Nanoparticles: Utility, Immuno-Toxicology and Ethical Issues

Ambwani, Sonu; Tandon, Roopali; Gupta, Abhay; Ambwani, Tanuj Kumar; Chauhan, R.S.

doi:10.5958/0973-9149.2015.00010.6

Cited by 6 publications

(8 citation statements)

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“…Pyrethroids damage the immune system. [ 13,14 ] Immunotoxicity is characterized by increased oxidative stress, [ 15 ] deficiency in granulocyte differentiation [ 16 ] , and myelotoxicity. [ 17 ] The respiratory system toxicity caused by pyrethroids is effected by impairment in the nociceptor functioning.…”

Section: Introductionmentioning

confidence: 99%

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Ravula

Yenugu

2020

J Biochem & Molecular Tox

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Humans are exposed to pyrethroid‐based pesticides through agricultural produce. In this study, male Wistar rats were orally treated for 9 to 12 months with a mixture of pyrethroids that is equivalent to one‐fifth (high dose; HD) or one‐twenty fifth (low dose; LD) of the amount of pyrethroids present in the cereals and rice consumed by an average Indian. In rats treated for 9 months, the spermatogenesis‐associated genes Abp, Ar, Cd9, Dax1, Dazap1, Ddx3y, Gdnf, Gfra1, Grth, Inhb, Ovol1, P1, Plzf, Pygo2, Scf, Tgfb1, Tp1, Tp2, and Vim1 were downregulated in both LD and HD groups. In rats treated for 12 months Gdnf, Hsf2, Inhb, Tgfb1, Thy1, and Ybx2 expression was downregulated in both LD and HD groups. Steroidogenesis‐associated genes 17‐β‐Hsd, Gata4, Hmgcr, Hmgcs1, Pde4b, and Tspo gene expression were reduced in both LD‐ and HD‐treated groups treated for 9 months. In 12‐month‐treated rats, Creb1 expression decreased in both LD and HD groups. The epigenetic reprogramming‐associated genes, Dnmt1, Dnmt3a, Dnmt3b, Hdac10, Hp1bp3, Kat3a Kat3b, Mch2ta, Ncoa7, and Sirt1 were downregulated in both HD and LD groups of 9‐months‐treated rats. In rats treated for 12 months, Hdac10, Mch2ta, Ncoa7, and Sirt1 messenger RNA levels decreased in both the HD and LD groups. Thus, we demonstrate that long‐term exposure to a mixture of pyrethroids caused aberrations in the transcriptome of factors involved in sperm production and development.

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Section: Introductionmentioning

confidence: 99%

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Ravula

Yenugu

2020

J Biochem & Molecular Tox

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“…Metal nanoparticles-including quantum dots, metal oxide nanoparticles, and pure metal nanoparticles-are considered useful in various biomedical applications (Bonifacio et al 2014;Sharma and Singh 2014;Ambwani et al 2015). Many researchers have put forward various methods for green synthesis of metal nanoparticles, employing microorganisms and plant extracts, that have been found to be eco-friendly, economical, and nontoxic (Makarov et al 2014;Prasad et al 2018).…”

Section: Herbonanoceuticalsmentioning

confidence: 99%

“…However, their potential side effects in patients and the environment are yet to be thoroughly explored (Krug and Wick 2011). Contradictory biosafety considerations pertaining to metal nanoparticles have been reported in different studies (Tsoi et al 2012;Edmundson et al 2014;Ambwani et al 2015).…”

Section: Herbonanoceuticalsmentioning

confidence: 99%

Herbonanoceuticals: A Novel Beginning in Drug Discovery and Therapeutics

Saini

Thakur

Kaur

et al. 2019

Nanobiotechnology in Bioformulations

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“…However, further in vivo studies should be conducted to confirm the actual efficacy of herbal NPs based drugs (Rao et al, 2016). MNPs included quantum dots, metal oxides and pure metal NPs that are said to be useful in various biomedical applications (Bonifácio et al, 2014;Sharma & Singh, 2014;Ambwani et al, 2015). Many researchers have put forward various methods for green synthesis of MNPs employing microorganisms and plant extracts that are found to be ecofriendly, economical and non-toxic (Makarov et al, 2014).…”

Section: Metal Nanoparticles Based Drug Deliverymentioning

confidence: 99%

“…However, their potential side effects in the patients and environment are yet to be thoroughly explored (Krug & Wick, 2011). Contradictory biosafety considerations are reported pertaining to MNPs in different studies (Tsoi et al, 2012;Edmundson et al, 2014;Ambwani et al, 2015).…”

Section: Metal Nanoparticles Based Drug Deliverymentioning

confidence: 99%

Current Knowledge on Nanodelivery Systems and Their Beneficial Applications in Enhancing the Efficacy of Herbal Drugs

Ambwani¹,

Tandon²,

Ambwani³

et al. 2018

JEBAS

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Herbal remedies have been extensively used since times immemorial throughout the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Commonly, the herbal medicines are available in the form of crude extracts prepared in different solvent systems which might not only need large dose administration but also could be less effective in the form of conventional formulations. Moreover, available phytoformulations do not have the ability for specific tissue target delivery in case of different chronic diseases. Oral administration of these herbal formulations is subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption and bioavailability. With the advancements in biotechnology, genomics, and combinatorial chemistry, new, more potent and specific drug delivery systems have been envisaged during the last few decades. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using -Nano Delivery Systems‖ (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient's compliance. Nano herbal medicines can be used to target them to the specific site in the body which improves their selectivity, solubility, delivery, safety, effectiveness and thus reduces the need for

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Nanoparticles: Utility, Immuno-Toxicology and Ethical Issues

Cited by 6 publications

References 0 publications

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Herbonanoceuticals: A Novel Beginning in Drug Discovery and Therapeutics

Current Knowledge on Nanodelivery Systems and Their Beneficial Applications in Enhancing the Efficacy of Herbal Drugs

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