Nanotechnology for neurodegenerative disorders

Polyelectrolyte-coated nanocapsules containing undecylenic acid: Synthesis, biocompatibility and neuroprotective properties

“…A successful prevention and an effective treatment of the central nervous system disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis represent a major challenge of contemporary medicine [1]. The course of these diseases is also a considerable social problem, affecting not only patients but their whole families [2].…”

Solid lipid nanoparticles loaded with lipoyl–memantine codrug: Preparation and characterization

“…It has been reported that the benefit-risk balance deriving from the use of NPs for the treatment of CNS diseases should be carefully evaluated for each type of new engineered NP intended for brainspecific drug delivery (Re et al, 2012). In this study, the results of our cytotoxicity assays (MTT and LDH) showed that even 100 mM of SLNs alone did not cause any significant changes in cell viability and oxidative status.…”

Neuroprotective Investigation of Chitosan Nanoparticles for Dopamine Delivery

“…Recently, nanotechnology has been shown to be able to provide valuable tools for potentially diagnosing and treating diseases in many fields of medicine, including NDs [4][5][6][7][8][9][10]. Furthermore, NPs can help to overcome several limitations of traditional drugs by improving their bioavailability and half-life, yielding a sustained release, in addition to allowing specific targeting [11][12][13].…”