Nanotheranostics: A Possible Solution for Drug-Resistant Staphylococcus aureus and their Biofilms?

Mosselhy, Dina A.; Assad, Mhd Adel; Sironen, Tarja; Elbahri, Mady

doi:10.3390/nano11010082

Cited by 28 publications

(12 citation statements)

References 247 publications

(486 reference statements)

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“…219 In recent years, a field of nanomedicine called "nanotheranostics" has been developed for the diagnosis and treatment of diseases at the same time, and the development of bio-imaging probes is under intense investigation in this field. [220][221][222] The fluorescence imaging technology using quantum dots, which enables to visualize the behavior of individual cells in vivo and to treat them at the same time, has been attracting attention (Figure 2B). 223 Quantum dots, which are colloids of semiconducting nanoparticles approximately 2-50 nm in size, have fluorescent properties compared to fluorophores: negligible fluorescence photobleaching in response to the excitation light, a broader excitation spectrum, and a sharper emission peak.…”

Section: Silica Nanoparticlesmentioning

confidence: 99%

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Miyazawa¹,

Itaya²,

Burdeos³

et al. 2021

IJN

115

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Surfactants, whose existence has been recognized as early as 2800 BC, have had a long history with the development of human civilization. With the rapid development of nanotechnology in the latter half of the 20th century, breakthroughs in nanomedicine and food nanotechnology using nanoparticles have been remarkable, and new applications have been developed. The technology of surfactant-coated nanoparticles, which provides new functions to nanoparticles for use in the fields of nanomedicine and food nanotechnology, is attracting a lot of attention in the fields of basic research and industry. This review systematically describes these "surfactant-coated nanoparticles" through various sections in order: 1) surfactants, 2) surfactant-coated nanoparticles, application of surfactant-coated nanoparticles to 3) nanomedicine, and 4) food nanotechnology. Furthermore, current progress and problems of the technology using surfactant-coated nanoparticles through recent research reports have been discussed.

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Section: Silica Nanoparticlesmentioning

confidence: 99%

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

Miyazawa¹,

Itaya²,

Burdeos³

et al. 2021

IJN

115

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“…Drug resistance in biofilms is mostly associated with the slow growth of bacteria and the difficult diffusion of antibacterial agents. Therefore, tolerance will be lost in planktonic form with the dispersion of biofilms [7,8]. In biofilm organization, polysaccharide intercellular adhesin (PIA) is the major extracellular polysaccharide (EPS) encoded by the ica gene that participates in pathogenesis, including biofilm formation and immune evasion [9,10].…”

Section: Introductionmentioning

confidence: 99%

An Antisense yycF RNA Modulates Biofilm Organization of Methicillin-Resistant Staphylococcus aureus and Pathogenicity in a Rat Model of Osteomyelitis

Liu

Lei

et al. 2021

Antibiotics

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Staphylococcus aureus (S. aureus) is one of most common opportunistic pathogens and is attributed to several human infections. The increasing incidence of methicillin-resistant S. aureus (MRSA) is a serious clinical threat for osteomyelitis crisis. The YycFG two-component system of S. aureus regulates genes associated with biofilm formation. To investigate the potential role of an antisense yycF RNA in the regulation of transcription levels of yycF and associated effects on biofilm formation and pathogenicity, antisense yycF (ASyycF) RNA was detected by RT-PCR and 5′ RACE assays. ASyycF overexpression mutants were constructed, and the biofilm biomass was determined by crystal violet microtiter assay and scanning electron microscopy (SEM). Quantitative RT-PCR and Western blotting analyses were used to detect whether ASyycF overexpression inhibited the transcription and translation of biofilm-related genes. Then, a rat tibial infective model was used to evaluate the pathogenicity of ASyycF overexpression in vivo. ASyycF transcription led to reductions in YycF production and biofilm formation. Overexpression of ASyycF inhibited the transcription and translation of biofilm-related genes. The sensitivity to vancomycin was improved in ASyycF-overexpressing MRSA. Furthermore, ASyycF inhibited MRSA invasion in a rat tibial infection model. From this study, the expression of the YycF protein was found to be inversely correlated with different levels of ASyycF transcription. The biofilm biomass and pathogenicity decreased in the ASyycF-overexpressing mutant. Thus, the current evidence may support ASyycF as a supplementary strategy for managing S. aureus and MRSA infections.

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“…There is a consensus in the wound care community that among most wound infections, bacteria attach to wound surfaces and proliferate in the infected wound, delaying healing [ 12 ] and causing failure of treatment of wound infections [ 2 ]. Biofilms are intricate bacterial aggregates, producing an extracellular polymeric substance (EPS, a three-dimensional physical matrix formed of exopolysaccharides, lipids, proteins, and extracellular deoxyribonucleic acid, empowering bacteria with excessive resistance or tolerance against antibiotics) [ 13 ]. EPS encloses the cells, adheres to wounds, and prevents the penetration of antibiotics [ 9 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using an in vitro multispecies biofilm model

Zhang

Chen

et al. 2021

Regenerative Biomaterials

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Chronic wounds are a serious worldwide problem, which are often accompanied by wound infections. In this study, bacterial cellulose (BC)-based composites introduced with tannic acid (TA) and magnesium chloride (BC-TA-Mg) were fabricated for anti-biofilm activities. The prepared composites' surface properties, mechanical capacity, thermal stability, water absorption and retention property, releasing behavior, anti-biofilm activities, and potential cytotoxicity were tested. Results show that TA and MgCl2 particles closely adhered to the nanofibers of BC membranes, thus increasing surface roughness and hydrophobicity of the membranes. While the introduction of TA and MgCl2 did not influence the transparency of the membranes, making it beneficial for wound inspection. BC-TA and BC-TA-Mg composites displayed increased tensile strength and elongation at break compared to pure BC. Moreover, BC-TA-Mg exhibited higher water absorption and retention capacity than BC and BC-TA, suitable for the absorption of wound exudates. BC-TA-Mg demonstrated controlled release of TA and good inhibitory effect on both singly-cultured S. aureus and P. aeruginosa biofilm and co-cultured biofilm of S. aureus and P. aeruginosa. Furthermore, the cytotoxicity grade of BC-TA-6Mg membrane was eligible based on standard toxicity classifications. These indicated that BC-TA-Mg is potential to be used as wound dressings combating biofilms in chronic wounds.

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Nanotheranostics: A Possible Solution for Drug-Resistant Staphylococcus aureus and their Biofilms?

Cited by 28 publications

References 247 publications

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology

An Antisense yycF RNA Modulates Biofilm Organization of Methicillin-Resistant Staphylococcus aureus and Pathogenicity in a Rat Model of Osteomyelitis

Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using an in vitro multispecies biofilm model

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