Nanoparticle-drug conjugates treating bacterial infections

Jelínková, Pavlína; Mazumdar, Aninda; Sur, Vishma Pratap; Kočiová, Silvia; Dolezelikova, Kristyna; Jiménez, Ana María Jiménez; Koudelková, Zuzana; Mishra, Pawan Kumar; Šmerková, Kristýna; Heger, Zbyněk; Vaculovičová, Markéta; Moulick, Amitava; Adam, Vojtěch

doi:10.1016/j.jconrel.2019.06.013

Cited by 83 publications

(37 citation statements)

References 227 publications

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“…Interestingly, biofunctionalized AgNPs reportedly target the microbial efflux pumps by modifying their expression or via complete suppression of activity, thereby displaying precedence over the representative antibiotics vulnerable to the microbial efflux[151]. Loading of antimicrobial peptides (AMPs) on AgNPs through a suitable linker molecule provides nanotherapeutic-systems with excellent potency for targeting MDR microbes[152]. AMPs possess significant clinical benefits such as a broadspectrum potency, prompt inception of bioactivity, and relatively low occurrence of resistance.Still, the natural AMPs are vulnerable to the background environments, such as the presence of proteases, changes in pH in addition to the potential toxicity for oral application and uneconomical production costs.…”

mentioning

confidence: 99%

Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Prasher

Sharma

Mudila

et al. 2020

Colloid and Interface Science Communications

110

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From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated toxicity to the biosystems limits their application. Effective utilization of AgNPs, therefore, requires their surface conjugation with biologically benevolent moieties that enhance the bio-acceptability of silver-based nanosystems, and supplementary functionalities for further extension of their unique applications. The clinical importance of AgNPs was established long ago, but their clinical utilization has been explored only recently with the phenomenon of bio-conjugation. The biomolecule-conjugated AgNPs present operable solutions for tedious clinical complications of the present era, such as multidrug resistance, designing of pharmaceuticals with improved bioavailability, superior drug delivery vehicles and in situ bio imaging of important metabolites that utilize the biomolecule-anchored surface engineered AgNPs. This review epigrammatically discusses some interesting clinical applications of surface conjugated AgNPs with biomolecules such as peptides, nucleic acids, amino acids and antibodies in the current nanopharmaceutical paradigm.

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mentioning

confidence: 99%

Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Prasher

Sharma

Mudila

et al. 2020

Colloid and Interface Science Communications

110

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“…The deposited metal nanoparticles can penetrate the bacterial membrane, allowing better intercalation of the conjugated MDPs within the inner membrane, thus making the MDP-AuNP conjugates more active than the nonconjugated MDP itself. Taking advantage of individual components, several bioconjugates composed of metal nanoparticles and membrane-disruptive peptides/polymers have been developed, and show promising therapeutic efficacy against bacterial infection 177 , 178 , 179 .…”

Section: Multi-drug Combination Therapymentioning

confidence: 99%

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Lin

Chi

Yan

et al. 2021

Acta Pharmaceutica Sinica B

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Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes, in contrast to conventional chemotherapeutic drugs, which act on precise targets such as DNA or specific enzymes. Owing to their rapid action, broad-spectrum activity, and mechanisms of action that potentially hinder the development of resistance, MDPs have been increasingly considered as future therapeutics in the drug-resistant era. Recently, growing experimental evidence has demonstrated that MDPs can also be utilized as adjuvants to enhance the therapeutic effects of other agents. In this review, we evaluate the literature around the broad-spectrum antimicrobial properties and anticancer activity of MDPs, and summarize the current development and mechanisms of MDPs alone or in combination with other agents. Notably, this review highlights recent advances in the design of various MDP-based drug delivery systems that can improve the therapeutic effect of MDPs, minimize side effects, and promote the co-delivery of multiple chemotherapeutics, for more efficient antimicrobial and anticancer therapy.

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“…Despite the availability of several broad-spectrum antimicrobial components, antimicrobial resistance is a worldwide health emergency, and it is an enormous challenge for the effective therapy and remedy of many common infections [3,4]. Resistance to antimicrobial components can be defined as the ability of a disease-causing microorganism to resist the therapeutic effects of drugs [5]. As a result, standard treatments become useless, and contaminations persist and may spread to others.…”

Section: Introductionmentioning

confidence: 99%

Metal and Metal Oxide Nanoparticle as a Novel Antibiotic Carrier for the Direct Delivery of Antibiotics

Kotrange

Najda

Bains

et al. 2021

IJMS

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In addition to the benefits, increasing the constant need for antibiotics has resulted in the development of antibiotic bacterial resistance over time. Antibiotic tolerance mainly evolves in these bacteria through efflux pumps and biofilms. Leading to its modern and profitable uses, emerging nanotechnology is a significant field of research that is considered as the most important scientific breakthrough in recent years. Metal nanoparticles as nanocarriers are currently attracting a lot of interest from scientists, because of their wide range of applications and higher compatibility with bioactive components. As a consequence of their ability to inhibit the growth of bacteria, nanoparticles have been shown to have significant antibacterial, antifungal, antiviral, and antiparasitic efficacy in the battle against antibiotic resistance in microorganisms. As a result, this study covers bacterial tolerance to antibiotics, the antibacterial properties of various metal nanoparticles, their mechanisms, and the use of various metal and metal oxide nanoparticles as novel antibiotic carriers for direct antibiotic delivery.

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Nanoparticle-drug conjugates treating bacterial infections

Cited by 83 publications

References 227 publications

Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Metal and Metal Oxide Nanoparticle as a Novel Antibiotic Carrier for the Direct Delivery of Antibiotics

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