Nanoparticle Location and Material-Dependent Dose Enhancement in X-ray Radiation Therapy

Hossain, Mainul; Su, Ming

doi:10.1021/jp306543q

Cited by 151 publications

(111 citation statements)

References 31 publications

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“…Bismuth is a better candidate for high Z radiosensitiser research since it is one of the heaviest naturally occurring elements of the periodic table [13]. Bismuth oxide and other bismuth-based compounds are also known to be biocompatible [14].…”

Section: Introductionmentioning

confidence: 99%

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

et al. 2016

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This study provides the first proof of the novel application of bismuth oxide as a radiosensitiser. It was shown that on the highly radioresistant 9L gliosarcoma cell line, bismuth oxide nanoparticles sensitise to both kilovoltage (kVp) or megavoltage (MV) X-rays radiation. 9L cells were exposed to a concentration of 50 μg.mL −1 of nanoparticle before irradiation at 125 kVp and 10 MV. Sensitisation enhancement ratios of 1.48 and 1.25 for 125 kVp and 10 MV were obtained in vitro, respectively. The radiation enhancement of the nanoparticles is postulated to be a combination of the high Z nature of the bismuth (Z = 83), and the surface chemistry. Monte Carlo simulations were performed to elucidate the physical interactions between the incident radiation and the nanoparticle. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64

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Section: Introductionmentioning

confidence: 99%

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

et al. 2016

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“…High-Z nanoparticles (NPs) have been shown to improve the effectiveness of dose conformity to tumour tissue in the case of conventional unsegmented kilovoltage X-rays [19][20][21][22][23][24][25][26][27][28][29][30]. The advantages of NPs, besides the primary benefit of enhancing tumour radiosensitivity, often include biocompatibility, permeability to cell membranes due to their nano-scale dimensions, ability to specifically target certain tumours when coated and actively accumulate at tumour sites with leaky vasculature [21,22].…”

Section: Introductionmentioning

confidence: 99%

Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy

et al. 2016

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Microbeam Radiation Therapy (MRT) exploits tumour selectivity and normal tissue sparing with spatially fractionated kilovoltage X-ray microbeams through the dose volume effect. Experimental measurements with Ta 2 O 5 nanoparticles (NPs) in 9L gliosarcoma treated with MRT at the Australian Synchrotron, increased the treatment efficiency. Ta 2 O 5 NPs were observed to form shells around cell nuclei which may be the reason for their efficiency in MRT. In this article, our experimental observation of NP shell formation is the basis of a Geant4 radiation transport study to characterise dose enhancement by Ta 2 O 5 NPs in MRT. Our study showed that NP shells enhance the physical dose depending microbeam energy and their location relative to a single microbeam. For monochromatic microbeam energies below ∼70 keV, NP shells show highly localised dose enhancement due to the short range of associated secondary electrons. Low microbeam energies indicate better targeted treatment by allowing higher microbeam doses to be administered to tumours and better exploit the spatial fractionation related selectivity observed with MRT. For microbeam energies above ∼100 keV, NP shells extend the physical dose enhancement due to longer-range secondary electrons. Again, with NPs selectively internalised, the local effectiveness of MRT is expected to increase in the tumour. Dose enhancement produced by the shell aggregate varied more significantly in the cell population, depending on its location, when compared to a homogeneous NP distribution. These combined simulation and experimental data provide first evidence for optimising MRT through the incorporation of newly observed Ta 2 O 5 NP distributions within 9L cancer cells. Disciplines Engineering | Science and Technology Studies Publication DetailsEngels, E., Corde, S., McKinnon, S., Incerti, S., Konstantinov, K., Rozenfeld, A., Tehei, M., . Optimizing dose enhancement with Ta2O5 nanoparticles for synchrotron microbeam activated radiation therapy. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (12)

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“…Much research has focused on gold nanoparticles, but other types have been used such as titanium particles doped with rare earths (Townley, 2013, Townley et al, 2012b, Townley et al, 2012a, platinum NPs (Hossain and Su, 2012), gadolinium and hafnium oxide NPs (Maggiorella et al, 2012) and quantum dots (Juzenas et al, 2008a). The major constraint in radiotherapy treatments is the damage to normal tissue.…”

Section: Introductionmentioning

confidence: 99%

Investigation of gold nanoparticle radiosensitization mechanisms using a free radical scavenger and protons of different energies

et al. 2014

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Gold nanoparticles (GNPs) have been shown to sensitise cancer cells to X-ray radiation, particularly at kV energies where photoelectric interactions dominate and the high atomic number of gold makes a large difference to X-ray absorption. Protons have a high cross-section for gold at a large range of relevant clinical energies, and so potentially could be used with GNPs for increased therapeutic effect.Here, we investigate the contribution of secondary electron emission to cancer cell radiosensitisation and investigate how this parameter is affected by proton energy and a free radical scavenger. We simulate the emission from a realistic cell phantom containing GNPs after traversal by protons and X-rays with different energies. We find that with a range of proton energies (1 -250 MeV) there is a small increase in secondaries compared to a much larger increase with X-rays. Secondary electrons are known to produce toxic free radicals. Using a cancer cell line in vitro we find that a free radical scavenger has no protective effect on cells containing GNPs irradiated with 3 MeV protons, while it does protect against cells irradiated with X-rays.3

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Nanoparticle Location and Material-Dependent Dose Enhancement in X-ray Radiation Therapy

Cited by 151 publications

References 31 publications

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

Optimizing dose enhancement with Ta 2 O 5 nanoparticles for synchrotron microbeam activated radiation therapy

Investigation of gold nanoparticle radiosensitization mechanisms using a free radical scavenger and protons of different energies

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