Nanoparticles in Wound Healing and Regeneration

Shurygina, I. A.; Шурыгин, М. Г.

doi:10.1007/978-3-319-63790-7_2

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…Unfortunately, many silver nanocomposites having unique antibacterial properties are also toxic to mammalian cells [ 5 , 6 , 7 , 8 , 9 , 10 ]. One of the approaches allowing to reduce the silver nanoparticles (AgNPs) cytotoxicity is green synthesis application [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

NonToxic Silver/Poly-1-Vinyl-1,2,4-Triazole Nanocomposite Materials with Antibacterial Activity

et al. 2020

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Novel silver/poly-1-vinyl-1,2,4-triazole nanocomposite materials—possessing antimicrobial activity against Gram-positive and Gram-negative bacteria—have been synthesized and characterized in the solid state and aqueous solution by complex of modern physical-chemical and biologic methods. TEM-monitoring has revealed the main stages of microbial cell (E. coli) destruction by novel nanocomposite. The concept of direct polarized destruction of microbes by nanosilver proposed by the authors allows the relationship between physicochemical and antimicrobial properties of novel nanocomposites. At the same time, it was shown that the nanocomposite was nontoxic to the fibroblast cell culture. Thus, the synthesized nanocomposite combining antibacterial activity against Gram-positive and Gram-negative bacteria as well as the absence of toxic effects on mammalian cells is a promising material for the development of catheters, coatings for medical devices.

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Section: Introductionmentioning

confidence: 99%

NonToxic Silver/Poly-1-Vinyl-1,2,4-Triazole Nanocomposite Materials with Antibacterial Activity

et al. 2020

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“…Selenium is an important element that plays crucial role in preventing cancer and protecting cells from oxidative damage [ 26 , 27 ]. It has been reported to exhibit not only antibacterial [ 28 – 31 ], but also anti-cancer [ 28 , 32 ] and anti-inflammatory [ 29 , 33 ] properties that make selenium interesting for various applications including oncology [ 28 , 32 ], regenerative medicine [ 34 ] and tissue engineering [ 29 , 30 , 35 – 37 ]. Selenium nanoparticle (SeNPs) decorated TNTs were studied and reported previously for its antibacterial and anti-inflammatory properties [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced antibacterial and anticancer properties of Se-NPs decorated TiO2 nanotube film

2019

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Selenium nanoparticle modified surfaces attract increasing attention in the field of tissue engineering. Selenium exhibits strong anticancer, antibacterial and anti-inflammatory properties and it maintains relatively low off-target cytotoxicity. In our paper, we present the fabrication, characterization and cytocompatibility of titanium oxide (TiO2) nanotube surface decorated with various surface densities of chemically synthesized selenium nanoparticles. To evaluate antibacterial and anti-cancer properties of such nanostructured surface, gram negative bacteria E. coli, cancerous osteoblast like MG-63 cells and non-cancerous fibroblast NIH/3T3 were cultured on designed surfaces. Our results suggested that selenium nanoparticles improved antibacterial properties of titanium dioxide nanotubes and confirmed the anticancer activity towards MG-63 cells, with increasing surface density of nanoparticles. Further, the selenium decorated TiO2 nanotubes suggested deteriorating effect on the cell adhesion and viability of non-cancerous NIH/3T3 cells. Thus, we demonstrated that selenium nanoparticles decorated TiO2 nanotubes synthesized using sodium selenite and glutathione can be used to control bacterial infections and prevent the growth of cancerous cells. However, the higher surface density of nanoparticles adsorbed on the surface was found to be cytotoxic for non-cancerous NIH/3T3 cells and thus it might complicate the integration of biomaterial into the host tissue. Therefore, an optimal surface density of selenium nanoparticles must be found to effectively kill bacteria and cancer cells, while remaining favorable for normal cells.

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“…Recently, researchers have examined the potential of inorganic nanoparticles in various pathological conditions including wound healing . Some of the inorganic metal and metal oxide NPs that have shown excellent therapeutic properties for wound healing include Au, Ag, selenium (Se), terbium (Tb), Cu, zinc oxide (ZnO), titanium dioxide (TiO 2 ), iron oxide (Fe 2 O 3 ), and cerium oxide (CeO 2 ). , In addition, Ag and ZnO NPs have been significantly evaluated as antimicrobial bandages for treating infection sensitive wounds such as burns or diabetic wounds. , Generally, AgNPs accelerate wound healing owing to their neovascularization and anti-inflammatory effects . Furthermore, they have demonstrated reduction in inflammation by modulating cytokine levels and elevating re-epithelialization.…”

Section: Biomaterial-based Approaches For Wound Therapymentioning

confidence: 99%

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Kaur

Narayanan

Garg

et al. 2022

ACS Appl. Bio Mater.

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Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.

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Nanoparticles in Wound Healing and Regeneration

Cited by 14 publications

References 40 publications

NonToxic Silver/Poly-1-Vinyl-1,2,4-Triazole Nanocomposite Materials with Antibacterial Activity

NonToxic Silver/Poly-1-Vinyl-1,2,4-Triazole Nanocomposite Materials with Antibacterial Activity

Enhanced antibacterial and anticancer properties of Se-NPs decorated TiO2 nanotube film

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

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