Nanomedicine-based combination of gambogic acid and retinoic acid chlorochalcone for enhanced anticancer efficacy in osteosarcoma

Лю, Лэй; Qi, Xiaojun; Zhong, Zhaokun; Zhang, En-Ning

doi:10.1016/j.biopha.2016.06.001

Cited by 26 publications

(13 citation statements)

References 18 publications

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“…2) is one of the major compounds derived from gambogethe resin exuded from Garcinia species including G. hanburyi and G. Morella [637]. It has multiple biological activities such as anti-oxidative, anti-inflammatory, and anti-cancer activities [638,639]. Plenty of evidence shows that GA inhibits cell proliferation, invasion, survival, metastasis and chemoresistance, and induces angiogenesis in many types of cancers such as gastric and prostate cancers, leukemia, multiple myeloma, osteosarcoma, and renal carcinoma through multiple signaling mechanisms [640][641][642][643][644][645][646].…”

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

“…This GA-TAT enhances apoptosis through ROS accumulation in human bladder cancer EJ cells. Another study uses a co-polymer to encapsulate GA to form GA micelles [639]. These GA micelles have better cellular uptake which can further enhance apoptosis in human breast cancer MCF-7 cells and the anti-tumor effects in MCF-7 xenograft mice.…”

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

“…The combination of GA and other chemotherapy agents has been widely used to improve the therapeutic effects against various cancers such as osteosarcoma, pancreatic and lung cancers [639,653,663,664]. Cisplatin resistance is a main clinical problem for the treatment of lung cancer, and the treatment of cisplatin with GA is shown to enhance apoptosis and decrease the cisplatin resistance index in human NSCLC cisplatin-resistance A549/ DDP cells [663].…”

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

“…Cisplatin resistance is a main clinical problem for the treatment of lung cancer, and the treatment of cisplatin with GA is shown to enhance apoptosis and decrease the cisplatin resistance index in human NSCLC cisplatin-resistance A549/ DDP cells [663]. Moreover, GA and retinoic acid chlorochalcone are loaded into glycol chitosan nanoparticles to form RGNP [639]. The RGNP exhibits synergistic effects to inhibit cell proliferation and induces apoptosis in osteosarcoma.…”

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

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Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Gambogic Acid (Ga)mentioning

confidence: 99%

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

Section: Gambogic Acid (Ga)mentioning

confidence: 99%

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Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…Recently, nanoparticulate drug delivery system (NDDS), especially ligand-directed targeted NDDS, has been widely studied as a powerful platform for treatment of cancer [10][11][12], and achieved great success. Targeted NDDS loaded with chemotherapeutic drugs could not only reduces the toxic side-effects of chemotherapeutic agents by minimizing non-specific normal tissue accumulation, but also strengthens tumor targeting by enhanced permeation and retention (EPR) effect [13][14][15], and improving affinity between nanoparticles and membranes of treated cells.…”

Section: Introductionmentioning

confidence: 99%

Targeted osteosarcoma chemotherapy using RGD peptide-installed doxorubicin-loaded biodegradable polymeric micelle

Fang

Sun

Xiao

et al. 2017

Biomedicine & Pharmacotherapy

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Green synthesis of metal nanoparticles using Garcinia extracts: a review

2021

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The demand for nanoparticles has been increasing rapidly in recent years due to their unique properties of interest for a wide range of applications. Several physical, chemical, or microorganisms-based methods can be employed in the synthesis of nanoparticles . However, classical processes are time-consuming, complicated, and raise environmental concerns due to the use of high energy and toxic chemicals. Synthesis using plant extract outweighs some classical methods because it is rapid, simple, and eco-friendly. Therefore, plant extract appears promising to produce nanoparticles . Here we review the use of extracts from various species and plant parts of Garcinia for the green synthesis of metal nanoparticles . Garcinia gummi-gutta is a tropical species of Garcinia native to Indonesia. Common names include Garcinia cambogia, as well as brindleberry, Malabar tamarind, Goraka, and kudam puli. The fruit looks like a small pumpkin and is green to pale yellow. We present the major metabolites responsible for metal ions reduction and nanoparticles stabilisation, the synthesis mechanism, the types of metal nanoparticles formed, and their potential applications. Advantages and challenges of Garcinia extract utilisation are also discussed.

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Nanomedicine-based combination of gambogic acid and retinoic acid chlorochalcone for enhanced anticancer efficacy in osteosarcoma

Cited by 26 publications

References 18 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Targeted osteosarcoma chemotherapy using RGD peptide-installed doxorubicin-loaded biodegradable polymeric micelle

Green synthesis of metal nanoparticles using Garcinia extracts: a review

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