Nanoparticulate molecularly imprinted poly(acrylic acid) as potential stationary phase for chiral separation of ofloxacin

Chakraborty, Soma; Razonabe, Cheem Conanan; Chua, Modesto Tan

doi:10.1504/ijnbm.2014.066901

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Cited by 3 publications

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“…Therefore, effective, simple, and rapid resolution methods need to be developed. Magnetic molecularly imprinted polymers (MMIPs) could represent a solution to this problem [11][12]. MMIPs are generated by combining magnetic materials with molecularly imprinted polymers (MIPs) [13][14].…”

Section: Introductionmentioning

confidence: 99%

Using chiral magnetic surface molecularly imprinted polymers for chiral separation of Ofloxacin

Zhao

Meng

2021

J Polym Res

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Section: Introductionmentioning

confidence: 99%

Using chiral magnetic surface molecularly imprinted polymers for chiral separation of Ofloxacin

Zhao

Meng

2021

J Polym Res

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Molecularly imprinted nanoparticles grafted to porous silica as chiral selectors in liquid chromatography

Gutiérrez-Climente

Gómez‐Caballero

Guerreiro

et al. 2017

Journal of Chromatography A

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Using Chiral Magnetic Surface Molecularly Imprinted Polymers for Chiral Separation of Ofloxacin

Zhao

Yang

2020

Preprint

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BackgroundOfloxacin is an important drug with anti-bacterial effects, and (–)-ofloxacin has been shown to have better anti-bacterial activity than racemic ofloxacin. But chiral resolution of compounds is a major challenge worldwide. Many methods do not show high specificity to target molecules, causing errors in the separation of these pharmaceutical molecules, thus affecting the purity of drugs.MethodThe paper mainly research on a method for quick resolution of ofloxacin using chiral magnetic surface molecular imprinting polymers (chiral MMIP). Fe3O4 magnetic nanoparticles coated with silica is acted as the substrate. Chiral reagent is N-octyl-D-glucosamine as monomer, with ofloxacin as the template molecules to prepare magnetic surface molecularly imprinted polymer. The chiral polymer can be combined with (+)-ofloxacin, eventually (-)-ofloxacin was isolated. ResultsFinally by using extermal magnetic field and transmission electron microscopy (TEM), the character of magnetic surface molecularly imprinted polymer is tested, and The product was tested by ultraviolet spectrum and optical rotation tests and was confirmed to be (-)-ofloxacin. ConclusionA simple, rapid, and cost-effective method for separating chiral compounds was established.

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Nanoparticulate molecularly imprinted poly(acrylic acid) as potential stationary phase for chiral separation of ofloxacin

Cited by 3 publications

References 18 publications

Using chiral magnetic surface molecularly imprinted polymers for chiral separation of Ofloxacin

Using chiral magnetic surface molecularly imprinted polymers for chiral separation of Ofloxacin

Molecularly imprinted nanoparticles grafted to porous silica as chiral selectors in liquid chromatography

Using Chiral Magnetic Surface Molecularly Imprinted Polymers for Chiral Separation of Ofloxacin

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