Nanosuspension: Potential Applications of Nano Therapeutics in Ocular Delivery

Abstract

Nanotechnology involves creating and using the materials, devices or systems on the nanometer scale respectively. Nanotechnology is the science that deals with the process that occurs at molecular level and of nano length scale size. Nano refers to the particle size range of 1-1000nm. Nanosuspensions are coming under nanotechnology. The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. In the past two decades, ocular drug delivery research accelerated advanced towards developing a novel, safe and patient compliant formulation and drug delivery devices/techniques, which may surpass these barriers and maintain drug levels in tissues. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topical drops. The particle size influences its functionality in terms of its uptake, residence in circulation, adherence, degradation, clearance. This review article describes considerations of nanosuspension for ocular delivery, ocular barriers, strategies to overcome blood ocular barriers, ocular drug-delivery mechanisms, ocular pharmacotherapy, conventional pharmacotherapy of ocular diseases, and applications of nanosuspensions in ocular delivery.