Nanoparticle application in diabetes drug delivery

Samavati, Seyedeh Sabereh; Kashanian, Soheila; Derakhshankhah, Hossein; Rabiei, Morteza

doi:10.1007/s11051-022-05547-8

Cited by 10 publications

(5 citation statements)

References 60 publications

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“…Even though PCL can provide an NP for the medication delivery of insulin, different polymers and/or metals may improve this system. Researchers may be able to develop the best insulin DDS by utilising PCL in a stimuli-responsive system because of the strong encapsulation and entrapment performance of PCL nanosystems on insulin 40 .…”

Section: Pcl (Poly-ε-caprolactone) Nanoparticlesmentioning

confidence: 99%

Untitled

2023

IJPSR

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Anti-diabetic medications, like insulin and glucagon-like peptide1(GLP-1) and its analogues are critical for diabetics to maintain blood glucose control. The difficulty of current insulin-based therapies for Type I & II diabetes mellitus, as well as the risks connected with fluctuations in blood glucose levels (hyperglycemia and hypoglycemia), served as the impetus for the establishment of "smart insulin" technology (glucose-responsive insulin; GRI). Insulin-dependent diabetes can be treated with glucose-responsive nanoparticles, a promising technology. The creation of nanoparticles of diverse sizes, features, and compositions allows for a variety of drug-delivery activities. When combined with a glucose measuring unit, this technology can give exogenous insulin more dependably and painlessly than conventional treatment. Nanoparticles made of polymers that are biocompatible and degradable have been created. These nanoparticles shield insulin from oxidation and make it easier for insulin to enter cells via a paracellular or transcellular pathway, whether or not they are linked to the nanoparticles. These techniques can potentially dramatically increase drug administration under controlled conditions, bioavailability, prolonged half-life, and clinical efficacy. The use of recent advancements in polymer chemistry and nanotechnology to a variety of forms and delivery techniques for the efficient and secure administration of insulin for the management of diabetes mellitus will be covered in this review.

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Section: Pcl (Poly-ε-caprolactone) Nanoparticlesmentioning

confidence: 99%

Untitled

2023

IJPSR

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“…5,6 A variety of intelligent hydrogels have been extensively studied in order to explore their potential use as controlled medication delivery systems. 7,8 These smart stimuliresponsive materials vary their volume in response to external factors like pH, 9−12 temperature, 13,14 magnetic field, 15,16 etc. Smart materials have performed well in controlled drug release and site-specific delivery studies.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Hydrogels are a category of polymer networks that exhibit three-dimensional structures and possess hydrophilic properties . These materials have gained significant traction in various domains, including biomedicine and environmental research, due to their versatile uses. − Hydrogels exhibiting distinct responses based on various stimuli, including temperature, pH, light, and electric or magnetic fields, are classified as “smart” hydrogels. , A variety of intelligent hydrogels have been extensively studied in order to explore their potential use as controlled medication delivery systems. , These smart stimuli-responsive materials vary their volume in response to external factors like pH, − temperature, , magnetic field, , etc. Smart materials have performed well in controlled drug release and site-specific delivery studies.…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release

Ganguly,

Das,

Srinivasan

et al. 2024

ACS Appl. Nano Mater.

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Superparamagnetic nanoparticle-arrested hydrogel matrices have immense significance in smart soft biomaterials. Herein, we report the synthesis of superparamagnetic nanoparticle-loaded magneto-responsive tough elastomeric hydrogels for dual-responsive drug delivery. In the first phase of work, we carried out roomtemperature synthesis of amine-functionalized superparamagnetic iron oxide nanoparticles (IONPs), and in the second phase of work, we demonstrated that IONPs could act as a toughening agent as well as a viscosity modifier for poly(acrylic acid-co-hydroxyethyl methacrylate) copolymer hydrogels. The hydrogel was tested by Fourier transformed infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and continuous-wave-electron paramagnetic resonance (CW-EPR). Moreover, the IONPs affect its gelation time and elasticity significantly, which was also evaluated from its rheological behavior. The compressive mechanical strength (∼120 kPa), elasticity, recovery to original shape (zero permanent set), water uptake, and thixotropic behavior under dynamic stress of the hybrid hydrogels have supported its robustness in the swelled state. The drug release behavior of the hydrogel showed dual parameter dependency (IONPs and cross-linker) and dual responsiveness against both pH and static magnetic field. The delayed network rupturing, dualresponsive drug delivery nature, and noncytotoxic behavior against human live cells could promote this hybrid hydrogel as an ideal alternative for the remotely controlled drug delivery vehicle.

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“…Despite these advantages, challenges still persist. 10 For instance, solid lipid nanoparticles frequently encounter obstacles such as drug leakage and suboptimal loading efficiency, a consequence of the limited spatial capacity inherent in their lipid matrix structure. 11 In the case of nanoemulsions, their reduced particle size is often a double-edged sword, leading to a compromised stability.…”

Section: Introductionmentioning

confidence: 99%

“…Formulations based on nanoparticles not only mitigate typical side effects linked with conventional drug release systems but also boost the efficiency of oral drug delivery and gastrointestinal absorption. Despite these advantages, challenges still persist . For instance, solid lipid nanoparticles frequently encounter obstacles such as drug leakage and suboptimal loading efficiency, a consequence of the limited spatial capacity inherent in their lipid matrix structure .…”

Section: Introductionmentioning

confidence: 99%

Morin-Based Nanoparticles for Regulation of Blood Glucose

Hua,

Li,

Chen

et al. 2024

ACS Appl. Mater. Interfaces

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Morin, a naturally occurring bioactive compound shows great potential as an antioxidant, anti-inflammatory agent, and regulator of blood glucose levels. However, its low water solubility, poor lipid solubility, limited bioavailability, and rapid clearance in vivo hinder its application in blood glucose regulation. To address these limitations, we report an enzymatically synthesized nanosized morin particle (MNs) encapsulated in sodium alginate microgels (M@SA). This approach significantly enhances morin's delivery efficiency and therapeutic efficacy in blood glucose regulation. Utilizing horseradish peroxidase, we synthesized MNs averaging 305.7 ± 88.7 nm in size. These MNs were then encapsulated via electrohydrodynamic microdroplet spraying to form M@SA microgels. In vivo studies revealed that M@SA microgels demonstrated prolonged intestinal retention and superior efficacy compared with unmodified morin and MNs alone. Moreover, MNs notably improved glucose uptake in HepG2 cells. Furthermore, M@SA microgels effectively regulated blood glucose, lipid profiles, and oxidative stress in diabetic mice while mitigating liver, kidney, and pancreatic damage and enhancing antiinflammatory responses. Our findings propose a promising strategy for the oral administration of natural compounds for blood glucose regulation, with implications for broader therapeutic applications.

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Nanoparticle application in diabetes drug delivery

Cited by 10 publications

References 60 publications

Untitled

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Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release

Morin-Based Nanoparticles for Regulation of Blood Glucose

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