Nanophotonic trapping for precise manipulation of biomolecular arrays

Soltani, Mohammad; Lin, Jun; Forties, Robert A.; Inman, James T.; Saraf, Summer N.; Fulbright, Robert M.; Lipson, Michal; Wang, Michelle D.

doi:10.1038/nnano.2014.79

Cited by 147 publications

(135 citation statements)

References 34 publications

Supporting

Mentioning

132

Contrasting

Order By: Relevance

“…One feasible approach is to improve the detectors with lower noise and higher pixels, and another is to combine the sensing technique with other methods such as the integrating detector with nanofluidics. [148] As for the efficiency problem, a recent report pointed out that chiral graphene quantum dots were promising for drug delivery to achieve more efficient and selective phototherapies. [149] In the future study, advanced characterization methods are needed for deeper nature.…”

Section: Discussionmentioning

confidence: 99%

Plasmonic Chiral Nanostructures: Chiroptical Effects and Applications

Luo

Chi

Jiang

et al. 2017

Advanced Optical Materials

170

122

View full text Add to dashboard Cite

(circular birefringence) and absorption losses (circular dichroism) with the circu larly polarized light (CPL) illumination. [10] CB arises from the difference in the real part of refractive index, leading to a dif ferent velocity for LCP and RCP compo nents, and thus results in the polarization rotation of the linearly polarized incident light. CD corresponds to the difference in the imaginary part of refractive index, resulting in a distinct absorption loss for LCP and RCP excitations. Besides the con ventional CD and CB, asymmetric trans mission (circular conversion dichroism) is another fundamental chiroptical pheno menon, which exists in the nondiffracting array, referring to different LCPtoRCP and RCPtoLCP conversion efficiencies. [11] All of these chiroptical phenomena have been successfully applied in the spectros copy for identifying special arrangements of chiral matters in biology, chemistry and physics as efficient diagnostic tools. [12][13][14][15][16] However, the chirop tical response in natural chiral materials is relatively weak due to the small electromagnetic (EM) interaction volume, [17] hence limits its further applications.Recent progress in plasmonics paves the way for the enhancement of chiroptical response. [18][19][20] Surface plasmons (SPs), as the collective electrons oscillation at the dielectric and metal interface, [21][22][23] present the capacity of light confine ment and field enhancement, which significantly improve the strength of lightmatter interactions. [24][25][26][27][28] With the uptodate nanofabrication technology, the study field of chirality has been extended from traditional chiral molecules to 3D metallic nanostructures. [29][30][31][32] Chiroptical responses of metallic meta molecules have been widely investigated, [33][34][35] and applied in various fields, such as biosensing, [36] chiral catalysis, [37] polari zation tuning, [38] and chiral photo detection.[39] The 3D metallic structure exhibited giant optical activity response because of the strong interaction between electric and magnetic resonant modes. [40,41] Different from 3D chiral ensembles, planar chiral structures show none chiral effect, as they can always coincide with their mirror images. However, 2D chirality was successfully found in the quasitwodimensional (quasi2D) chiral structure. [42] Moreover, recent reports show that even achiral nanomaterials have the ability to generate strong CD under an oblique CPL illumination. [43] This kind of extrinsic chirality arises from sym metry breaking of the incident light and the quasi2D material, which is quite different from the intrinsic chirality of 3D chiral The plasmonic chiroptical effect has been used to manipulate chiral states of light, where the strong field enhancement and light localization in metallic nanostructures can amplify the chiroptical response. Moreover, in metamaterials, the chiroptical effect leads to circular dichroism (CD), circular birefringence (CB), and asymmetric transmission. Potential applications enabled by chiral plasmonics...

show abstract

Section: Discussionmentioning

confidence: 99%

Plasmonic Chiral Nanostructures: Chiroptical Effects and Applications

Luo

Chi

Jiang

et al. 2017

Advanced Optical Materials

170

122

View full text Add to dashboard Cite

show abstract

“…35 Our results confirm the high values of optical force generated by the cavity. The trapping efficiency is typically described by the optical stability S and the optical stiffness k. The stability is defined as S = U/k B T c , where dr)) is the potential energy that corresponds to the work required to bring the nanoparticle from a free position to the trapping site, k B is the Boltzmann constant, and T c is the temperature expressed in K. 36 The requirement for a stable trapping condition is S > 10, which ensures that the potential energy U is significantly higher than the thermal energy k B T c , such that the trapping force is strong enough to completely overcome the Brownian motion of the particle. 20,37 This condition also highlights the need for high values of U with low input power, in order to keep the temperature low and not to affect the trapping efficiency by adding Brownian motion.…”

