Nanotechnology in Dental Therapy and Oral Tissue Regeneration

Yang, Zukun; Han, Lu; Yu, Guoqing; Liang, Jia; Yin, C. Cameron; Xia, Yang

doi:10.1007/978-981-15-5386-8_3

Cited by 8 publications

(3 citation statements)

References 331 publications

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“…Moreover, some of the mentioned cleansing methods can also damage the soft denture liners and cause more microbial plaque accumulation [ 11 , 12 ]. Several researchers have already incorporated a variety of medicament including antifungal drugs, metal oxides, and herbs into the soft denture liners, as a reliable method to overcome denture-induced stomatitis [ 13 , 14 ]. Although many of these modified soft denture liners showed promising results against microorganisms, different shortcomings were also reported for the investigated additives.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial and Antibiofilm Activities of Copper Oxide Nanoparticles within Soft Denture Liners against Oral Pathogens

Ansarifard

Zareshahrabadi

Sarafraz

et al. 2021

Bioinorganic Chemistry and Applications

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Objectives. Soft denture liners provide a favorable environment for adhesion and colonization of microorganisms. This in vitro study aimed to examine the efficacy of different concentrations of copper oxide nanoparticles (CuO NPs) incorporation into soft denture liner on the biofilm formation of the microbial species. Methods. Field Emission Scanning Electron Microscopy (FESEM) images from NPs were recorded. Antifungal susceptibility testing of CuO NPs against five standard strains of Candida albicans (CBS 10261, 1905, 1912, 1949, 2730), Streptococcus mutans (ATCC35668), Streptococcus sobrinus (ATCC27607), and Streptococcus salivarius (ATCC9222) was performed by the broth microdilution method with the Clinical and Laboratory Standards Institute reference method. The biofilm inhibition percentages of CuO NPs on the soft denture liners were determined by XTT assay. Results. The characterization of CuO NPs by scanning electron microscope (SEM) analyses confirmed the synthesis of NPs with appropriate structure and size with a mean diameter of 18.3 ± 9.1 nm. The CuO NPs successfully inhibited the growth of the tested standard strains of C. albicans and Streptococcus spp. at concentrations ranging from 64 to 128 µg mL−1. Indeed, incorporation of CuO NPs at a concentration of 500 µg mL−1 into the soft denture liners exhibited a significant activity (75%) in inhibition of C. albicans. biofilm formation in a dose-dependent manner. The biofilm formation of C. albicans in the presence of CuO NPs was lower than Streptococcus spp. in comparison with the control group ( p < 0.05 ). Conclusion. Incorporation of CuO NPs significantly decreased the colonization and plaque formation of the oral pathogens, especially C. albicans accumulation. These NPs may be useful as a promising agent for the antimicrobial management of soft denture liner materials.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial and Antibiofilm Activities of Copper Oxide Nanoparticles within Soft Denture Liners against Oral Pathogens

Ansarifard

Zareshahrabadi

Sarafraz

et al. 2021

Bioinorganic Chemistry and Applications

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“…The therapy aims to stabilize, reorganize the gingival tissue, periodontal fibers, and alveolar bone (Yang et al, 2020). The treatment of tooth mobility in periodontal disease is determined by the degree of damage to the bone supports.…”

Section: Introductionmentioning

confidence: 99%

The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model

Lestari¹,

Darwin²,

Putra³

et al. 2021

J Pharm Pharmacogn Res

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Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones. The α-mangostin has shown role-playing in the bone remodeling process. Aims: To evaluate the potential of α-mangostin induce the TGFβ1 titer associated with the increased mandibular bone volume on the alveolar bone remodeling of periodontitis of Rattus novergicus. Methods: The α-mangostin used to the single administration dosage on the rat periodontitis model on the 7 and 14 days. TGF-β1 titer tested by enzyme-linked immunosorbent assay, while the X-Ray Micro-CT/Micro Computed Tomography examined the volume’s development of the mandibular bone. Results: At the 7 days, 0.5 and 1% of α-mangostin had a better effect to increase the bone volume, and TGF-β1 titer has linearity of bone development at concentrations of 0.5 to 2%. At 14 days, 1 and 2% of α-mangostin exhibited a better effect on inducing an increase in mandibular bone volume and TGF-β1 titer. The linearity of both occurs at concentrations of 0.5 to 1%. The Micro-CT of the mandibular bone showed callus or new bone formation at the edge of each treatment group’s lesion as an indicator of bone remodeling. Conclusions: α-Mangostin induced an increase in the TGF-β1 titer, which was in line with the rise in the volume of the mandibular bone of Rattus novergicus.

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“…The use of Nanofillers in dentistry in the last years improved the mechanical properties of denture base materials [8]. For clinical use of denture bases, outstanding mechanical performance, as well as adequate biocompatibility and biosafety, are also needed, as some inorganic materials may irritate or even injure oral mucosa and gingival tissue [9,10]. It was claimed that hydroxyapatite nano-or micro powder has been successfully used as a biocompatible filler to reinforce the self-cured polymer matrix [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Nano and Micro Hydroxyapatite Particles on the Impact Strength of Acrylic Resin: In Vitro Study

Ahmed Abdulameer Abduljabbar,

Firas Abd kati,

Ayad I. Haddad

et al. 2023

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Poly (methylmethacrylate) is considered the basis material for a denture base. However, such substance has some drawbacks such as poor impact resistance, which is thought to be the primary cause of fracture of denture base resins. The purpose of the study was to determine how Nano and Micro hydroxyapatite particles affected the impact strength of acrylic resin. Thirty specimens were constructed of heat-cured acrylic resin and were divided into three groups: Ten specimens for the control, 10 for 1%nano hydroxyapatite, and 10 for micro hydroxyapatite. Acrylic samples were subjected to an impact strength test via a Charpy-type. Data were then analysed using SPSS v20. The ANOVA test was used for comparison among the groups. Highly statistically significant differences among all studied groups (P-value <0.0001). Both 5% Micro hydroxyapatite and 1% Nano hydroxyapatite had a higher mean value than the control. Incorporating Nano and Micro hydroxyapatite into PMMA improved the impact strength of acrylic resins.

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Nanotechnology in Dental Therapy and Oral Tissue Regeneration

Cited by 8 publications

References 331 publications

Evaluation of Antimicrobial and Antibiofilm Activities of Copper Oxide Nanoparticles within Soft Denture Liners against Oral Pathogens

Evaluation of Antimicrobial and Antibiofilm Activities of Copper Oxide Nanoparticles within Soft Denture Liners against Oral Pathogens

The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model

Evaluation of the Effect of Nano and Micro Hydroxyapatite Particles on the Impact Strength of Acrylic Resin: In Vitro Study

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