocomposites. Because of their unique physical and chemical properties, these nanomaterials are increasingly used in point-of-care testing (POCT) to improve analytical performance and simplify detection process. They are used either as carriers for immobilizing biorecognition elements, or as labels for signal generation, transduction and amplification. In this commentary, we highlight recent POCT technologies that employ nanotechnology for the analysis of disease biomarkers, including small-molecule metabolites, enzymes, proteins, nucleic acids, cancer cells, and pathogens. Recent advances in lateral flow tests, printable electrochemical biosensors, and microfluidics-based devices are summarized. Existing challenges and future directions are also discussed.

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Nanomaterials-Based Colorimetric Immunoassays

Cited by 72 publications

References 178 publications

Glyconanomaterials for Human Virus Detection and Inhibition

Glyconanomaterials for Human Virus Detection and Inhibition

Advancing Modern Healthcare With Nanotechnology, Nanobiosensors, and Internet of Nano Things: Taxonomies, Applications, Architecture, and Challenges

Recent Trends in Nanomaterial-Based Biosensors for Point-of-Care Testing

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