Section: Hybrid Cavity Tweezer Performancementioning

confidence: 99%

Ultra-high Q/V hybrid cavity for strong light-matter interaction

Conteduca¹,

Reardon²,

Scullion³

et al. 2017

APL Photonics

View full text Add to dashboard Cite

COLLECTIONS This paper was selected as Featured ARTICLES YOU MAY BE INTERESTED INThe ability to confine light at the nanoscale continues to excite the research community, with the ratio between quality factor Q and volume V, i.e., the Q/V ratio, being the key figure of merit. In order to achieve strong light-matter interaction, however, it is important to confine a lot of energy in the resonant cavity mode. Here, we demonstrate a novel cavity design that combines a photonic crystal nanobeam cavity with a plasmonic bowtie antenna. The nanobeam cavity is optimised for a good match with the antenna and provides a Q of 1700 and a transmission of 90%. Combined with the bowtie, the hybrid photonic-plasmonic cavity achieves a Q of 800 and a transmission of 20%, both of which remarkable achievements for a hybrid cavity. The ultra-high Q/V of the hybrid cavity is of order of 10 6 (λ/n) 3 , which is comparable to the state-of-the-art of photonic resonant cavities. Based on the high Q/V and the high transmission, we demonstrate the strong efficiency of the hybrid cavity as a nanotweezer for optical trapping. We show that a stable trapping condition can be achieved for a single 200 nm Au bead for a duration of several minutes (t trap > 5 min) and with very low optical power (P in = 190 µW).

show abstract

“…12,30,36 However, while the nSWAT resolution is on par with traditional highend optical tweezers, the nSWAT platform is inherently more noise-resistant than free space platforms due to the short optical path difference between the two counter-propagating trapping waves generated on chip. 26 Fig. 4a shows the measured positions of an array of beads in an nSWAT over time, demonstrating that an entire bead array can be stably trapped with minimal drift.…”

mentioning

confidence: 96%

“…29,30 This speed is crucial for transport of an array of trapped beads over a long distance where the microheater's voltage must be rapidly reset to zero each time the trap array is transported by one spatial period λ z of the standing-wave trapping potential before re-ramping the voltage. 26 Such a method requires a precise knowledge of λ z , which may differ somewhat from device to device. Here, we demonstrate a new method of phase tuning and its application in a constant speed mode.…”

mentioning

confidence: 99%

Biocompatible and High Stiffness Nanophotonic Trap Array for Precise and Versatile Manipulation

Badman

Inman

et al. 2017

Biophysical Journal

Self Cite

View full text Add to dashboard Cite

The advent of nanophotonic evanescent field trapping and transport platforms has permitted increasingly complex single molecule and single cell studies on-chip. Here, we present the next generation of nanophotonic Standing Wave Array Traps (nSWATs) representing a streamlined CMOS fabrication process and compact biocompatible design. These devices utilize silicon nitride (Si 3 N 4 ) waveguides, operate with a bio-friendly 1064 nm laser, allow for several watts of input power with minimal absorption and heating, and are protected by an anticorrosive layer for sustained on-chip microelectronics in aqueous salt buffers. In addition, due to Si 3 N 4 's negligible nonlinear effects, these devices can generate high stiffness traps while resolving sub-nanometer displacements for each trapped particle. In contrast to traditional table-top counterparts, the stiffness of each trap in an nSWAT device scales linearly with input power and is independent of the number of trapping centers. Through a unique integration of micro-circuitry and photonics, the nSWAT can robustly trap, and controllably position, a large number of nanoparticles along the waveguide surface, operating in an all-optical, constant-force mode without need for active feedback. By reducing device fabrication cost, minimizing trapping laser specimen heating, increasing trapping force, and implementing commonly used trapping techniques, this new generation of nSWATs significantly advances the development of a high performance, low cost optical tweezers array laboratory on-chip. Graphical Abstract Author ContributionsThe manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. F.Y. and R.B. designed and fabricated the devices. J.T.I., F.Y., and J.L.K. upgraded the nanophotonics measurement setup and F.Y. carried out measurements. M.S. obtained some preliminary data on some of the experiments. F.Y., R.B, and M.D.W. drafted the manuscript and all authors edited the manuscript. M.D.W. provided overall guidance on experimental designs and measurements.Supporting Information. Fabrication protocol for Si 3 N 4 nSWAT device, Data acquisition and analysis methods, Si 3 N 4 waveguide loss measurement, microheater calibration curve, modulation speed measurement of the Ni microheater, 3D full-wave electromagnetic simulations, kymograph of long range transport of trapped bead array, stiffness measurements using three different methods, spatial resolution measurement of trap movement, cross-talk among different traps, and simultaneous trap stiffness calibration for an array of trapped beads. This material is available free of charge via the Internet at http://pubs.acs.org. Optical trapping utilizes the gradient forces of an electromagnetic field to trap and manipulate small dielectric particles. 1-9 A traditional free-space optical trap is a sensitive tool generated by a tightly focused laser beam using table-top optics. These traps can generate piconewtons (pN) of force and detect nanomete...

show abstract

Nanophotonic trapping for precise manipulation of biomolecular arrays

Cited by 147 publications

References 34 publications

Plasmonic Chiral Nanostructures: Chiroptical Effects and Applications

Plasmonic Chiral Nanostructures: Chiroptical Effects and Applications

Ultra-high Q/V hybrid cavity for strong light-matter interaction

Biocompatible and High Stiffness Nanophotonic Trap Array for Precise and Versatile Manipulation

Contact Info

Product

Resources

About