Nanoparticle therapeutics: an emerging treatment modality for cancer

Ferritin Decorated PLGA/Paclitaxel Loaded Nanoparticles Endowed with an Enhanced Toxicity Toward MCF-7 Breast Tumor Cells

“…The number of GdDOTAMA loaded in one nanoparticle (ca. 1x10 5 ) is of the same order of those reported for liposomes or other nanoparticles embedded with contrast agents in their interior and not only on their surface 37,38 . Figure 2A 9…”

“…Therefore surface modification and coating of PLGA nanoparticles is the subject of studies aimed at prolonging their circulation lifetime. The most commonly used strategy to obtain stealth nanoparticles is based on the use of PEG and it has led to the development of several products that are currently in clinical use 5 . However, the recent observation of anti-PEG immunological response 6 has motivated a renewed interest towards the research for alternative strategies.…”

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

“…However, the primary consideration as designing any drug delivery system is to control the drug concentration in the therapeutic window, while plummeting side effects and improving patient compliance. This allows useful treatment cycles to be maintained, and at the same time decreases damage to healthy cells and diminishes the recovery period (Peer et al, 2007;Davis, 2008;Lammers et al, 2008;Dinarvand et al, 2011). Poly (lactic-coglycolic acid) (PLGA) is one of the most successfully used biodegradable polymers because its hydrolysis leads to metabolite monomers, lactic acid and glycolic acid.…”

Synthesis of Diagnostic Silicon Nanoparticles for Targeted Delivery of Thiourea to Epidermal Growth Factor Receptor-Expressing Cancer Cells

“…1 Targeted therapeutics on the other hand, by being more selective, can potentially minimize the side effects of these anticancer agents. [2][3] In efforts to develop targeted anticancer drugs, it is essential to consider many different aspects of molecular biology, such as the interactions with cell surface receptors. [4][5] Protein tyrosine kinases (PTKs) have been identified as major contributors in numerous signal transduction pathways within cell membranes and are implicated in cell proliferation.…”