Nanoparticles: A Promising Drug Delivery Approach

Kadian, Renu

doi:10.22159/ajpcr.2017.v11i1.22035

Cited by 21 publications

(24 citation statements)

References 57 publications

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“…• Nanoparticles Nanocarriers, the largest group of the targeting system, have been introduced to increase the bioavailability, selectivity, and tolerability of anticancer drugs. They are characterized by a colloidal structure with a particle size ranging from 10 to 1000 nm [7,17,[21][22][23]. Nanoparticles have been designed to accept drug molecules by dissolving, attaching, encapsulating or by the entrapping process and delivering them directly to the site of action by the passive method [21,24].…”

Section: Types Of Targeting Carriersmentioning

confidence: 99%

The Impact of New Targeting Methods in the Cancer Therapy

2019

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Rapid development has achieved in treating tumor to stop malignant cell growth and metastasis in the past decade. Numerous researches have emerged to increase potency and efficacy with novel methods for drug delivery. The main objective of this literature review was to illustrate the impact of current new targeting methods to other previous delivering systems to select the most appropriate method in cancer therapy. This review first gave a brief summary of cancer structure and highlighted the main roles of targeting systems. Different types of delivering systems have been addressed in this literature review with focusing on the latest carrier derived from malarial protein. The remarkable advantages and main limitations of the later have been also discussed. PubMed and Science Direct were the main search engines that have been used as information sources to prepare this review. Articles related to cancer targeting system, active and passive processes, current nanoparticles, antibody carriers, and current novel cancer carriers were used as sources in this review. Important points from many references published in the last decade (2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) were selected and included. Several targeting methods were introduced to enhance the efficacy and tolerability of the toxic drug by active and passive processes, but there is still no conclusive carrier without certain drawbacks. A combination of targeting methods probably shows the most appropriate choice for increasing selectivity and safety of anticancer drugs via reducing the concentration of carriers used. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

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Section: Types Of Targeting Carriersmentioning

confidence: 99%

The Impact of New Targeting Methods in the Cancer Therapy

2019

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“…Nanoparticles have several advantages such as improvement in the intracellular infiltration, circulation time of the drug, and enhanced hydrophobic solubility [1]. Nanoparticles are usually <100 nm in size.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Stability of Resveratrol-Conjugated Gold Nanoparticles Modified With Polyethylene Glycol

2020

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Objective: Gold nanoparticles (AuNPs) are highly useful for drug delivery, but their application is limited by their stability as they readily aggregate.This issue can be prevented by adding a stabilizing agent such as resveratrol (RSV), which is a polyphenol derived from plants, that is used to preventcancer. Therefore, we propose a novel method to prepare stable RSV-conjugated nanoparticles modified with polyethylene glycol (RSV-AuNP-PEG).Methods: In the first step, the Turkevich method was used to synthesize the AuNPs. Then, PEG was added as stabilizer agent and conjugated with RSV.The synthesized conjugates were characterized using ultraviolet-visible spectrophotometry, Fourier transform infrared spectroscopy, particle sizeanalysis, and high-performance liquid chromatography.Results: The obtained RSV-AuNP-PEG had a particle size of 83.93 nm with a polydispersity index (PDI) of 0.562 and formed a translucent purple-redfluid in solution. The zeta potential was −22.9 mV, and the highest entrapment efficiency was 75.86±0.66%. For comparison, the RSV-AuNP solutionwas purple and turbid, the particle size was 51.97 nm with a PDI of 0.694, and the zeta potential was −24.6 mV. The stability test results showed thatthe storage stability of RSV-AuNP-PEG was better than that of AuNP-RSV. Further, the RSV-AuNP-PEG was shown to be most stable in 2% bovine serumalbumin (BSA) while the AuNP-RSV was most stable in 2% BSA in phosphate-buffered saline pH 7.4.Conclusion: These results show that modification of RSV-conjugated AuNPs with PEG effectively prevents their aggregation in storage, but only incertain mediums.

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“…Nanoparticles have several advantages, such as improvement in the intracellular infiltration, circulation time of the drug, and enhanced hydrophobic solubility [1]. They consist of different biodegradable materials such as natural or synthetic polymers, lipids, or metals [2].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Stability of Resveratrol-Gold Nanoparticle-Polyethylene Glycol-Folic Acid Conjugates

2020

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Objective: Gold nanoparticles (AuNPs) can be used as targeted drug delivery systems, however, AuNPs have high surface energy and easily aggregate,thus negatively impacting nanoparticle stability. Therefore, it is necessary to add a stabilizing agent to AuNPs. To synthesize AuNPs stabilized bypolyethylene glycol conjugated to folic acid (FA), thus creating a model drug (resveratrol [RSV]) carrier that targets FA receptors on cancer cells.Methods: AuNPs were synthesized using the Turkevich method and stabilized by adding FA conjugated to polyethylene glycol (PEG). After RSV wasloaded, the conjugate was physically characterized and subjected to stability tests.Results: The RSV-AuNP had an average particle size of 51.97 nm (polydispersity index [PDI] 0.694, zeta potential – 24.6 mV). The RSV-AuNP-PEG-FAconjugate (RSV-AuNP-PEG-FA) had an average particle size of 195.6 nm (PDI=0.233, zeta potential=−21.1 mV). Stability tests showed that RSV-AuNPPEG-FA was more stable than RSV-AuNP. Furthermore, RSV-AuNP-PEG-FA and RSV-AuNP were more stable in buffer pH 7.4 and bovine serum albumin2% than in buffer pH 4, cysteine 1%, and NaCl 0.9% solutions.Conclusion: PEG-FA conjugates can improve the stability of RSV-loaded AuNP.

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Nanoparticles: A Promising Drug Delivery Approach

Cited by 21 publications

References 57 publications

The Impact of New Targeting Methods in the Cancer Therapy

The Impact of New Targeting Methods in the Cancer Therapy

Synthesis and Stability of Resveratrol-Conjugated Gold Nanoparticles Modified With Polyethylene Glycol

Synthesis and Stability of Resveratrol-Gold Nanoparticle-Polyethylene Glycol-Folic Acid Conjugates

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