The α-mangostin effect on the quantity of TGF-β1 titer relate to the mandibular bone volume of Rattus novergicus in the periodontitis model

Abstract

Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones. The α-mangostin has shown role-playing in the bone remodeling process. Aims: To evaluate the potential of α-mangostin induce the TGFβ1 titer associated with the increased mandibular bone volume on the alveolar bone remodeling of periodontitis of Rattus novergicus. Methods: The α-mangostin used to the single administration dosage on the rat periodontitis model on the 7 and 14 days. TGF-β1 titer tested by enzyme-linked immunosorbent assay, while the X-Ray Micro-CT/Micro Computed Tomography examined the volume’s development of the mandibular bone. Results: At the 7 days, 0.5 and 1% of α-mangostin had a better effect to increase the bone volume, and TGF-β1 titer has linearity of bone development at concentrations of 0.5 to 2%. At 14 days, 1 and 2% of α-mangostin exhibited a better effect on inducing an increase in mandibular bone volume and TGF-β1 titer. The linearity of both occurs at concentrations of 0.5 to 1%. The Micro-CT of the mandibular bone showed callus or new bone formation at the edge of each treatment group’s lesion as an indicator of bone remodeling. Conclusions: α-Mangostin induced an increase in the TGF-β1 titer, which was in line with the rise in the volume of the mandibular bone of Rattus novergicus.

Mangosteen Peel Extract Increases Transforming Growth Factor-Beta in the Wound Healing Process

“…This is due to the presence of macrophages stimulated by flavonoids, resulting in the increased expression of TGF-β. 19 The increase in TGF-β following mangosteen peel extract treatment found in this study was also identified in a study examining the effect of alpha mangosteen on the quantity of TGF-β1 titter in periodontitis. In the study, alpha mangosteen hydrogel was applied to the entire area of the damaged and sutured Rattus norvegicus mandibular bone.…”

The EGCG and α-Mangosteen Stimulate SHED-IL10 and SHED-LL37 Metabolite Concentration

“…The finding showed that EGCG inhibits the process of alveolar bone damage through RANKL, 10 TNF-α, 11 and increases osteoprotegerin (OPG), 10 RANK, 10,11 and IL-10. 11,12 The effect is similar to α-mangosteen, which is able to stimulate some growth factors like tumor growth factor-β, 13 and TRAP5b 14 and also inhibit the growth of etiological bacteria 15,16 and RUNX2. 14 Periodontitis is a disease of the periodontal tissues that is characterized by damage to the ligaments and surrounding alveolar bone.…”