Nanonet-nano fiber electrospun mesh of PCL–chitosan for controlled and extended release of diclofenac sodium

Saudi, Sheikh; Bhattarai, Shanta Raj; Adhikari, Udhab; Khanal, Shalil; Sankar, Jagannathan; Aravamudhan, Shyam; Bhattarai, Narayan

doi:10.1039/d0nr05968d

Cited by 41 publications

(22 citation statements)

References 51 publications

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“…Due to this fact, PCL is one of the most used synthetic polymers for medical applications, such as controlled drug delivery or release systems with a single bolus administration [1,2], as well as wound dressing [3,4] or regenerative tissue engineering [5,6]. Release systems, or drug delivery vehicles, have received increased attention in pharmaceutical treatment because they afford several advantages compared to conventional forms of dosage, including enhanced therapeutic efficacy and low toxicity when the drug is released at a controlled rate [7][8][9][10][11]. The release time of the drug needs to be prolonged for days or even several weeks.…”

Section: Introductionmentioning

confidence: 99%

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

et al. 2021

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Diclofenac sodium salt (DSS)-loaded electrospun nanofiber mats on the base of poly(ε-caprolactone) (PCL) were investigated as biocompatible nanofibrous mats for medical applications with the ability to inhibit bacterial infections. The paper presents the characteristics of fibrous mats made by electrospinning and determines the effect of medicament on the fiber morphology, chemical, mechanical and thermal properties, as well as wettability. PCL and DSS-loaded PCL nanofibrous mats were characterized using scanning electron microscopy, transmission electron microscopy, attenuated total reflectance-Fourier transform infrared spectrometry, dynamic mechanical analysis, and contact angle measurements. Electron paramagnetic resonance measurements confirmed the lifetime of DSS before and after application of high voltage during the electrospinning process. In vitro biocompatibility was studied, and it was proved to be of good viability with ~92% of the diploid human cells culture line composed of lung fibroblast (MRC 5) after 48 h of incubation. Moreover, the significant activity of DSS-loaded nanofibers against cancer cells, Ca Ski and HeLa, was established as well. It was shown that 12.5% (m/V) is the minimal concentration for antibacterial activity when more than 99% of Escherichia coli (Gram-negative) and 99% of Staphylococcus aureus (Gram-positive) have been exterminated.

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Section: Introductionmentioning

confidence: 99%

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

et al. 2021

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“…On the contrary, the release rate of ketoprofen revealed no significant difference on pristine and plasma-treated PCL membranes. Diclofenac sodium(DS) combined with an electrospinning nano-and-nanofiber (DS-NNEM) mesh of polycaprolactone (PCL)-chitosan (CH) prepared by the electrospinning technique was the subject of a controlled release study of soluble DS in water [ 13 ]. Because of the very slow degradation of nanofiber mats, these authors suggested that DS is released either by diffusion or by permeation through DS-NNEMs structure.…”

Section: Introductionmentioning

confidence: 99%

Naproxen-Loaded Poly(2-hydroxyalkyl methacrylates): Preparation and Drug Release Dynamics

et al. 2022

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Poly(2-hydroxyethylmethacrylate)/Naproxen (NPX/pHEMA) and poly (2-hydroxypropyl methacrylate)/Naproxen (NPX/pHPMA) composites with different NPX content were prepared in situ by free radical photopolymerization route. The resulted hybrid materials were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning Electron microscopy (SEM), and X-ray diffraction (XRD). These composites have been studied as drug carrier systems, in which a comparison of the in vitro release dynamic of NPX between the two drug carrier systems has been conducted. Different factors affecting the performance of the release dynamic of this drug, such as the amount of Naproxen incorporated in the drug carrier system, the pH of the medium and the degree of swelling, have been investigated. The results of the swelling study of pHEMA and pHPMA in different media pHs revealed that the diffusion of water molecules through both polymer samples obeys the Fickian model. The “in vitro” study of the release dynamic of Naproxen from NPX/pHEMA and NPX/pHPMA drug carrier systems revealed that the higher percentage of NPX released was obtained from each polymer carrier in neutral pH medium, and the diffusion of NPX trough these polymer matrices also obeys the Fickian model. It was also found that the less the mass percent of NPX in the composites, the better its release will be. The comparison between the two drug carrier systems revealed that the pHEMA leads to the best performance in the release dynamic of NPX. Regarding Naproxen solubility in water, the results deducted from the “in vitro” study of NPX/pHEMA10 and NPX/pHPMA10 drug carrier systems revealed a very significant improvement in the solubility of NPX in media pH1 (2.33 times, 1.43 times) and 7 (3.32 times, 2.60 times), respectively, compared to those obtained by direct dissolution of Naproxen powder.

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“…Because of the nanofiber net’s slow degradation, the release was mostly governed by diffusion or permeation. The cell viability and imaging data indicate that NIH 3T3 cells experienced no toxicity in the DLF- nanonets structures [ 32 ]. Most of these studies carried in the near past are based on the release and toxicity study of the DLF loaded polymeric systems.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Antibacterial Efficacy and Biocompatibility of PAN Nanofibers Loaded with Diclofenac Sodium Salt

et al. 2021

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Side effects of the drugs’ oral administration led us to examine the possibility of using diclofenac sodium (DLF) in a polymeric drug delivery system based on electrospun polyacrylonitrile (PAN) nanofibers, which can be produced cost-effectively and with good applicability for transdermal treatments. The inclusion of DLF in PAN nanofibers increased the nanofiber diameter from ~200 nm to ~500 nm. This increase can be attributed to the increase in the spinning solution viscosity. FTIR spectra confirm the entrapment of the DLF into the PAN nanofibers. X-ray diffraction pattern showed that the inclusion of the DLF in the PAN nanofibers had caused the misalignment in the polymeric chains of the PAN, thus resulting in a decrease of the peak intensity at 2θ = 17o. The DLF loaded PAN nanofibers were efficient against the gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli), with maximum inhibition zone of 16 ± 0.46 mm for E. coli and 15.5 ± 0.28 mm for S. aureus. Good cell viability ~95% for L929 cells in more extended incubation periods was reported. A gradual release of DLF from the PAN nanofiber was observed and can be attributed to the stability of Pan in PBS medium. Cell adhesion micrographs show that cell-cell interaction is stronger than the cell-material interaction. This type of weak cell interaction with the wound dressing is particularly advantageous, as this will not disturb the wound surface during the nursing of the wound.

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Nanonet-nano fiber electrospun mesh of PCL–chitosan for controlled and extended release of diclofenac sodium

Abstract: Electrospun nanofiber (EN) technology has been used in the past to generate electrostatically charged multilayer-nanofibers. This platform offers versatile applications including in tissue engineering, drug delivery, wound dressings, and high-efficiency...

Cited by 41 publications

References 51 publications

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

The Drug-Loaded Electrospun Poly(ε-Caprolactone) Mats for Therapeutic Application

Naproxen-Loaded Poly(2-hydroxyalkyl methacrylates): Preparation and Drug Release Dynamics

Evaluating Antibacterial Efficacy and Biocompatibility of PAN Nanofibers Loaded with Diclofenac Sodium Salt

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