Nanostructured pH-responsive biocompatible chitosan coated copper oxide nanoparticles: A polymeric smart intracellular delivery system for doxorubicin in breast cancer cells

Biosynthesis, characterization of PLGA coated folate-mediated multiple drug loaded copper oxide (CuO) nanoparticles and it’s cytotoxicity on nasopharyngeal cancer cell lines

“…The PLGA-CuO NPs synthesized with 0.5%, 1% and 2% PLGA concentrations were termed as C-1, C-2, C-3 respectively, and the NPs were obtained by the mechanism of freeze-drying. The procedure was adapted with finer modification from Kannan et al (Varukattu et al 2020 ) and (Vivek et al 2014 ). Following this, 4.5 mg of folic acid was mixed in 5 mL of dimethyl sulphoxide (DMSO).…”

“…Anticancer drugs docetaxel and doxorubicin which are sparingly water soluble were loaded inside the FOL-PLGA-CuO NPs (C-1, C-2, C-3) respectively. The procedure was adapted from Kannan et al (Varukattu et al 2020 ) with definite modifications. 5 mg of freeze-dried C-1, C-2 and C-3 were added to 25 mL of Milli-Q water and by addition of 1 mL of doxorubicin and docetaxel mixture (concentration of drug was taken as 1 mg/mL each) within the resultant solution.…”

“…After incubation of 3–4 min, visualization of cells was done using a Nikon made fluorescence microscope with an excitation filter of 510–590 nm. The procedure was adapted from Kannan (Varukattu et al 2020 ) and Vivek et al ( 2014 ).…”

Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

“…Chitosan nanofibers have recently exhibited controlled drug release affinity [169]. This material may be useful for the delivery of proteins/peptides, anti-inflammatory drugs, antibiotics, imaging agents.…”

Copper Nanoparticles: A Review on Synthesis, Characterization and Applications

“…Nanoparticles provide site specific drug delivering system, due to its small size, large absorptive surface for drug to carry and also shows improved therapeutic efficacy with less toxicity. Brest Cancer was targeted using chitosan coated copper nanoparticles at different pH for drug doxorubicin, on MCF-7 cell line by studying apoptotic activity of cells [101]. Antimicrobial activity using biopolymer chitosan micro particles conjugated with copper NPs which shows greater synergic effect for antibacterial activity of tetracycline against Gram positive and Gram Negative bacteria [102] also core-shell Nano carriers were used to enhance activity of tetracycline, where copper oxide NPs was used as core and hyper-branched polyglycerol as shell [103].…”